A prospective, randomized double-blind study in children comparing two doses of nebulized L-epinephrine in postintubation croup

To compare the effectiveness and side effects of nebulized l-epinephrine (NLE) at a dose of 0.05 mL/kg versus 0.5 mL/kg in the treatment of postintubation croup in children. Thirty-nine children, who developed signs and symptoms of upper airway obstruction (UAO) after extubation, were randomized to...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the Medical Association of Thailand Vol. 88; no. 4; p. 508
Main Authors:	Preutthipan, Aroonwan, Poomthavorn, Preamrudee, Sumanapisan, Apinya, Chinrat, Benchaporn, Thasuntia, Sriwanna, Plitponkarnpim, Adisak, Chantarojanasiri, Teerachai
Format:	Journal Article
Language:	English
Published:	Thailand 01-04-2005
Subjects:	Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Airway Obstruction - drug therapy Airway Obstruction - etiology Airway Obstruction - physiopathology Child Child, Preschool Croup - drug therapy Croup - etiology Drug Therapy, Combination Epinephrine - administration & dosage Epinephrine - therapeutic use Female Humans Infant Intensive Care Units, Pediatric Intubation, Intratracheal - adverse effects Male Nebulizers and Vaporizers Prospective Studies Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - therapeutic use
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To compare the effectiveness and side effects of nebulized l-epinephrine (NLE) at a dose of 0.05 mL/kg versus 0.5 mL/kg in the treatment of postintubation croup in children. Thirty-nine children, who developed signs and symptoms of upper airway obstruction (UAO) after extubation, were randomized to receive either 0.05 mL/kg or 0.5 mL/kg of NLE. UAO scores, vital signs (VS) and possible side effects were recorded before and at 20 and 40 minutes after the treatment. Twenty-one and 18 patients were allocated to the 0.05 and 0.5 mL/kg groups, respectively. Both groups showed improvements in UAO scores over time. There were no significant differences in UAO scores and VS between the groups at all time points. Side effects of epinephrine were not observed. In children with postintubation croup, the administration of NLE at the dose of 0.05 mL/kg results in similar improvements in the UAO scores, compared with the dose of 0.5 mL/kg. No complications were seen in either dose.
ISSN:	0125-2208