Search Results - "Sumida, Tomoe"

Preparation of Aryne–Nickel Complexes from ortho-Borylaryl Triflates by Sumida, Yuto, Sumida, Tomoe, Hashizume, Daisuke, Hosoya, Takamitsu

“…A facile method for preparing diverse aryne–nickel complexes from readily synthesized ortho-borylaryl triflates is described. Exploratory synthetic…”
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Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborins by Sumida, Yuto, Harada, Ryu, Sumida, Tomoe, Johmoto, Kohei, Uekusa, Hidehiro, Hosoya, Takamitsu

“…An efficient transformation of dibenzoxaborins to dibenzofurans by deborylative ring contraction was achieved under mild conditions using a copper catalyst…”
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Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice by Nakano-Kobayashi, Akiko, Awaya, Tomonari, Kii, Isao, Sumida, Yuto, Okuno, Yukiko, Yoshida, Suguru, Sumida, Tomoe, Inoue, Haruhisa, Hosoya, Takamitsu, Hagiwara, Masatoshi

“…Down syndrome (DS) caused by trisomy of chromosome 21 is the most common genetic cause of intellectual disability. Although the prenatal diagnosis of DS has…”
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Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arenes by Sumida, Yuto, Harada, Ryu, Sumida, Tomoe, Hashizume, Daisuke, Hosoya, Takamitsu

“…The iridium-catalyzed direct C–H borylation of ring-fused (hetero)arenes afforded borylated products in a peri-selective manner, directed by a proximal…”
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Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A by Miyazaki, Yuka, Kikuchi, Masaki, Umezawa, Koji, Descamps, Aurelie, Nakamura, Daichi, Furuie, Gaku, Sumida, Tomoe, Saito, Kanako, Kimura, Ninako, Niwa, Takashi, Sumida, Yuto, Umehara, Takashi, Hosoya, Takamitsu, Kii, Isao

“…DYRK1A phosphorylates proteins involved in neurological disorders in an intermolecular manner. Meanwhile, during the protein folding process of DYRK1A, a…”
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Boron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M by Sumida, Yuto, Harada, Ryu, Kato-Sumida, Tomoe, Johmoto, Kohei, Uekusa, Hidehiro, Hosoya, Takamitsu

“…An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki–Miyaura cross-coupling between o-borylphenols and aryl halides or…”
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Selective inhibition of the kinase DYRK1A by targeting its folding process by Kii, Isao, Sumida, Yuto, Goto, Toshiyasu, Sonamoto, Rie, Okuno, Yukiko, Yoshida, Suguru, Kato-Sumida, Tomoe, Koike, Yuka, Abe, Minako, Nonaka, Yosuke, Ikura, Teikichi, Ito, Nobutoshi, Shibuya, Hiroshi, Hosoya, Takamitsu, Hagiwara, Masatoshi

“…Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has…”
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Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis by Masaki, So, Kii, Isao, Sumida, Yuto, Kato-Sumida, Tomoe, Ogawa, Yasushi, Ito, Nobutoshi, Nakamura, Mitsuhiro, Sonamoto, Rie, Kataoka, Naoyuki, Hosoya, Takamitsu, Hagiwara, Masatoshi

“…[Display omitted] Dysregulation of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) has been demonstrated in several pathological…”
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Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ by Sonamoto, Rie, Kii, Isao, Koike, Yuka, Sumida, Yuto, Kato-Sumida, Tomoe, Okuno, Yukiko, Hosoya, Takamitsu, Hagiwara, Masatoshi

“…The protein kinase family includes attractive targets for drug development. Methods for screening of kinase inhibitors remain largely limited to in vitro…”
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