Search Results - "Sullivan, Jonathan T"

The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics by Norden, Diana M, Navia, Carmen T, Sullivan, Jonathan T, Doranz, Benjamin J

“…Specificity profiling is a requirement for monoclonal antibodies (mAbs) and antibody-directed biotherapeutics such as CAR-T cells prior to initiating human…”
Get full text

Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1 by McElvania Tekippe, Erin, Allen, Irving C, Hulseberg, Paul D, Sullivan, Jonathan T, McCann, Jessica R, Sandor, Matyas, Braunstein, Miriam, Ting, Jenny P-Y

“…The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role…”
Get full text

Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis by Allen, Irving C, McElvania-TeKippe, Erin, Wilson, Justin E, Lich, John D, Arthur, Janelle C, Sullivan, Jonathan T, Braunstein, Miriam, Ting, Jenny P Y

“…The majority of nucleotide binding domain leucine rich repeats-containing (NLR) family members has yet to be functionally characterized. Of the described NLRs,…”
Get full text

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth by Chukwuma, Valentine U, Kose, Nurgun, Sather, D Noah, Sapparapu, Gopal, Falk, Rachel, King, Hannah, Singh, Vidisha, Lampley, Rebecca, Malherbe, Delphine C, Ditto, Noah T, Sullivan, Jonathan T, Barnes, Trevor, Doranz, Benjamin J, Labranche, Celia C, Montefiori, David C, Kalams, Spyros A, Haigwood, Nancy L, Crowe, Jr, James E

“…Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs…”
Get full text

Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles by Tucker, David F., Sullivan, Jonathan T., Mattia, Kimberly-Anne, Fisher, Christine R., Barnes, Trevor, Mabila, Manu N., Wilf, Rona, Sulli, Chidananda, Pitts, Meghan, Payne, Riley J., Hall, Moniquetta, Huston-Paterson, Duncan, Deng, Xiaoxiang, Davidson, Edgar, Willis, Sharon H., Doranz, Benjamin J., Chambers, Ross, Rucker, Joseph B.

“…The insulin-responsive 12-transmembrane transporter GLUT4 changes conformation between an inward-open state and an outward-open state to actively facilitate…”
Get full text

Monoclonal Antibody 2C6 Targets a Cross-Clade Conformational Epitope in gp41 with Highly Active Antibody-Dependent Cell Cytotoxicity by Sojar, Hakimuddin, Baron, Sarah, Sullivan, Jonathan T, Garrett, Meghan, van Haaren, Marlies M, Hoffman, Jonathon, Overbaugh, Julie, Doranz, Benjamin J, Hicar, Mark D

“…Previous studies in our laboratory characterized a panel of highly mutated HIV-specific conformational epitope-targeting antibodies (Abs) from a panel of…”
Get full text

High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers by Sullivan, Jonathan T, Sulli, Chidananda, Nilo, Alberto, Yasmeen, Anila, Ozorowski, Gabriel, Sanders, Rogier W, Ward, Andrew B, Klasse, P J, Moore, John P, Doranz, Benjamin J

“…Soluble envelope glycoprotein (Env) trimers (SOSIP.664 gp140) are attractive HIV-1 vaccine candidates, with structures that mimic the native membrane-bound Env…”
Get full text

Correction: Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis by Allen, Irving C., McElvania-TeKippe, Erin, Wilson, Justin E., Lich, John D., Arthur, Janelle C., Sullivan, Jonathan T., Braunstein, Miriam, Ting, Jenny P. Y.

“…Please download the article again to view the correct figures. (2013) Correction: Characterization of NLRP12 during the In Vivo Host Immune Response to…”
Get full text

Abstract 5798: Preclinical safety assessment for specificity of biotherapeutics using the membrane proteome array by Raghavan, Kristopher S., Sullivan, Jonathan T., Navia, Carmen, Fong, Rachel H., Doranz, Benjamin J.

“…Abstract Rigorous specificity analysis is critical for the development of antibody-based therapies, as even minimal off-target binding can lead to toxicity and…”
Get full text

Abstract 6743: Identifying new cellular adjuvants for cancer vaccines and immunotherapies by Rucker, Joseph, Nwogu, Nnenna, Molino, Nicholas M., Snyder, Ami, Sullivan, Jonathan T., Doranz, Benjamin J.

“…Abstract Background: Cancer vaccines represent a promising strategy for antitumor immunotherapy. Despite considerable research efforts and progress, the…”
Get full text

Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis. e60842 by Allen, Irving C, McElvania-TeKippe, Erin, Wilson, Justin E, Lich, John D, Arthur, Janelle C, Sullivan, Jonathan T, Braunstein, Miriam, Ting, Jenny PY

“…The majority of nucleotide binding domain leucine rich repeats-containing (NLR) family members has yet to be functionally characterized. Of the described NLRs,…”
Get full text

Correction: Characterization of NLRP12 during the Host Immune Response to and by Irving C. Allen, Erin McElvania-TeKippe, Justin E. Wilson, John D. Lich, Janelle C. Arthur, Jonathan T. Sullivan, Miriam Braunstein, Jenny P. Y. Ting

Get full text