Search Results - "Sullivan, Jeremy M."

TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease by Kwon, Do Hoon, Zhang, Feng, McCray, Brett A., Feng, Shasha, Kumar, Meha, Sullivan, Jeremy M., Im, Wonpil, Sumner, Charlotte J., Lee, Seok-Yong

“…Crosstalk between ion channels and small GTPases is critical during homeostasis and disease, but little is known about the structural underpinnings of these…”
Get full text

Editorial: Sensory systems of aquatic animals by Sullivan, Jeremy M, Bonnaud-Ponticelli, Laure, Di Cosmo, Anna

Get full text

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2 by Woolums, Brian M., McCray, Brett A., Sung, Hyun, Tabuchi, Masashi, Sullivan, Jeremy M., Ruppell, Kendra Takle, Yang, Yunpeng, Mamah, Catherine, Aisenberg, William H., Saavedra-Rivera, Pamela C., Larin, Bryan S., Lau, Alexander R., Robinson, Douglas N., Xiang, Yang, Wu, Mark N., Sumner, Charlotte J., Lloyd, Thomas E.

“…The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited…”
Get full text

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension by McCray, Brett A., Diehl, Erika, Sullivan, Jeremy M., Aisenberg, William H., Zaccor, Nicholas W., Lau, Alexander R., Rich, Dominick J., Goretzki, Benedikt, Hellmich, Ute A., Lloyd, Thomas E., Sumner, Charlotte J.

“…TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense…”
Get full text

A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission by Wong, Ching-On, Chen, Kuchuan, Lin, Yong Qi, Chao, Yufang, Duraine, Lita, Lu, Zhongmin, Yoon, Wan Hee, Sullivan, Jeremy M., Broadhead, Geoffrey T., Sumner, Charlotte J., Lloyd, Thomas E., Macleod, Gregory T., Bellen, Hugo J., Venkatachalam, Kartik

“…Presynaptic resting Ca2+ influences synaptic vesicle (SV) release probability. Here, we report that a TRPV channel, Inactive (Iav), maintains presynaptic…”
Get full text

Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy by Sullivan, Jeremy M, Motley, William W, Johnson, Janel O, Aisenberg, William H, Marshall, Katherine L, Barwick, Katy Es, Kong, Lingling, Huh, Jennifer S, Saavedra-Rivera, Pamela C, McEntagart, Meriel M, Marion, Marie-Helene, Hicklin, Lucy A, Modarres, Hamid, Baple, Emma L, Farah, Mohamed H, Zuberi, Aamir R, Lutz, Cathleen M, Gaudet, Rachelle, Traynor, Bryan J, Crosby, Andrew H, Sumner, Charlotte J

“…Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis…”
Get full text

Stem and progenitor cell compartments within adult mouse taste buds by Sullivan, Jeremy M., Borecki, Alexander A., Oleskevich, Sharon

“…Adult taste buds are maintained by the lifelong proliferation of epithelial stem and progenitor cells, the identities of which have remained elusive. It has…”
Get full text

Adult neurogenesis: A common strategy across diverse species by Sullivan, Jeremy M., Benton, Jeanne L., Sandeman, David C., Beltz, Barbara S.

“…Adult neurogenesis, the generation of new neurons from adult precursor cells, occurs in the brains of a phylogenetically diverse array of animals. In the…”
Get full text

Integration and segregation of inputs to higher-order neuropils of the crayfish brain by Sullivan, Jeremy M., Beltz, Barbara S.

“…Information about the input and output pathways of higher‐order brain neuropils is essential for gaining an understanding of their functions. The present study…”
Get full text

Automated threshold detection for auditory brainstem responses: comparison with visual estimation in a stem cell transplantation study by Bogaerts, Sofie, Clements, John D, Sullivan, Jeremy M, Oleskevich, Sharon

“…Auditory brainstem responses (ABRs) are used to study auditory acuity in animal-based medical research. ABRs are evoked by acoustic stimuli, and consist of an…”
Get full text

Effect of epithelial stem cell transplantation on noise-induced hearing loss in adult mice by Sullivan, Jeremy M, Cohen, Mauricio A, Pandit, Sonali R, Sahota, Raguwinder S, Borecki, Alexander A, Oleskevich, Sharon

“…Abstract Noise trauma in mammals can result in damage to multiple epithelial cochlear cell types, producing permanent hearing loss. Here we investigate whether…”
Get full text

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization by Aisenberg, William H., McCray, Brett A., Sullivan, Jeremy M., Diehl, Erika, DeVine, Lauren R., Alevy, Jonathan, Bagnell, Anna M., Carr, Patrice, Donohue, Jack K., Goretzki, Benedikt, Cole, Robert N., Hellmich, Ute A., Sumner, Charlotte J.

“…Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation of endocytosis. Whether ubiquitination can modulate…”
Get full text

Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice by Sullivan, Jeremy M, Bagnell, Anna M, Alevy, Jonathan, Avila, Elvia Mena, Mihaljević, Ljubica, Saavedra-Rivera, Pamela C, Kong, Lingling, Huh, Jennifer S, McCray, Brett A, Aisenberg, William H, Zuberi, Aamir R, Bogdanik, Laurent, Lutz, Cathleen M, Qiu, Zhaozhu, Quinlan, Katharina A, Searson, Peter C, Sumner, Charlotte J

“…Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether barrier breakdown is sufficient to trigger neurodegenerative disease…”
Get more information

Exploring P2X7 receptor antagonism as a therapeutic target for neuroprotection in an hiPSC motor neuron model by Johns, Alexandra E, Taga, Arens, Charalampopoulou, Andriana, Gross, Sarah K, Rust, Khalil, McCray, Brett A, Sullivan, Jeremy M, Maragakis, Nicholas J

“…ATP is present in negligible concentrations in the interstitium of healthy tissues but accumulates to significantly higher concentrations in an inflammatory…”
Get full text

TRPV4 Antagonism Prevents Mechanically Induced Myotonia by Dupont, Chris, Novak, Kevin, Denman, Kirsten, Myers, Jessica H., Sullivan, Jeremy M., Walker, Phillip V., Brown, Nicklaus L., Ladle, David R., Bogdanik, Laurent, Lutz, Cathleen M., Voss, Andrew, Sumner, Charlotte J., Rich, Mark M.

“…Objective Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are…”
Get full text

Functional Effects of Adult Human Olfactory Stem Cells on Early‐Onset Sensorineural Hearing Loss by Pandit, Sonali R., Sullivan, Jeremy M., Egger, Viktoria, Borecki, Alexander A., Oleskevich, Sharon

“…Transplantation of exogenous stem cells has been proposed as a treatment to prevent or reverse sensorineural hearing loss. Here, we investigate the effects of…”
Get full text

Transient Uptake of Serotonin by Newborn Olfactory Projection Neurons by Beltz, Barbara S., Benton, Jeanne L., Sullivan, Jeremy M.

“…A life-long turnover of sensory and interneuronal populations has been documented in the olfactory pathways of both vertebrates and invertebrates, creating a…”
Get full text

Phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathy by Sullivan, Jeremy M, Landouré, Guida, Gaudet, Rachelle, Sumner, Charlotte J

“…Echaniz-Laguna et al.[1] investigated TRPV4 mutations in inherited neuropathy and presented excellent clinical descriptions. However, we have some concerns…”
Get full text

EXOME SEQUENCING IDENTIFIES A NOVEL TRPV4 MUTATION IN A CMT2C FAMILY by LANDOURE, Guida, SULLIVAN, Jeremy M, TRAYNOR, Bryan J, BURNETT, Barrington G, SUMNER, Charlotte J, JOHNSON, Janel O, MUNNS, Clare H, YIJUN SHI, DIALLO, Oumarou, RAPHAEL GIBBS, J, GAUDET, Rachelle, LUDLOW, Christy L, FISCHBECK, Kenneth H

Get full text

Brain photoreceptor pathways contributing to circadian rhythmicity in crayfish by Sullivan, Jeremy M, Genco, Maria C, Marlow, Elizabeth D, Benton, Jeanne L, Beltz, Barbara S, Sandeman, David C

“…Freshwater crayfish have three known photoreceptive systems: the compound eyes, extraretinal brain photoreceptors, and caudal photoreceptors. The primary goal…”
Get more information