Search Results - "Sumigray, Kaelyn"

Morphogenesis and Compartmentalization of the Intestinal Crypt by Sumigray, Kaelyn D., Terwilliger, Michael, Lechler, Terry

“…The adult mammalian intestine is composed of two connected structures, the absorptive villi and the crypts, which house progenitor cells. Mouse crypts develop…”
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Cell Adhesion in Epidermal Development and Barrier Formation by Sumigray, Kaelyn D, Lechler, Terry

“…Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological…”
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The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine by Zhou, Kang, Sumigray, Kaelyn D, Lechler, Terry

“…The Arp2/3 complex is the only known nucleator of branched F-actin filaments. Work in cultured cells has established a wide array of functions for this complex…”
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Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment by Bonello, Teresa T, Perez-Vale, Kia Z, Sumigray, Kaelyn D, Peifer, Mark

“…Epithelial apical-basal polarity drives assembly and function of most animal tissues. Polarity initiation requires cell-cell adherens junction assembly at the…”
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Epigenetic control of intestinal barrier function and inflammation in zebrafish by Marjoram, Lindsay, Alvers, Ashley, Deerhake, M. Elizabeth, Bagwell, Jennifer, Mankiewicz, Jamie, Cocchiaro, Jordan L., Beerman, Rebecca W., Willer, Jason, Sumigray, Kaelyn D., Katsanis, Nicholas, Tobin, David M., Rawls, John F., Goll, Mary G., Bagnat, Michel

“…The intestinal epithelium forms a barrier protecting the organism from microbes and other proinflammatory stimuli. The integrity of this barrier and the proper…”
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Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut by Park, Jieun, Levic, Daniel S., Sumigray, Kaelyn D., Bagwell, Jennifer, Eroglu, Oznur, Block, Carina L., Eroglu, Cagla, Barry, Robert, Lickwar, Colin R., Rawls, John F., Watts, Stephen A., Lechler, Terry, Bagnat, Michel

“…The guts of neonatal mammals and stomachless fish have a limited capacity for luminal protein digestion, which allows oral acquisition of antibodies and…”
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Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium by Sumigray, Kaelyn D, Lechler, Terry

“…Maintaining proper cell-cell adhesion in the intestine is essential for tissue homeostasis and barrier function. This adhesion is thought to be mediated by…”
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Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo by Choi, Wangsun, Harris, Nathan J, Sumigray, Kaelyn D, Peifer, Mark

“…The establishment and maintenance of apical-basal cell polarity is critical for assembling epithelia and maintaining organ architecture. Drosophila embryos…”
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Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis by Sumigray, Kaelyn D, Chen, Hsin, Lechler, Terry

“…Desmosomes are cell-cell adhesion structures that integrate cytoskeletal networks. In addition to binding intermediate filaments, the desmosomal protein…”
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FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes by Foote, Henry P, Sumigray, Kaelyn D, Lechler, Terry

“…Proper development and tissue maintenance requires cell-cell adhesion structures, which serve diverse and crucial roles in tissue morphogenesis. Epithelial…”
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Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation by Sumigray, Kaelyn D, Foote, Henry P, Lechler, Terry

“…During differentiation, many cells reorganize their microtubule cytoskeleton into noncentrosomal arrays. Although these microtubules are likely organized to…”
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption by Sumigray, Kaelyn, Zhou, Kang, Lechler, Terry

“…Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in…”
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Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization by Huang, Xin, Nero, Thomas, Weerasekera, Ranjuna, Matej, Katherine H., Hinbest, Alex, Jiang, Zhaowei, Lee, Rebecca F., Wu, Longjun, Chak, Cecilia, Nijjer, Japinder, Gibaldi, Isabella, Yang, Hang, Gamble, Nathan, Ng, Wai-Leung, Malaker, Stacy A., Sumigray, Kaelyn, Olson, Rich, Yan, Jing

“…Bacterial biofilms are formed on environmental surfaces and host tissues, and facilitate host colonization and antibiotic resistance by human pathogens…”
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Cell Shape by Coercion: Par1 and aPKC Put the Squeeze on Junctions by Sumigray, Kaelyn D., Peifer, Mark

“…Epithelial sheets form the basic architectural unit of most tissues and organs. To form complex organs, these sheets are folded and reshaped by cell-shape…”
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CFTR High Expresser Cells in cystic fibrosis and intestinal diseases by Carlos dos Reis, Diego, Dastoor, Parinaz, Santos, Anderson Kenedy, Sumigray, Kaelyn, Ameen, Nadia A.

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl−/HCO3− channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many…”
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Spine Patterning Is Guided by Segmentation of the Notochord Sheath by Wopat, Susan, Bagwell, Jennifer, Sumigray, Kaelyn D., Dickson, Amy L., Huitema, Leonie F.A., Poss, Kenneth D., Schulte-Merker, Stefan, Bagnat, Michel

“…The spine is a segmented axial structure made of alternating vertebral bodies (centra) and intervertebral discs (IVDs) assembled around the notochord. Here, we…”
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Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis by Rogers, Edward M, Spracklen, Andrew J, Bilancia, Colleen G, Sumigray, Kaelyn D, Allred, S Colby, Nowotarski, Stephanie H, Schaefer, Kristina N, Ritchie, Benjamin J, Peifer, Mark

“…Abelson family kinases (Abls) are key regulators of cell behavior and the cytoskeleton during development and in leukemia. Abl's SH3, SH2, and tyrosine kinase…”
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Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID) by Ahsan, Md Kaimul, dos Reis, Diego Carlos, Barbieri, Andrea, Sumigray, Kaelyn D., Nottoli, Timothy, Salas, Pedro J., Ameen, Nadia A.

“…Microvillus inclusion disease (MVID), a lethal congenital diarrheal disease, results from loss of function mutations in the apical actin motor myosin VB…”
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Dissecting cell adhesion cross-talk with micropatterns by Sumigray, Kaelyn D, Lechler, Terry

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Redefining intestinal stemness: The emergence of a new ISC population by Li, Mei-Lan, Sumigray, Kaelyn

“…In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al…”
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