Search Results - "Sullender, Meagan"

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities by Sanson, Kendall R., Hanna, Ruth E., Hegde, Mudra, Donovan, Katherine F., Strand, Christine, Sullender, Meagan E., Vaimberg, Emma W., Goodale, Amy, Root, David E., Piccioni, Federica, Doench, John G.

“…The creation of genome-wide libraries for CRISPR knockout (CRISPRko), interference (CRISPRi), and activation (CRISPRa) has enabled the systematic interrogation…”
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Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation by Doench, John G, Hartenian, Ella, Graham, Daniel B, Tothova, Zuzana, Hegde, Mudra, Smith, Ian, Sullender, Meagan, Ebert, Benjamin L, Xavier, Ramnik J, Root, David E

“…Analysis of the genome editing activity of more than 1800 sgRNAs in mouse and human cells yields rules to facilitate design of highly active RNA guides for…”
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Norovirus interactions with the commensal microbiota by Sullender, Meagan E, Baldridge, Megan T

“…About the Authors: Meagan E. Sullender Affiliation: Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and…”
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Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens by Najm, Fadi J, Strand, Christine, Donovan, Katherine F, Hegde, Mudra, Sanson, Kendall R, Vaimberg, Emma W, Sullender, Meagan E, Hartenian, Ella, Kalani, Zohra, Fusi, Nicolo, Listgarten, Jennifer, Younger, Scott T, Bernstein, Bradley E, Root, David E, Doench, John G

“…Combinatorial CRISPR screens are improved by using Cas9 enzymes from two different organisms. Combinatorial genetic screening using CRISPR–Cas9 is a useful…”
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Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening by Orchard, Robert C, Sullender, Meagan E, Dunlap, Bria F, Balce, Dale R, Doench, John G, Virgin, Herbert W

“…Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a…”
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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 by Schnepf, Daniel, Hernandez, Pedro, Mahlakõiv, Tanel, Crotta, Stefania, Sullender, Meagan E, Peterson, Stefan T, Ohnemus, Annette, Michiels, Camille, Gentle, Ian, Dumoutier, Laure, Reis, Celso A, Diefenbach, Andreas, Wack, Andreas, Baldridge, Megan T, Staeheli, Peter

“…The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric…”
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The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor by Shaw, Teressa M., Huey, Devra, Mousa-Makky, Makky, Compaleo, Jared, Nennig, Kylie, Shah, Aadit P., Jiang, Fei, Qiu, Xueer, Klipsic, Devon, Rowland, Raymond R. R., Slukvin, Igor I., Sullender, Meagan E., Baldridge, Megan T., Li, Haichang, Warren, Cody J., Bailey, Adam L.

“…Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc…”
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A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair by Brickner, Joshua R., Soll, Jennifer M., Lombardi, Patrick M., Vågbø, Cathrine B., Mudge, Miranda C., Oyeniran, Clement, Rabe, Renana, Jackson, Jessica, Sullender, Meagan E., Blazosky, Elyse, Byrum, Andrea K., Zhao, Yu, Corbett, Mark A., Gécz, Jozef, Field, Michael, Vindigni, Alessandro, Slupphaug, Geir, Wolberger, Cynthia, Mosammaparast, Nima

“…A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex…”
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Autophagy gene-dependent intracellular immunity triggered by interferon-γ by McAllaster, Michael R, Bhushan, Jaya, Balce, Dale R, Orvedahl, Anthony, Park, Arnold, Hwang, Seungmin, Sullender, Meagan E, Sibley, L David, Virgin, Herbert W

“…Genes required for the lysosomal degradation pathway of autophagy play key roles in topologically distinct and physiologically important cellular processes…”
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Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool by Donovan, Katherine F, Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W, Johannessen, Cory M, Root, David E, Doench, John G

“…CRISPR/Cas9 screening has proven to be a versatile tool for genomics research. Based on unexpected results from a genome-wide screen, we developed a…”
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Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ by Ingle, Harshad, Lee, Sanghyun, Ai, Teresa, Orvedahl, Anthony, Rodgers, Rachel, Zhao, Guoyan, Sullender, Meagan, Peterson, Stefan T., Locke, Marissa, Liu, Ta-Chiang, Yokoyama, Christine C., Sharp, Bridgett, Schultz-Cherry, Stacey, Miner, Jonathan J., Baldridge, Megan T.

“…Commensal microbes profoundly impact host immunity to enteric viral infections 1 . We have shown that the bacterial microbiota and host antiviral cytokine…”
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Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7 by Sullender, Meagan E, Pierce, Linley R, Annaswamy Srinivas, Mridula, Crockett, Stacey L, Dunlap, Bria F, Rodgers, Rachel, Schriefer, Lawrence A, Kennedy, Elizabeth A, Stewart, Brittany M, Doench, John G, Baldridge, Megan T, Orchard, Robert C

“…Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are…”
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CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production by Zhu, Yinxing, Sullender, Meagan E., Campbell, Danielle E., Wang, Leran, Lee, Sanghyun, Kawagishi, Takahiro, Hou, Gaopeng, Dizdarevic, Alen, Jais, Philippe H., Baldridge, Megan T., Ding, Siyuan

“…Rotaviruses pose a significant threat to young children. To identify novel pro- and anti-rotavirus host factors, we performed genome-wide CRISPR/Cas9 screens…”
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Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans by McShea, Molly A., Schmidt, Kristopher L., Dubuke, Michelle L., Baldiga, Christina E., Sullender, Meagan E., Reis, Andrea L., Zhang, Subaiou, O'Toole, Sean M., Jeffers, Mary C., Warden, Rachel M., Kenney, Allison H., Gosselin, Jennifer, Kuhlwein, Mark, Hashmi, Sana K., Stringham, Eve G., Ryder, Elizabeth F.

“…Directed cell migration and process outgrowth are vital to proper development of many metazoan tissues. These processes are dependent on reorganization of the…”
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 by Doench, John G, Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W, Donovan, Katherine F, Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W, Listgarten, Jennifer, Root, David E

“…Genome-wide sgRNA libraries based on rules for on-target activity improve results of Cas9-based screens and facilitate a further refinement of on- and…”
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TRIMming viral infection: identification and characterization of the novel antiviral TRIM7 by Sullender, Meagan E, Pierce, Linley, Rodgers, Rachel, Schriefer, Lawrence, Dunlap, Bria F, Doench, John G, Orchard, Robert C, Baldridge, Megan T

“…Abstract Noroviruses (NoVs) are the leading cause of acute viral gastroenteritis worldwide, causing up to 700 million infections and 200,000 deaths annually,…”
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Viral complementation of immunodeficiency confers protection against enteric pathogens via IFN-λ by Ingle, Harshad, Lee, Sanghyun, Ai, Teresa, Orvedahl, Anthony, Rodgers, Rachel, Zhao, Guoyan, Sullender, Meagan, Peterson, Stefan T., Locke, Marissa, Liu, Ta-Chiang, Yokoyama, Christine C., Sharp, Bridgett, Schultz-Cherry, Stacey, Miner, Jonathan J., Baldridge, Megan T.

“…Commensal microbes profoundly impact host immunity to enteric viral infections 1 . We have shown that the bacterial microbiota and host antiviral cytokine…”
Get full text

Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C.elegans by McShea, Molly A., Schmidt, Kristopher L., Dubuke, Michelle L., Baldiga, Christina E., Sullender, Meagan E., Reis, Andrea L., Zhang, Subaiou, O'Toole, Sean M., Jeffers, Mary C., Warden, Rachel M., Kenney, Allison H., Gosselin, Jennifer, Kuhlwein, Mark, Hashmi, Sana K., Stringham, Eve G., Ryder, Elizabeth F.

“…Directed cell migration and process outgrowth are vital to proper development of many metazoan tissues. These processes are dependent on reorganization of the…”
Get full text