Search Results - "Sumandea, C. Amelia"
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Funding Opportunities for Investigators in the Early Stages of Career Development
Published in Circulation (New York, N.Y.) (10-03-2009)“…Many sources of advice and guidance are available to the early career investigator. Generally, mentors serve as the primary source of information, although…”
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Augmented Phosphorylation of Cardiac Troponin I in Hypertensive Heart Failure
Published in The Journal of biological chemistry (06-01-2012)“…An altered cardiac myofilament response to activating Ca2+ is a hallmark of human heart failure. Phosphorylation of cardiac troponin I (cTnI) is critical in…”
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Cardiac Troponin T, a Sarcomeric AKAP, Tethers Protein Kinase A at the Myofilaments
Published in The Journal of biological chemistry (07-01-2011)“…Efficient and specific phosphorylation of PKA substrates, elicited in response to β-adrenergic stimulation, require spatially confined pools of PKA anchored in…”
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Impact of Cardiac Troponin T N-Terminal Deletion and Phosphorylation on Myofilament Function
Published in Biochemistry (Easton) (18-08-2009)“…Cardiac troponin T (cTnT) is a phosphoprotein that modulates cardiac muscle contraction through its extensive and diverse interactions with neighboring thin…”
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Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins
Published in Journal of molecular and cellular cardiology (01-05-2010)“…Abstract Ca2+ desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with…”
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Cardiomyopathy-Causing Deletion K210 in Cardiac Troponin T Alters Phosphorylation Propensity of Sarcomeric Proteins
Published in Biophysical journal (01-01-2010)Get full text
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Abstract 957: A Novel Interaction of Cardiac Troponin T with PKA Regulatory Subunits I and II
Published in Circulation (New York, N.Y.) (16-10-2007)“…Abstract only Increasing evidence suggests that cardiac myofilament activity is modulated by posttransla-tional modifications of cardiac troponin (cTn). In an…”
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