Search Results - "Sullivan, David J."

Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sources by Sullivan, David J., Franchini, Massimo, Joyner, Michael J., Casadevall, Arturo, Focosi, Daniele

“…The latest SARS-CoV-2 variant of concern Omicron, with its immune escape from therapeutic anti-Spike monoclonal antibodies and WA-1 vaccine-elicited sera,…”
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Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma by Zhou, Jiangbing, Patel, Toral R., Sirianni, Rachael W., Strohbehn, Garth, Zheng, Ming-Qiang, Duong, Nha, Schafbauer, Thomas, Huttner, Anita J., Huang, Yiyun, Carson, Richard E., Zhang, Ying, Sullivan, David J., Piepmeier, Joseph M., Saltzman, W. Mark

“…Current therapy for glioblastoma multiforme is insufficient, with nearly universal recurrence. Available drug therapies are unsuccessful because they fail to…”
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Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in Plasmodium falciparum Culture by West, Rachel, Sullivan, David J

“…Malaria infection by continues to afflict millions of people worldwide, with transmission being dependent upon mosquito ingestion of the parasite gametocyte…”
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Quinolines block every step of malaria heme crystal growth by Sullivan, David J.

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restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells by Avril, Marion, Tripathi, Abhai K, Brazier, Andrew J, Andisi, Cheryl, Janes, Joel H, Soma, Vijaya L, Sullivan, David J, Bull, Peter C, Stins, Monique F, Smith, Joseph D

“…Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but specific interactions involved in cerebral homing of infected…”
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Antiviral combination therapies for persistent COVID-19 in immunocompromised patients by Focosi, Daniele, Maggi, Fabrizio, D'Abramo, Alessandra, Nicastri, Emanuele, Sullivan, David J

“…•Immunocompromised patients require combined antiviral therapies.•In vitro synergies exist for small molecule antivirals and passive…”
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New uses for old drugs by Chong, Curtis R, Sullivan, David J

“…The current costly and time-consuming paradigm of drug discovery is ill-equipped to combat rapidly emerging diseases, such as avian flu, drug-resistant…”
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Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria by Lukianova-Hleb, Ekaterina Y., Campbell, Kelly M., Constantinou, Pamela E., Braam, Janet, Olson, John S., Ware, Russell E., Sullivan, David J., Lapotko, Dmitri O.

“…Successful diagnosis, screening, and elimination of malaria critically depend on rapid and sensitive detection of this dangerous infection, preferably…”
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Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression by Poropatich, Kate, Sullivan, Jr, David J

“…A small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive individuals--referred to as long-term non-progressors (LTNPs)--maintain a…”
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The Potential Role of Passive Antibody-Based Therapies as Treatments for Monkeypox by Bloch, Evan M, Sullivan, David J, Shoham, Shmuel, Tobian, Aaron A R, Casadevall, Arturo, Gebo, Kelly A

“…Monkeypox, a zoonosis caused by the orthopox monkeypox virus (MPXV) that is endemic to Central and West Africa, was previously linked to sporadic outbreaks and…”
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Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito by Balta, Victoria A., Stiffler, Deborah, Sayeed, Abeer, Tripathi, Abhai K., Elahi, Rubayet, Mlambo, Godfree, Bakshi, Rahul P., Dziedzic, Amanda G., Jedlicka, Anne E., Nenortas, Elizabeth, Romero-Rodriguez, Keyla, Canonizado, Matthew A., Mann, Alexis, Owen, Andrew, Sullivan, David J., Prigge, Sean T., Sinnis, Photini, Shapiro, Theresa A.

“…Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine…”
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Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity by Sanders, Natalie G, Sullivan, David J, Mlambo, Godfree, Dimopoulos, George, Tripathi, Abhai K

“…Discovery of transmission blocking compounds is an important intervention strategy necessary to eliminate and eradicate malaria. To date only a small number of…”
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Plasmodium drug targets outside the genetic control of the parasite by Sullivan, David J

“…Drug development often seeks to find "magic bullets" which target microbiologic proteins while not affecting host proteins. Paul Ehrlich tested methylene blue…”
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Applying lessons of COVID-19 and other emerging infectious diseases to future outbreaks by Bloch, Evan M, Sullivan, David J, Casadevall, Arturo, Shoham, Shmuel, Tobian, Aaron A R, Gebo, Kelly

“…Infectious diseases are emerging and re-emerging far more frequently than many appreciate. In the past two decades alone, there have been numerous outbreaks…”
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The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization by Pisciotta, John M, Coppens, Isabelle, Tripathi, Abhai K, Scholl, Peter F, Shuman, Joel, Bajad, Sunil, Shulaev, Vladimir, Sullivan, Jr, David J

“…The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin is…”
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Erratum for Karaba et al., "Endemic Human Coronavirus Antibody Levels Are Unchanged after Convalescent or Control Plasma Transfusion for Early Outpatient COVID-19 Treatment" by Karaba, Andrew H, Johnston, Trevor S, Beck, Evan, Laeyendecker, Oliver, Cox, Andrea L, Klein, Sabra L, Sullivan, David J

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MPXV DNA kinetics in bloodstream and other body fluids samples by Meschi, Silvia, Colavita, Francesca, Carletti, Fabrizio, Mazzotta, Valentina, Matusali, Giulia, Specchiarello, Eliana, Ascoli Bartoli, Tommaso, Mondi, Annalisa, Minosse, Claudia, Giancola, Maria Letizia, Pinnetti, Carmela, Valli, Maria Beatrice, Lapa, Daniele, Mizzoni, Klizia, Sullivan, David J., Ou, Jiangda, Focosi, Daniele, Girardi, Enrico, Nicastri, Emanuele, Antinori, Andrea, Maggi, Fabrizio

“…Since spring 2022, the global epidemiology of the monkeypox virus (MPXV) has changed. The unprecedented increase of human clade II MPXV cases worldwide…”
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Timing is everything for artemisinin action by Sullivan, David J.

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SARS-CoV-2 Variants from Long-Term, Persistently Infected Immunocompromised Patients Have Altered Syncytia Formation, Temperature-Dependent Replication, and Serum Neutralizing Antibody Escape by Wouters, Camille, Sachithanandham, Jaiprasath, Akin, Elgin, Pieterse, Lisa, Fall, Amary, Truong, Thao T, Bard, Jennifer Dien, Yee, Rebecca, Sullivan, David J, Mostafa, Heba H, Pekosz, Andrew

“…SARS-CoV-2 infection of immunocompromised individuals often leads to prolonged detection of viral RNA and infectious virus in nasal specimens, presumably due…”
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Impact of Extended Duration of Artesunate Treatment on Parasitological Outcome in a Cytocidal Murine Malaria Model by Walker, Leah A, Sullivan, Jr, David J

“…Artemisinin-based combination therapies are a key pillar in global malaria control and are recommended as a first-line treatment. They rely upon a rapid…”
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