Search Results - "Sullivan, Jack M."

Phylogeography, genetic diversity, and connectivity of brown bear populations in Central Asia by Tumendemberel, Odbayar, Zedrosser, Andreas, Proctor, Michael F, Reynolds, Harry V, Adams, Jennifer R, Sullivan, Jack M, Jacobs, Sarah J, Khorloojav, Tumennasan, Tserenbataa, Tuya, Batmunkh, Mijiddorj, Swenson, Jon E, Waits, Lisette P

“…Knowledge of genetic diversity and population structure is critical for conservation and management planning at the population level within a species' range…”
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Fine-Scale Adaptations to Environmental Variation and Growth Strategies Drive Phyllosphere Methylobacterium Diversity by Leducq, Jean-Baptiste, Seyer-Lamontagne, Émilie, Condrain-Morel, Domitille, Bourret, Geneviève, Sneddon, David, Foster, James A, Marx, Christopher J, Sullivan, Jack M, Shapiro, B Jesse, Kembel, Steven W

“…is a prevalent bacterial genus of the phyllosphere. Despite its ubiquity, little is known about the extent to which its diversity reflects neutral processes…”
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Pharmacokinetics of Monoclonal Antibody and Antibody Fragments in The Mouse Eye Following Intravitreal Administration by Bussing, David, Li, Yingyi, Guo, Leiming, Verma, Ashwni, Sullivan, Jack M, Shah, Dhaval K

“…Mice are rarely used in pharmacokinetic (PK) studies of ocular therapeutics due to the small size of their eyes and challenges in drug administration, tissue…”
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No evidence for phylosymbiosis in western chipmunk species by Grond, Kirsten, Bell, Kayce C, Demboski, John R, Santos, Malia, Sullivan, Jack M, Hird, Sarah M

“…ABSTRACT Phylosymbiosis refers to a congruent pattern between the similarity of microbiomes of different species and the branching pattern of the host…”
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Fundus autofluorescence and photoreceptor cell rosettes in mouse models by Flynn, Erin, Ueda, Keiko, Auran, Emily, Sullivan, Jack M, Sparrow, Janet R

“…This study was conducted to study correlations among fundus autofluorescence (AF), RPE lipofuscin accumulation, and photoreceptor cell degeneration and to…”
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RTN4IP1 -associated non-syndromic optic neuropathy and rod-cone dystrophy by Gupta, Priya R, O'Connell, Kaitlin, Sullivan, Jack M, Huckfeldt, Rachel M

“…Biallelic variants in RTN4IP1 are a well-established cause of syndromic and nonsyndromic early-onset autosomal recessive optic neuropathy. They have more…”
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A Novel, Real-Time, In Vivo Mouse Retinal Imaging System by Butler, Mark C, Sullivan, Jack M

“…To develop an efficient, low-cost instrument for robust real-time imaging of the mouse retina in vivo, and assess system capabilities by evaluating various…”
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Effects of Pathogenic Variations in the Human Rhodopsin Gene (hRHO) on the Predicted Accessibility for a Lead Candidate Ribozyme by Froebel, Beau R, Trujillo, Alexandria J, Sullivan, Jack M

“…The mutation-independent strategy for hammerhead ribozyme (hhRz) or RNA interference (RNAi)-based gene therapeutics to treat autosomal dominant diseases is…”
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Glaucoma Genetic Risk Scores in the Million Veteran Program by Waksmunski, Andrea R., Kinzy, Tyler G., Cruz, Lauren A., Nealon, Cari L., Halladay, Christopher W., Simpson, Piana, Canania, Rachael L., Anthony, Scott A., Roncone, David P., Sawicki Rogers, Lea, Leber, Jenna N., Dougherty, Jacquelyn M., Greenberg, Paul B., Sullivan, Jack M., Wu, Wen-Chih, Iyengar, Sudha K., Crawford, Dana C., Peachey, Neal S., Gaziano, J. Michael, Breeling, Jim, Chang, Kyong-Mi, Huang, Grant, Muralidhar, Sumitra, O’Donnell, Christopher J., Tsao, Philip S., Moser, Jennifer, Whitbourne, Stacey B., Brewer, Jessica V., Concato, John, Warren, Stuart, Argyres, Dean P., Stephens, Brady, Brophy, Mary T., Humphries, Donald E., Do, Nhan, Shayan, Shahpoor, Nguyen, Xuan-Mai T., Pyarajan, Saiju, Cho, Kelly, Hauser, Elizabeth, Sun, Yan, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Harley, John, Whittle, Jeffrey, Beckham, Jean, Wells, John, Gutierrez, Salvador, Gibson, Gretchen, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Haddock, Kathlyn Sue, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Buford, Malcolm, Mastorides, Stephen, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Swann, Alan, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Washburn, Ronald, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Gutierrez, Amparo, Schifman, Ronald, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Oehlert, Mary, Wallbom, Agnes, Fernando, Ronald, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Tsao, Philip, Sonel, Elif, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Fayad, Joseph, Hung, Adriana, Lichy, Jack, Hurley, Robin, Robey, Brooks, Striker, Robert

“…Primary open-angle glaucoma (POAG) is a degenerative eye disease for which early treatment is critical to mitigate visual impairment and irreversible…”
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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research by Butler, Mark C, Sullivan, Jack M

“…HR-SD-OCT is utilized to monitor the progression of photoreceptor degeneration in live mouse models, assess the delivery of therapeutic agents into the…”
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A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets by Yau, Edwin H., Butler, Mark C., Sullivan, Jack M.

“…Major bottlenecks in development of therapeutic post transcriptional gene silencing (PTGS) agents (e.g. ribozymes, RNA interference, antisense) include the…”
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Comprehensive Phylogenomics of Methylobacterium Reveals Four Evolutionary Distinct Groups and Underappreciated Phyllosphere Diversity by Leducq, Jean-Baptiste, Sneddon, David, Santos, Malia, Condrain-Morel, Domitille, Bourret, Geneviève, Martinez-Gomez, N Cecilia, Lee, Jessica A, Foster, James A, Stolyar, Sergey, Shapiro, B Jesse, Kembel, Steven W, Sullivan, Jack M, Marx, Christopher J

“…Abstract Methylobacterium is a group of methylotrophic microbes associated with soil, fresh water, and particularly the phyllosphere, the aerial part of plants…”
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A Discovery with Potential to Revitalize Hammerhead Ribozyme Therapeutics for Treatment of Inherited Retinal Degenerations by Trujillo, Alexandria J, Myers, Jason M, Fayazi, Zahra S, Butler, Mark C, Sullivan, Jack M

“…Hammerhead ribozymes (hhRzs), RNA enzymes capable of site-specific cleavage of arbitrary target mRNAs, have faced significant hurdles in development and…”
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Focus on Molecules: ABCA4 (ABCR) – An import-directed photoreceptor retinoid flipase by Sullivan, Jack M.

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Association Between Fuchs Endothelial Corneal Dystrophy, Diabetes Mellitus, and Multimorbidity by Nealon, Cari L., Halladay, Christopher W., Gorman, Bryan R., Simpson, Piana, Roncone, David P., Canania, Rachael L., Anthony, Scott A., Sawicki Rogers, Lea R., Leber, Jenna N., Dougherty, Jacquelyn M., Cooke Bailey, Jessica N., Crawford, Dana C., Sullivan, Jack M., Galor, Anat, Wu, Wen-Chih, Greenberg, Paul B., Lass, Jonathan H., Iyengar, Sudha K., Peachey, Neal S.

“…The aim of this study was to assess risk for demographic variables and other health conditions that are associated with Fuchs endothelial corneal dystrophy…”
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HEK293S cells have functional retinoid processing machinery by Brueggemann, Lioubov I, Sullivan, Jack M

“…Rhodopsin activation is measured by the early receptor current (ERC), a conformation-associated charge motion, in human embryonic kidney cells (HEK293S)…”
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Development and Evaluation of a Rules-based Algorithm for Primary Open-Angle Glaucoma in the VA Million Veteran Program by Nealon, Cari L., Halladay, Christopher W., Kinzy, Tyler G., Simpson, Piana, Canania, Rachael L., Anthony, Scott A., Roncone, David P., Sawicki Rogers, Lea R., Leber, Jenna N., Dougherty, Jacquelyn M., Sullivan, Jack M., Wu, Wen-Chih, Greenberg, Paul B., Iyengar, Sudha K., Crawford, Dana C., Peachey, Neal S., Cooke Bailey, Jessica N.

“…The availability of electronic health record (EHR)-linked biobank data for research presents opportunities to better understand complex ocular diseases…”
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Variables and Strategies in Development of Therapeutic Post-Transcriptional Gene Silencing Agents by Sullivan, Jack M., Yau, Edwin H., Kolniak, Tiffany A., Sheflin, Lowell G., Taggart, R. Thomas, Abdelmaksoud, Heba E.

“…Post-transcriptional gene silencing (PTGS) agents such as ribozymes, RNAi and antisense have substantial potential for gene therapy of human retinal…”
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Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program by Waksmunski, Andrea R, Kinzy, Tyler G, Cruz, Lauren A, Nealon, Cari L, Halladay, Christopher W, Anthony, Scott A, Greenberg, Paul B, Sullivan, Jack M, Wu, Wen-Chih, Iyengar, Sudha K, Crawford, Dana C, Peachey, Neal S, Cooke Bailey, Jessica N

“…A major goal of precision medicine is to stratify patients based on their genetic risk for a disease to inform future screening and intervention strategies…”
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Rapid, cell-based toxicity screen of potentially therapeutic post-transcriptional gene silencing agents by Kolniak, Tiffany A., Sullivan, Jack M.

“…Post-transcriptional gene silencing (PTGS) agents such as antisense, ribozymes and RNA interference (RNAi) have great potential as therapeutics for a variety…”
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