Search Results - "Sumitra, Miriyala"

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration by Abdullah, Chowdhury S., Alam, Shafiul, Aishwarya, Richa, Miriyala, Sumitra, Bhuiyan, Mohammad Alfrad Nobel, Panchatcharam, Manikandan, Pattillo, Christopher B., Orr, A. Wayne, Sadoshima, Junichi, Hill, Joseph A., Bhuiyan, Md. Shenuarin

“…Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure…”
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Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer by Dong, Chenfang, Yuan, Tingting, Wu, Yadi, Wang, Yifan, Fan, Teresa W.M., Miriyala, Sumitra, Lin, Yiwei, Yao, Jun, Shi, Jian, Kang, Tiebang, Lorkiewicz, Pawel, St Clair, Daret, Hung, Mien-Chie, Evers, B. Mark, Zhou, Binhua P.

“…The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells with cancer stem cell (CSC)-like characteristics. We show that…”
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PPARγ and Its Role in Cardiovascular Diseases by Chandra, Mini, Panchatcharam, Manikandan, Miriyala, Sumitra

“…Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose…”
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Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species by Panchatcharam, Manikandan, Miriyala, Sumitra, Gayathri, Vinaya Subramani, Suguna, Lonchin

“…Wound healing consists of an orderly progression of events that re-establish the integrity of the damaged tissue. Several natural products have been shown to…”
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UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation by Sreedhar, Annapoorna, Petruska, Petra, Miriyala, Sumitra, Panchatcharam, Manikandan, Zhao, Yunfeng

“…Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane transporter which is often upregulated in human cancers. However, how this anion transporter…”
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Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes by Aishwarya, Richa, Alam, Shafiul, Abdullah, Chowdhury S., Morshed, Mahboob, Nitu, Sadia S., Panchatcharam, Manikandan, Miriyala, Sumitra, Kevil, Christopher G., Bhuiyan, Md. Shenuarin

“…Mitochondria are highly dynamic organelles that constantly undergo fission and fusion events to adapt to changes in the cellular environment. Aberrant…”
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The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia by Subedi, Utsab, Manikandan, Shrivats, Bhattarai, Susmita, Sharma, Papori, Sharma, Sudha, Sun, Hong, Miriyala, Sumitra, Panchatcharam, Manikandan

“…Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our group has recently shown that VSMC…”
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SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy by Sharma, Sudha, Bhattarai, Susmita, Ara, Hosne, Sun, Grace, St Clair, Daret K., Bhuiyan, Md Shenuarin, Kevil, Christopher, Watts, Megan N., Dominic, Paari, Shimizu, Takahiko, McCarthy, Kevin J., Sun, Hong, Panchatcharam, Manikandan, Miriyala, Sumitra

“…Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the…”
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Chronic Low-Dose Alcohol Consumption Attenuates Post-Ischemic Inflammation via PPARγ in Mice by Li, Chun, Li, Jiyu, Loreno, Ethyn G., Miriyala, Sumitra, Panchatcharam, Manikandan, Lu, Xiaohong, Sun, Hong

“…Ischemic stroke is one of the leading causes of death and permanent disability in adults. Recently, we found that light alcohol consumption (LAC) suppresses…”
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Protective Effect of Low-Dose Alcohol Consumption against Post-Ischemic Neuronal Apoptosis: Role of L-PGDS by Li, Chun, Li, Jiyu, Loreno, Ethyn G, Miriyala, Sumitra, Panchatcharam, Manikandan, Sun, Hong

“…Ischemic stroke is one of the leading causes of permanent disability and death in adults worldwide. Apoptosis is a major element contributing to post-ischemic…”
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Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure by Chandra, Mini, Escalante-Alcalde, Diana, Bhuiyan, Md. Shenuarin, Orr, Anthony Wayne, Kevil, Christopher, Morris, Andrew J., Nam, Hyung, Dominic, Paari, McCarthy, Kevin J., Miriyala, Sumitra, Panchatcharam, Manikandan

“…Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA)…”
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The ATX-LPA Axis Regulates Vascular Permeability during Cerebral Ischemic-Reperfusion by Bhattarai, Susmita, Sharma, Sudha, Subedi, Utsab, Ara, Hosne, Shum, Alika, Milena, Murov, Bhuiyan, Md Shenuarin, Kidambi, Srivatsan, Sun, Hong, Miriyala, Sumitra, Panchatcharam, Manikandan

“…Endothelial permeability is a major complication that must be addressed during stroke treatment. Study of the mechanisms underlying blood−brain barrier (BBB)…”
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Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics by Abdullah, Chowdhury S, Alam, Shafiul, Aishwarya, Richa, Miriyala, Sumitra, Panchatcharam, Manikandan, Bhuiyan, Mohammad Alfrad Nobel, Peretik, Jonette M, Orr, A Wayne, James, Jeanne, Osinska, Hanna, Robbins, Jeffrey, Lorenz, John N, Bhuiyan, Md Shenuarin

“…Background The Sigma 1 receptor (Sigmar1) functions as an interorganelle signaling molecule and elicits cytoprotective functions. The presence of Sigmar1 in…”
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Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke by Bhattarai, Susmita, Sharma, Sudha, Ara, Hosne, Subedi, Utsab, Sun, Grace, Li, Chun, Bhuiyan, Md Shenuarin, Kevil, Christopher, Armstrong, William P, Minvielle, Miles T, Miriyala, Sumitra, Panchatcharam, Manikandan

“…Background The loss of endothelial integrity increases the risk of intracerebral hemorrhage during ischemic stroke. Adjunct therapeutic targets for reperfusion…”
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Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux by Sharma, Sudha, Patel, Foram, Ara, Hosne, Bess, Ezra, Shum, Alika, Bhattarai, Susmita, Subedi, Utsab, Bell, Daquonte Sanard, Bhuiyan, Md Shenuarin, Sun, Hong, Batinic-Haberle, Ines, Panchatcharam, Manikandan, Miriyala, Sumitra

“…Reactive oxygen species (ROS) cause oxidative stress by generating reactive aldehydes known as 4-hydroxynonenal (4-HNE). 4-HNE modifies protein via covalent…”
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Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress by Sharma, Sudha, Sharma, Papori, Subedi, Utsab, Bhattarai, Susmita, Miller, Chloe, Manikandan, Shrivats, Batinic-Haberle, Ines, Spasojevic, Ivan, Sun, Hong, Panchatcharam, Manikandan, Miriyala, Sumitra

“…Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective…”
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Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction by Sharma, Sudha, Sharma, Papori, Bailey, Tara, Bhattarai, Susmita, Subedi, Utsab, Miller, Chloe, Ara, Hosne, Kidambi, Srivatsan, Sun, Hong, Panchatcharam, Manikandan, Miriyala, Sumitra

“…Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules with unpaired electrons. The excess of ROS leads to oxidative…”
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Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes by Alam, Shafiul, Abdullah, Chowdhury S, Aishwarya, Richa, Orr, A Wayne, Traylor, James, Miriyala, Sumitra, Panchatcharam, Manikandan, Pattillo, Christopher B, Bhuiyan, Md Shenuarin

“…C/EBP-homologous protein (CHOP) is a ubiquitously expressed stress-inducible transcription factor robustly induced by maladaptive endoplasmic reticulum (ER)…”
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Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-αB-Crystallin-Induced Desmin-Related Cardiomyopathy by Alam, Shafiul, Abdullah, Chowdhury S, Aishwarya, Richa, Morshed, Mahboob, Nitu, Sadia S, Miriyala, Sumitra, Panchatcharam, Manikandan, Kevil, Christopher G, Orr, A Wayne, Bhuiyan, Md Shenuarin

“…Background The mutated α-B-Crystallin (CryAB ) mouse model of desmin-related myopathy (DRM) shows an age-dependent onset of pathologic cardiac remodeling and…”
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Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells by Xiao, Adam Y, Maynard, Matthew R, Piett, Cortt G, Nagel, Zachary D, Alexander, J Steven, Kevil, Christopher G, Berridge, Michael V, Pattillo, Christopher B, Rosen, Lane R, Miriyala, Sumitra, Harrison, Lynn

“…Glioblastoma (GBM) has a poor prognosis despite intensive treatment with surgery and chemoradiotherapy. Previous studies using dose-escalated radiotherapy have…”
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