Search Results - "Sumida, Tomokazu S."

Hyperosmotic stress response regulates interstitial homeostasis and pathogenic inflammation by Sumida, Tomokazu S

“…Hyperosmotic stress triggers an evolutionally preserved, fundamental cellular response. A growing body of evidence has highlighted the role of extra-renal,…”
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Regulatory T cells in peripheral tissue tolerance and diseases by Cheru, Nardos, Hafler, David A, Sumida, Tomokazu S

“…Maintenance of peripheral tolerance by CD4 Foxp3 regulatory T cells (Tregs) is essential for regulating autoreactive T cells. The loss of function of Foxp3…”
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Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis by Asashima, Hiromitsu, Axisa, Pierre-Paul, Pham, Thi Hong Giang, Longbrake, Erin E, Ruff, William E, Lele, Nikhil, Cohen, Inessa, Raddassi, Khadir, Sumida, Tomokazu S, Hafler, David A

“…B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the…”
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Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure by Yamaguchi, Toshihiro, Sumida, Tomokazu S., Nomura, Seitaro, Satoh, Masahiro, Higo, Tomoaki, Ito, Masamichi, Ko, Toshiyuki, Fujita, Kanna, Sweet, Mary E., Sanbe, Atsushi, Yoshimi, Kenji, Manabe, Ichiro, Sasaoka, Toshikuni, Taylor, Matthew R. G., Toko, Haruhiro, Takimoto, Eiki, Naito, Atsuhiko T., Komuro, Issei

“…Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in…”
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NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data by He, Liang, Davila-Velderrain, Jose, Sumida, Tomokazu S., Hafler, David A., Kellis, Manolis, Kulminski, Alexander M.

“…The increasing availability of single-cell data revolutionizes the understanding of biological mechanisms at cellular resolution. For differential expression…”
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The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases by Sumida, Tomokazu S., Cheru, Nardos T., Hafler, David A.

“…The discovery of FOXP3 + regulatory T (T reg ) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper…”
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Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children by Ramaswamy, Anjali, Brodsky, Nina N., Sumida, Tomokazu S., Comi, Michela, Asashima, Hiromitsu, Hoehn, Kenneth B., Li, Ningshan, Liu, Yunqing, Shah, Aagam, Ravindra, Neal G., Bishai, Jason, Khan, Alamzeb, Lau, William, Sellers, Brian, Bansal, Neha, Guerrerio, Pamela, Unterman, Avraham, Habet, Victoria, Rice, Andrew J., Catanzaro, Jason, Chandnani, Harsha, Lopez, Merrick, Kaminski, Naftali, Dela Cruz, Charles S., Tsang, John S., Wang, Zuoheng, Yan, Xiting, Kleinstein, Steven H., van Dijk, David, Pierce, Richard W., Hafler, David A., Lucas, Carrie L.

“…Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious complication occurring unpredictably weeks after mild or…”
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Population genetics meets single-cell sequencing by Sumida, Tomokazu S, Hafler, David A

“…Single-cell technology can be used to understand the genetic basis of human diseases…”
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Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells by Sumida, Tomokazu S., Dulberg, Shai, Schupp, Jonas C., Lincoln, Matthew R., Stillwell, Helen A., Axisa, Pierre-Paul, Comi, Michela, Unterman, Avraham, Kaminski, Naftali, Madi, Asaf, Kuchroo, Vijay K., Hafler, David A.

“…Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not…”
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Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 by Unterman, Avraham, Sumida, Tomokazu S., Nouri, Nima, Yan, Xiting, Zhao, Amy Y., Gasque, Victor, Schupp, Jonas C., Asashima, Hiromitsu, Liu, Yunqing, Cosme, Carlos, Deng, Wenxuan, Chen, Ming, Raredon, Micha Sam Brickman, Hoehn, Kenneth B., Wang, Guilin, Wang, Zuoheng, DeIuliis, Giuseppe, Ravindra, Neal G., Li, Ningshan, Castaldi, Christopher, Wong, Patrick, Fournier, John, Bermejo, Santos, Sharma, Lokesh, Casanovas-Massana, Arnau, Vogels, Chantal B. F., Wyllie, Anne L., Grubaugh, Nathan D., Melillo, Anthony, Meng, Hailong, Stein, Yan, Minasyan, Maksym, Mohanty, Subhasis, Ruff, William E., Cohen, Inessa, Raddassi, Khadir, Niklason, Laura E., Ko, Albert I., Montgomery, Ruth R., Farhadian, Shelli F., Iwasaki, Akiko, Shaw, Albert C., van Dijk, David, Zhao, Hongyu, Kleinstein, Steven H., Hafler, David A., Kaminski, Naftali, Dela Cruz, Charles S.

“…Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology…”
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Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19 by Hoehn, Kenneth B, Ramanathan, Palaniappan, Unterman, Avraham, Sumida, Tomokazu S, Asashima, Hiromitsu, Hafler, David A, Kaminski, Naftali, Dela Cruz, Charles S, Sealfon, Stuart C, Bukreyev, Alexander, Kleinstein, Steven H

“…Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2-specific plasma cells and memory B cells postinfection or postvaccination…”
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A scalable approach to topic modelling in single-cell data by approximate pseudobulk projection by Subedi, Sishir, Sumida, Tomokazu S, Park, Yongjin P

“…Probabilistic topic modelling has become essential in many types of single-cell data analysis. Based on probabilistic topic assignments in each cell, we…”
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Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis by Unterman, Avraham, Zhao, Amy Y, Neumark, Nir, Schupp, Jonas C, Ahangari, Farida, Cosme, Jr, Carlos, Sharma, Prapti, Flint, Jasper, Stein, Yan, Ryu, Changwan, Ishikawa, Genta, Sumida, Tomokazu S, Gomez, Jose L, Herazo-Maya, Jose D, Dela Cruz, Charles S, Herzog, Erica L, Kaminski, Naftali

“…Changes in peripheral blood cell populations have been observed, but not detailed, at single-cell resolution in idiopathic pulmonary fibrosis (IPF). We sought…”
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Single Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis by Zhao, Amy Y, Unterman, Avraham, Abu Hussein, Nebal S., Sharma, Prapti, Nekola, Fadi, Flint, Jasper, Yan, Xiting, Adams, Taylor S, Justet, Aurelien, Sumida, Tomokazu S., Zhao, Jiayi, Schupp, Jonas C., Raredon, Micha Sam B., Ahangari, Farida, Deluliis, Giuseppe, Zhang, Yingze, Buendia-Roldan, Ivette, Adegunsoye, Ayodeji, Sperling, Anne I., Prasse, Antje, Ryu, Changwan, Herzog, Erica, Selman, Moises, Pardo, Annie, Kaminski, Naftali

“…Rationale: Fibrotic hypersensitivity pneumonitis (FHP) is a debilitating interstitial lung disease driven by incompletely understood immune mechanisms…”
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A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells by Axisa, Pierre-Paul, Yoshida, Tomomi M, Lucca, Liliana E, Kasler, Herbert G, Lincoln, Matthew R, Pham, Giang H, Del Priore, Dante, Carpier, Jean-Marie, Lucas, Carrie L, Verdin, Eric, Sumida, Tomokazu S, Hafler, David A

“…Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune diseases indicate that genes active in immune cells predominantly…”
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An autoimmune transcriptional circuit drives FOXP3 + regulatory T cell dysfunction by Sumida, Tomokazu S, Lincoln, Matthew R, He, Liang, Park, Yongjin, Ota, Mineto, Oguchi, Akiko, Son, Raku, Yi, Alice, Stillwell, Helen A, Leissa, Greta A, Fujio, Keishi, Murakawa, Yasuhiro, Kulminski, Alexander M, Epstein, Charles B, Bernstein, Bradley E, Kellis, Manolis, Hafler, David A

“…Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4 FOXP3 regulatory T cells…”
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PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection by Asashima, Hiromitsu, Mohanty, Subhasis, Comi, Michela, Ruff, William E., Hoehn, Kenneth B., Wong, Patrick, Klein, Jon, Lucas, Carolina, Cohen, Inessa, Coffey, Sarah, Lele, Nikhil, Greta, Leissa, Raddassi, Khadir, Chaudhary, Omkar, Unterman, Avraham, Emu, Brinda, Kleinstein, Steven H., Montgomery, Ruth R., Iwasaki, Akiko, Dela Cruz, Charles S., Kaminski, Naftali, Shaw, Albert C., Hafler, David A., Sumida, Tomokazu S.

“…T cell-B cell interaction is the key immune response to protect the host from severe viral infection. However, how T cells support B cells to exert protective…”
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Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis by Barmada, Anis, Klein, Jon, Ramaswamy, Anjali, Brodsky, Nina N, Jaycox, Jillian R, Sheikha, Hassan, Jones, Kate M, Habet, Victoria, Campbell, Melissa, Sumida, Tomokazu S, Kontorovich, Amy, Bogunovic, Dusan, Oliveira, Carlos R, Steele, Jeremy, Hall, E Kevin, Pena-Hernandez, Mario, Monteiro, Valter, Lucas, Carolina, Ring, Aaron M, Omer, Saad B, Iwasaki, Akiko, Yildirim, Inci, Lucas, Carrie L

“…Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular…”
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Cholesterol promotes IFNG mRNA expression in CD4 + effector/memory cells by SGK1 activation by Hanin, Aurélie, Comi, Michela, Sumida, Tomokazu S, Hafler, David A

“…IFNγ-secreting T cells are central for the maintenance of immune surveillance within the central nervous system (CNS). It was previously reported in healthy…”
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Distinct B cell repertoires characterize patients with mild and severe COVID-19 by Hoehn, Kenneth B., Ramanathan, Palaniappan, Unterman, Avraham, Sumida, Tomokazu S., Asashima, Hiromitsu, Hafler, David A., Kaminski, Naftali, Dela Cruz, Charles S., Sealfon, Stuart C., Bukreyev, Alexander, Kleinstein, Steven H.

“…Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2 specific plasma cells and memory B cells after infection or vaccination…”
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