Prognostic value of serum procalcitonin and C-reactive protein levels in critically ill patients who developed ventilator-associated pneumonia

Prognostic value of serum procalcitonin and C-reactive protein levels in critically ill patients who developed ventilator-associated pneumonia

Ventilator-associated pneumonia (VAP) is an important cause of mortality and morbidity in critically ill patients. We sought to determine the prognostic value of procalcitonin (PCT) and C-reactive protein (CRP) kinetics in critically ill patients who developed VAP. Patients who were admitted to the...

Full description

Saved in:
Bibliographic Details
Published in:Annals of thoracic medicine Vol. 10; no. 2; pp. 137 - 142
Main Authors: Tanrıverdi, Hakan, Tor, Müge Meltem, Kart, Levent, Altın, Remzi, Atalay, Figen, SumbSümbüloğlu, Vildan
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-04-2015
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Bacterial infections
Blood
C-reactive protein
Calcitonin
Confidence intervals
Hospitals
Intensive care
Intensive care unit
Medical prognosis
Mortality
Original
Patients
Physiological aspects
Physiology
Pneumonia
procalcitonin
Prognosis
Regression analysis
Sepsis
Staphylococcus infections
Ventilation
Viral infections
Saudi Arabia
procalcitonin
pneumonia
prognosis
Intensive care unit
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ventilator-associated pneumonia (VAP) is an important cause of mortality and morbidity in critically ill patients. We sought to determine the prognostic value of procalcitonin (PCT) and C-reactive protein (CRP) kinetics in critically ill patients who developed VAP. Patients who were admitted to the intensive care unit (ICU) and developed VAP were eligible. Patients were followed for 28 days after the pneumonia diagnosis and blood samples for PCT and CRP were collected on the day of the pneumonia diagnosis (D0), and days 3 (D3) and 7 (D7) after the diagnosis. Patients were grouped as survivors and non-survivors, and the mean PCT and CRP values and their kinetics were assessed. In total, 45 patients were enrolled. Of them, 22 (48.8%) died before day 28 after the pneumonia diagnosis. There was no significant difference between the survivor and non-survivor groups in terms of PCT on the day of pneumonia diagnosis or CRP levels at any point. However, the PCT levels days 3 and 7 were significantly higher in the non-survivor group than the survivor group. Whereas PCT levels decreased significantly from D0 to D7 in the survivor group, CRP did not. A PCT level above 1 ng/mL on day 3 was the strongest predictor of mortality, with an odds ratio of 22.6. Serum PCT was found to be a superior prognostic marker compared to CRP in terms of predicting mortality in critically ill patients who developed VAP. The PCT level on D3 was the strongest predictor of mortality in VAP.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1817-1737
1998-3557
DOI:10.4103/1817-1737.151442