Search Results - "Sumara, Izabela"

Feeding nuclear pores with condensed ME-AL-S by Sumara, Izabela

“…Izabela Sumara highlights the work by Beck and colleagues that identified a pathway for the biogenesis of nuclear pore complexes, which involves annulate…”
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The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications by Genschik, Pascal, Sumara, Izabela, Lechner, Esther

“…Protein ubiquitylation is a post‐translational modification that controls all aspects of eukaryotic cell functionality, and its defective regulation is…”
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Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease by Lin, Junyan, Sumara, Izabela

“…Nucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear…”
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Non-proteolytic ubiquitylation in cellular signaling and human disease by Liao, Yongrong, Sumara, Izabela, Pangou, Evanthia

“…Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation…”
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The Multifaceted Regulation of Mitochondrial Dynamics During Mitosis by Pangou, Evanthia, Sumara, Izabela

“…Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic material. Segregation of subcellular organelles during mitosis also…”
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Ubiquitin Binding Protein 2-Like (UBAP2L): is it so NICE After All? by Guerber, Lucile, Pangou, Evanthia, Sumara, Izabela

“…Ubiquitin Binding Protein 2-like (UBAP2L, also known as NICE-4) is a ubiquitin- and RNA-binding protein, highly conserved in metazoans. Despite its abundance,…”
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A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression by Pangou, Evanthia, Bielska, Olga, Guerber, Lucile, Schmucker, Stephane, Agote-Arán, Arantxa, Ye, Taozhi, Liao, Yongrong, Puig-Gamez, Marta, Grandgirard, Erwan, Kleiss, Charlotte, Liu, Yansheng, Compe, Emmanuel, Zhang, Zhirong, Aebersold, Ruedi, Ricci, Romeo, Sumara, Izabela

“…Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of…”
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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity by Stepniak, Ewa, Ricci, Romeo, Eferl, Robert, Sumara, Grzegorz, Sumara, Izabela, Rath, Martina, Hui, Lijian, Wagner, Erwin F

“…The AP-1 transcription factor c-Jun is a key regulator of hepatocyte proliferation. Mice lacking c-Jun in the liver (c-jun (Deltali*)) display impaired liver…”
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Fragile X-Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle-Dependent Manner by Agote-Arán, Arantxa, Lin, Junyan, Sumara, Izabela

“…Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the…”
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A Cul3-Based E3 Ligase Removes Aurora B from Mitotic Chromosomes, Regulating Mitotic Progression and Completion of Cytokinesis in Human Cells by Sumara, Izabela, Quadroni, Manfredo, Frei, Claudia, Olma, Michael H., Sumara, Grzegorz, Ricci, Romeo, Peter, Matthias

“…Faithful cell-cycle progression is tightly controlled by the ubiquitin-proteasome system. Here we identify a human Cullin 3-based E3 ligase (Cul3) which is…”
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Cul3-KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis by Maerki, Sarah, Olma, Michael H, Staubli, Titu, Steigemann, Patrick, Gerlich, Daniel W, Quadroni, Manfredo, Sumara, Izabela, Peter, Matthias

“…Cul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis. In this study, we identify two mammalian BTB…”
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The Dissociation of Cohesin from Chromosomes in Prophase Is Regulated by Polo-like Kinase by Sumara, Izabela, Vorlaufer, Elisabeth, Stukenberg, P.Todd, Kelm, Olaf, Redemann, Norbert, Nigg, Erich A., Peters, Jan-Michael

“…The separation of sister chromatids in anaphase depends on the dissociation of cohesin from chromosomes. In vertebrates, some cohesin is removed from…”
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Correction: Corrigendum: Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase by Courtheoux, Thibault, Enchev, Radoslav I., Lampert, Fabienne, Gerez, Juan, Beck, Jochen, Picotti, Paola, Sumara, Izabela, Peter, Matthias

“…Nature Communications 7: Article number: 12810 (2016); Published: 19 September 2016; Updated: 31 October 2016 References cited within the Supplementary Methods…”
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Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase by Courtheoux, Thibault, Enchev, Radoslav I., Lampert, Fabienne, Gerez, Juan, Beck, Jochen, Picotti, Paola, Sumara, Izabela, Peter, Matthias

“…Directed cell movement involves spatial and temporal regulation of the cortical microtubule (Mt) and actin networks to allow focal adhesions (FAs) to assemble…”
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human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes by Meyer-Schaller, Nathalie, Chou, Yang-Chieh, Sumara, Izabela, Martin, Dale D.O, Kurz, Thimo, Katheder, Nadja, Hofmann, Kay, Berthiaume, Luc G, Sicheri, Frank, Peter, Matthias

“…Cullin (Cul)-based E3 ubiquitin ligases are activated through the attachment of Nedd8 to the Cul protein. In yeast, Dcn1 (defective in Cul neddylation 1…”
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Regulation of Sister Chromatid Cohesion between Chromosome Arms by Giménez-Abián, Juan F, Sumara, Izabela, Hirota, Toru, Hauf, Silke, Gerlich, Daniel, de la Torre, Consuelo, Ellenberg, Jan, Peters, Jan-Michael

“…Sister chromatid separation in anaphase depends on the removal of cohesin complexes from chromosomes [1]. In vertebrates, the bulk of cohesin is already…”
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A Cul3-Based E3 Ligase Regulates Mitosis and is Required to Maintain the Spindle Assembly Checkpoint in Human Cells by Sumara, Izabela, Peter, Matthias

“…The spindle assembly checkpoint (SAC) is a mechanism that prevents premature chromosome segregation in anaphase before all chromosomes are correctly attached…”
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UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer by Krupina, Ksenia, Kleiss, Charlotte, Awal, Sushil, Rodriguez-Hernandez, Irene, Sanz-Moreno, Victoria, Sumara, Izabela

“…Defects in mitosis can lead to aneuploidy, which is a common feature of human cancers. Spindle Assembly Checkpoint (SAC) controls fidelity of chromosome…”
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Finding the midzone: the role of ubiquitination for CPC localization during anaphase by Maerki, Sarah, Sumara, Izabela

“…Commet on: Maerki S, et al. J Cell Biol. 2009; 187:791-800…”
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Cullin 3, a cellular scripter of the non-proteolytic ubiquitin code by Jerabkova, Katerina, Sumara, Izabela

“…Cullin-RING ubiquitin ligases (CRLs) represent the largest family of E3 ubiquitin ligases that control most if not all cellular processes. In CUL3-based CRLs,…”
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