Search Results - "Suliman, Hagir B."

Mitochondrial Quality Control as a Therapeutic Target by Suliman, Hagir B, Piantadosi, Claude A

“…In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium…”
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Mitochondrial Dysfunction in Lung Pathogenesis by Piantadosi, Claude A, Suliman, Hagir B

“…Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover, inflammation, and oxygen and nutrient sensing have been discovered for…”
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Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1 by Piantadosi, Claude A, Carraway, Martha Sue, Babiker, Abdelwahid, Suliman, Hagir B

“…Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we…”
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Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis by Chang, Alan L., Ulrich, Allison, Suliman, Hagir B., Piantadosi, Claude A.

“…Oxidative mitochondrial damage is closely linked to inflammation and cell death, but low levels of reactive oxygen and nitrogen species serve as signals that…”
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Activation of Mitochondrial Biogenesis by Heme Oxygenase-1-mediated NF-E2-related Factor-2 Induction Rescues Mice from Lethal Staphylococcus aureus Sepsis by CHOU MACGARVEY, Nancy, SULIMAN, Hagir B, BARTZ, Raquel R, PING FU, WITHERS, Crystal M, WELTY-WOLF, Karen E, PIANTADOSI, Claude A

“…Mitochondrial damage is an important component of multiple organ failure syndrome, a highly lethal complication of severe sepsis that lacks specific therapy…”
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Redox mechanisms of cardiomyocyte mitochondrial protection by Bartz, Raquel R, Suliman, Hagir B, Piantadosi, Claude A

“…Oxidative and nitrosative stress are primary contributors to the loss of myocardial tissue in insults ranging from ischemia/reperfusion injury from coronary…”
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Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1 by Piantadosi, Claude A., Suliman, Hagir B.

“…The nuclear expression of mitochondrial transcription factor A (Tfam), which is required for mitochondrial DNA (mtDNA) transcription and replication, must be…”
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What Is the Role of Hyperbaric Oxygen in the Management of Bisphosphonate-Related Osteonecrosis of the Jaw: A Randomized Controlled Trial of Hyperbaric Oxygen as an Adjunct to Surgery and Antibiotics by Freiberger, John J., MD, MPH, Padilla-Burgos, Rebecca, RN, McGraw, Thomas, MD, Suliman, Hagir B., PhD, Kraft, Kevin H., RN, Stolp, Bryant W., MD, Moon, Richard E., MD, Piantadosi, Claude A., MD

“…Purpose This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw…”
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Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress by Suliman, Hagir B, Piantadosi, Claude A

“…The influence of mitochondrial dysfunction on pathological states involving inflammatory and/or oxidative stress in tissues that do not show frank cellular…”
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Effects of high-intensity interval training with hyperbaric oxygen by Alvarez Villela, Miguel, Dunworth, Sophia A., Kraft, Bryan D., Harlan, Nicole P., Natoli, Michael J., Suliman, Hagir B., Moon, Richard E.

“…Hyperbaric Oxygen (HBO 2 ) has been proposed as a pre-conditioning method to enhance exercise performance. Most prior studies testing this effect have been…”
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Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism by Gutsaeva, Diana R, Carraway, Martha Sue, Suliman, Hagir B, Demchenko, Ivan T, Shitara, Hiroshi, Yonekawa, Hiromichi, Piantadosi, Claude A

“…The adaptive mechanisms that protect brain metabolism during and after hypoxia, for instance, during hypoxic preconditioning, are coordinated in part by nitric…”
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Staphylococcus aureus sepsis induces early renal mitochondrial DNA repair and mitochondrial biogenesis in mice by Bartz, Raquel R, Fu, Ping, Suliman, Hagir B, Crowley, Stephen D, MacGarvey, Nancy Chou, Welty-Wolf, Karen, Piantadosi, Claude A

“…Acute kidney injury (AKI) contributes to the high morbidity and mortality of multi-system organ failure in sepsis. However, recovery of renal function after…”
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Erythropoietin Activates Mitochondrial Biogenesis and Couples Red Cell Mass to Mitochondrial Mass in the Heart by Carraway, Martha S, Suliman, Hagir B, Jones, W. Schuyler, Chen, Chien-Wen, Babiker, Abdelwahid, Piantadosi, Claude A

“…RATIONALE:Erythropoietin (EPO) is often administered to cardiac patients with anemia, particularly from chronic kidney disease, and stimulation of…”
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GAT inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen by Demchenko, Ivan T, Suliman, Hagir B, Zhilyaey, Sergey Y, Alekseeva, Olga S, Platonova, Tatyana F, Makowski, Matthew S, Piantadosi, Claude A, Gasier, Heath G

“…Oxygen breathing at elevated partial pressures (PO 's) at or more than 3 atmospheres absolute (ATA) causes a reduction in brain γ-aminobutyric acid (GABA)…”
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Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling by Nozik-Grayck, Eva, Suliman, Hagir B, Majka, Susan, Albietz, Joseph, Van Rheen, Zachary, Roush, Kevin, Stenmark, Kurt R

“…Although production of reactive oxygen species (ROS) such as superoxide (O(2)(.-)) has been implicated in chronic hypoxia-induced pulmonary hypertension (PH)…”
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Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis by Suliman, Hagir B., Healy, Zachary, Zobi, Fabio, Kraft, Bryan D., Welty-Wolf, Karen, Smith, Joshua, Barkauskas, Christina, Piantadosi, Claude A.

“…The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. Using BLM in mice, we find low HO-1…”
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Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells by Piantadosi, Claude A., Suliman, Hagir B.

“…Nuclear respiratory factor-1 (NRF-1) is integral to the transcriptional regulation of mitochondrial biogenesis, but its control over various respiratory genes…”
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De novo Blood Biomarkers in Autism: Autoantibodies against Neuronal and Glial Proteins by Abou-Donia, Mohamed B, Suliman, Hagir B, Siniscalco, Dario, Antonucci, Nicola, ElKafrawy, Passent

“…Autism spectrum disorders (ASDs) are the most common neurodevelopmental disorders with unidentified etiology. The behavioral manifestations of ASD may be a…”
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Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis by Sweeney, Timothy E, Suliman, Hagir B, Hollingsworth, John W, Piantadosi, Claude A

“…The PGC family of transcriptional co-activators (PGC-1alpha [Ppargc1a], PGC-1beta [Ppargc1b], and PRC [Pprc]) coordinates the upregulation of mitochondrial…”
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Postlipopolysaccharide Oxidative Damage of Mitochondrial DNA by Suliman, Hagir B, Carraway, Martha S, Piantadosi, Claude A

“…Selected structural and functional alterations of mitochondria induced by bacterial lipopolysaccharide (LPS) were investigated on the basis of the hypothesis…”
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