Search Results - "Sumii, Yuji"

Contribution of Organofluorine Compounds to Pharmaceuticals by Inoue, Munenori, Sumii, Yuji, Shibata, Norio

“…Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also…”
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Synthesis of Difluoromethanesulfinate Esters by the Difluoromethanesulfinylation of Alcohols by Sumii, Yuji, Sasaki, Kenta, Matsubara, Okiya, Shibata, Norio

“…Herein, we report the first synthesis of difluoromethanesulfinate esters via the direct difluoromethanesulfinylation of alcohols with HCF2SO2Na/Ph2P­(O)­Cl…”
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Synthesis of Chiral gem-Difluoromethylene Compounds by Enantioselective Ethoxycarbonyldifluoromethylation of MBH Fluorides via Silicon-Assisted C–F Bond Activation by Sumii, Yuji, Nagasaka, Takato, Wang, Jiandong, Uno, Hiroto, Shibata, Norio

“…The enantioselective ethoxycarbonyldifluoromethylation of Morita–Baylis–Hillman (MBH) fluorides with Me3SiCF2CO2Et under organocatalysis is described…”
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Regioselective Synthesis of Pyridine-SF4‑Methyl Ketones via Hydration of Pyridine-SF4‑Alkynes by Iwaki, Kentaro, Tanagawa, Kazuhiro, Mori, Soichiro, Maruno, Koki, Sumii, Yuji, Nagata, Osamu, Shibata, Norio

“…Herein, we report the metal-free hydration of pyridine-SF4-alkynes, under acidic conditions and with reaction durations ranging from 5 min to 10 h at room…”
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Anionic Triflyldiazomethane: Generation and Its Application for Synthesis of Pyrazole-3-triflones via [3 + 2] Cycloaddition Reaction by Das, Pulakesh, Gondo, Satoshi, Tokunaga, Etsuko, Sumii, Yuji, Shibata, Norio

“…The synthesis of pyrazole triflones containing a triflyl group at the 3-position is disclosed. Treatment of…”
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Synthesis of Pyridine–SF4–Isoxazolines Using the Functionality of trans-Tetrafluoro‑λ6‑sulfanyl Rodlike Linkers by Maruno, Koki, Hada, Kenshiro, Sumii, Yuji, Nagata, Osamu, Shibata, Norio

“…The tetrafluoro-λ6-sulfanyl (SF4) moiety has been relatively undeveloped since its discovery in the 1970s. In this study, we synthesized…”
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Studies of Halogen Bonding Induced by Pentafluorosulfanyl Aryl Iodides: A Potential Group of Halogen Bond Donors in a Rational Drug Design by Sumii, Yuji, Sasaki, Kenta, Tsuzuki, Seiji, Shibata, Norio

“…The activation of halogen bonding by the substitution of the pentafluoro-λ -sulfanyl (SF ) group was studied using a series of SF -substituted iodobenzenes…”
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Pentafluoroethylation of Carbonyl Compounds Using HFC-125 in a Flow Microreactor System by Ono, Makoto, Sumii, Yuji, Fujihira, Yamato, Kagawa, Takumi, Mimura, Hideyuki, Shibata, Norio

“…The protocol of micro-flow nucleophilic pentafluoroethylation using pentafluoroethane (HC2F5, HFC-125), a nontoxic, inexpensive, and commercially available…”
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Aryl gem-Difluorovinyl Pinacolboronates: Synthesis and Utility for Suzuki-Miyaura Coupling Reaction by Zhou, Jun, Jiang, Bingyao, Guo, Ming, Sumii, Yuji, Shibata, Norio

“…The synthesis of unstable aryl difluorovinyl pinacolboronates was achieved by the dehydrofluorination of α-trifluoromethyl arylmethyl pinacolboronates with…”
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Synthesis of Morita–Baylis–Hillman-fluorides using 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine by Sumii, Yuji, Nagasaka, Takato, Matsuno, Ayaka, Hayashi, Hidetoshi, Mimura, Hideyuki, Kagawa, Takumi, Shibata, Norio

“…Morita–Baylis–Hillman (MBH)-fluorides are valuable platforms for asymmetric allylic substitution reactions. However, the preparation of MBH-fluorides requires…”
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Continuous-Flow Synthesis of Perfluoroalkyl Ketones via Perfluoroalkylation of Esters Using HFC-23 and HFC-125 under a KHMDS–Triglyme System by Yamato Fujihira, Iwasaki, Hiroto, Sumii, Yuji, Adachi, Hiroaki, Kagawa, Takumi, Shibata, Norio

“…Hydrofluorocarbons (HFCs) are widely used as cooling agents in refrigerators and air conditioners and as solvents in industrial processes. However, their…”
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Synthesis of Pyridine-SF4-Alkynes via Light-Promoted Radical Coupling of Pyridine-SF4-Chlorides and EBX Reagents by Mahmoud, Elsayed M, Iwasaki, Hiroto, Hada, Kenshiro, Murata, Yusuke, Sumii, Yuji, Shibata, Norio

“…Pyridine-tetrafluoro-λ6-sulfanyl-alkynes have emerged as building blocks for synthesizing linearly-linked pyridine-heterocycles. They are prepared via a…”
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Unusual Photoisomerization Pathway in a Near-Infrared Light Absorbing Enzymerhodopsin by Sugiura, Masahiro, Ishikawa, Kazuki, Katayama, Kota, Sumii, Yuji, Abe-Yoshizumi, Rei, Tsunoda, Satoshi P., Furutani, Yuji, Shibata, Norio, Brown, Leonid S., Kandori, Hideki

“…Microbial and animal rhodopsins possess retinal chromophores which capture light and normally photoisomerize from all-trans to 13-cis and from 11-cis to…”
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Ortho-lithiation reaction of aryl triflones by Sumii, Yuji, Taniguchi, Misaki, Xu, Xiu-Hua, Tokunaga, Etsuko, Shibata, Norio

“…The ortho-lithiation of substituted arenes is a powerful methodology to synthesize ortho-substituted arenes. While a wide variety of directed metalation groups…”
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Study of the Structure-Activity Relationship of an Anti-Dormant Mycobacterial Substance 3-(Phenethylamino)Demethyl(oxy)aaptamine to Create a Probe Molecule for Detecting Its Target Protein by Sumii, Yuji, Kamiya, Kentaro, Nakamura, Takehiko, Tanaka, Kenta, Kaji, Takumi, Mukomura, Junya, Kotoku, Naoyuki, Arai, Masayoshi

“…The current tuberculosis treatment regimen is long and complex, and its failure leads to relapse and emergence of drug resistance. One of the major reasons…”
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Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments by Kawachi, Takashi, Tanaka, Shun, Fukuda, Akinori, Sumii, Yuji, Setiawan, Andi, Kotoku, Naoyuki, Kobayashi, Motomasa, Arai, Masayoshi

“…Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A ( ) and…”
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Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes by Sumii, Yuji, Sugita, Yutaka, Tokunaga, Etsuko, Shibata, Norio

“…The direct synthesis of aryl triflones, that is, trifluoromethanesulfonyl arenes, was achieved through the trifluoromethanesulfonylation of benzynes. The…”
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Stereoselective Synthesis of Core Structure of Cortistatin A by Kotoku, Naoyuki, Sumii, Yuji, Kobayashi, Motomasa

“…A stereoselective synthesis of the core structure of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian marine sponge, is described…”
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Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge by Sumii, Yuji, Kotoku, Naoyuki, Fukuda, Akinori, Kawachi, Takashi, Sumii, Yuta, Arai, Masayoshi, Kobayashi, Motomasa

“…[Display omitted] Total syntheses of (+)-dictyoceratin-C (1) and (+)-dictyoceratin-A (smenospondiol) (2), hypoxia-selective growth inhibitors isolated from…”
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Synthesis of Sulfur Perfluorophenyl Compounds Using a Pentafluorobenzenesulfonyl Hypervalent Iodonium Ylide by Wang, Jiandong, Jia, Shichong, Okuyama, Kenta, Huang, Zhongyan, Tokunaga, Etsuko, Sumii, Yuji, Shibata, Norio

“…A novel pentafluorobenzenesulfonyl hypervalent iodonium ylide 3 was designed and synthesized as a useful tool for the preparation of sulfur pentafluorophenyl…”
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