Search Results - "Sulkshane, Prasad"

The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag by Sahu, Indrajit, Mali, Sachitanand M., Sulkshane, Prasad, Xu, Cong, Rozenberg, Andrey, Morag, Roni, Sahoo, Manisha Priyadarsini, Singh, Sumeet K., Ding, Zhanyu, Wang, Yifan, Day, Sharleen, Cong, Yao, Kleifeld, Oded, Brik, Ashraf, Glickman, Michael H.

“…The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is usually found as a mixture of 30S, 26S, and 20S complexes. These…”
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Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy by Mann, Guy, Satish, Gandhesiri, Sulkshane, Prasad, Mandal, Shaswati, Glickman, Michael H, Brik, Ashraf

“…Protein post-translational modifications are involved in essentially all aspects of cellular signaling. Their dynamic nature and the difficulties in installing…”
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Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia by Sulkshane, Prasad, Ram, Jonathan, Thakur, Anita, Reis, Noa, Kleifeld, Oded, Glickman, Michael H.

“…The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely attributed to the E3 ubiquitin ligase Parkin. Here we show that in…”
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On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins by Vamisetti, Ganga B, Satish, Gandhesiri, Sulkshane, Prasad, Mann, Guy, Glickman, Michael H, Brik, Ashraf

“…The maleimide group is a widely used reagent for bioconjugation of peptides, proteins, and oligonucleotides employing Michael addition and Diels–Alder…”
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Myeloid cell leukemia-1: a formidable barrier to anticancer therapeutics and the quest of targeting it by Sulkshane, Prasad, Teni, Tanuja

“…The antiapoptotic B cell lymphoma-2 (Bcl-2) family members are apical regulators of the intrinsic pathway of apoptosis that orchestrate mitochondrial outer…”
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Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1 by Mann, Guy, Sulkshane, Prasad, Sadhu, Pradeep, Ziv, Tamar, Glickman, Michael H, Brik, Ashraf

“…Deciphering the protein posttranslational modification (PTM) code is one of the greatest biochemical challenges of our time. Phosphorylation and ubiquitylation…”
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Ubiquitination of Intramitochondrial Proteins: Implications for Metabolic Adaptability by Sulkshane, Prasad, Ram, Jonathan, Glickman, Michael H

“…Mitochondria are constantly subjected to stressful conditions due to their unique physiology and organization. The resulting damage leads to mitochondrial…”
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Elevated translationally controlled tumour protein promotes oral cancer progression and poor outcome by Sharma, Dipti, Pawar, Sagar N, Sulkshane, Prasad, Waghole, Rohit, Yasser, Mohd, Pawar, Sushil S, Kannan, Sadhana, Chaudhary, Nazia, Kalwar, Anjali, Patil, Rahul, Nair, Sudhir, Dalal, Sorab N, Teni, Tanuja

“…Translationally controlled tumour protein (TCTP) is a multifunctional protein elevated in multiple cancers. However, studies on its role in oral carcinogenesis…”
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Comparative evaluation of the clonogenic capacity of periodontal ligament fibroblasts in Hank's balanced salt solution and egg albumen: An in vitro study by Shah, Dimpi, Sulkshane, Prasad, Lalwani, Rutika, Pawar, Sagar, Teni, Tanuja, Kakade, Adesh

“…Background/Aim The type of storage media for short‐term storage of an avulsed tooth is a critical determinant for the success of tooth replantation. If…”
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BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells by Sulkshane, Prasad, Teni, Tanuja

“…We have previously reported overexpression of antiapoptotic MCL-1 protein in human oral cancers and its association with therapy resistance and poor prognosis,…”
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Identification of bicyclic compounds that act as dual inhibitors of Bcl-2 and Mcl-1 by Uthale, Abhay, Anantram, Aarti, Sulkshane, Prasad, Degani, Mariam, Teni, Tanuja

“…Elevated expression of anti-apoptotic proteins, such as Bcl-2 and Mcl-1 contributes to poor prognosis and resistance to current treatment modalities in…”
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Inhibition of proteasome reveals basal mitochondrial ubiquitination by Sulkshane, Prasad, Duek, Inbar, Ram, Jonathan, Thakur, Anita, Reis, Noa, Ziv, Tamar, Glickman, Michael H.

“…Strict quality control for mitochondrial proteins is necessary to ensure cell homeostasis. Two cellular pathways–Ubiquitin Proteasome System (UPS) and…”
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Elevated USP9X drives early-to-late-stage oral tumorigenesis via stabilisation of anti-apoptotic MCL-1 protein and impacts outcome in oral cancers by Sulkshane, Prasad, Pawar, Sagar N., Waghole, Rohit, Pawar, Sushil S., Rajput, Priyanka, Uthale, Abhay, Oak, Swapnil, Kalkar, Prajakta, Wani, Harshada, Patil, Rahul, Nair, Sudhir, Rane, Pallavi, Teni, Tanuja

“…Background Overexpression of anti-apoptotic MCL-1 protein in oral squamous cell carcinoma (OSCC) is linked to disease progression, therapy resistance and poor…”
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