Search Results - "Sulik, K"

The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse by Kietzman, Henry W, Everson, Joshua L, Sulik, Kathleen K, Lipinski, Robert J

“…Disruption of the Hedgehog signaling pathway has been implicated as an important molecular mechanism in the pathogenesis of fetal alcohol syndrome. In severe…”
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Genesis of alcohol-induced craniofacial dysmorphism by Sulik, Kathleen K

“…The initial diagnosis of fetal alcohol syndrome (FAS) in the United States was made because of the facial features common to the first cohort of patients. This…”
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The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos by Dong, Jian, Sulik, Kathleen K., Chen, Shao-yu

“…Reactive oxygen species (ROS) play an important role in ethanol-induced apoptosis and teratogenesis. However, the major sources of ROS in ethanol-exposed…”
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Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells by Yan, Dong, Dong, Jian, Sulik, Kathleen K., Chen, Shao-yu

“…Previous studies have shown that ethanol exposure causes apoptosis in cranial neural crest cells (NCCs), an ethanol-sensitive cell population implicated in…”
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Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology by Yang, Yaling, Roussotte, Florence, Kan, Eric, Sulik, Kathleen K, Mattson, Sarah N, Riley, Edward P, Jones, Kenneth L, Adnams, Colleen M, May, Philip A, O'Connor, Mary J, Narr, Katherine L, Sowell, Elizabeth R

“…Accumulating evidence from structural brain imaging studies on individuals with fetal alcohol spectrum disorder (FASD) has supported links between prenatal…”
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Regional brain volume reductions relate to facial dysmorphology and neurocognitive function in fetal alcohol spectrum disorders by Roussotte, Florence F., Sulik, Kathleen K., Mattson, Sarah N., Riley, Edward P., Jones, Kenneth L., Adnams, Colleen M., May, Philip A., O'Connor, Mary J., Narr, Katherine L., Sowell, Elizabeth R.

“…Individuals with heavy prenatal alcohol exposure can experience significant deficits in cognitive and psychosocial functioning and alterations in brain…”
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Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent by Lipinski, Robert J, Hammond, Peter, O'Leary-Moore, Shonagh K, Ament, Jacob J, Pecevich, Stephen J, Jiang, Yi, Budin, Francois, Parnell, Scott E, Suttie, Michael, Godin, Elizabeth A, Everson, Joshua L, Dehart, Deborah B, Oguz, Ipek, Holloway, Hunter T, Styner, Martin A, Johnson, G Allan, Sulik, Kathleen K

“…Prenatal ethanol exposure is the leading preventable cause of congenital mental disability. Whereas a diagnosis of fetal alcohol syndrome (FAS) requires…”
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Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule by Dou, Xiaowei, Wilkemeyer, Michael F., Menkari, Carrie E., Parnell, Scott E., Sulik, Kathleen K., Charness, Michael E.

“…There is a genetic contribution to fetal alcohol spectrum disorders (FASD), but the identification of candidate genes has been elusive. Ethanol may cause FASD…”
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Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse by Fujiwara, Takeshi, Dehart, Deborah B, Sulik, Kathleen K, Hogan, Brigid L M

“…In the mouse and chick embryo, the node plays a central role in generating left-right (LR) positional information. Using several different strategies, we…”
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Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate by Lipinski, Robert J, Holloway, Hunter T, O'Leary-Moore, Shonagh K, Ament, Jacob J, Pecevich, Stephen J, Cofer, Gary P, Budin, Francois, Everson, Joshua L, Johnson, G Allan, Sulik, Kathleen K

“…Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these…”
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Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome by Green, Maia L., Singh, Amar V., Zhang, Yihzi, Nemeth, Kimberly A., Sulik, Kathleen K., Knudsen, Thomas B.

“…Fetal Alcohol Spectrum Disorders (FASD) are birth defects that result from maternal alcohol use. We used a non a priori approach to prioritize candidate…”
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Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications by Lipinski, Robert J., Song, Chihwa, Sulik, Kathleen K., Everson, Joshua L., Gipp, Jerry J., Yan, Dong, Bushman, Wade, Rowland, Ian J.

“…BACKGROUND The Hedgehog (Hh) pathway provides inductive signals critical for developmental patterning of the brain and face. In humans and in animal models…”
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Differential Effects of Ethanol Antagonism and Neuroprotection in Peptide Fragment NAPVSIPQ Prevention of Ethanol-Induced Developmental Toxicity by Wilkemeyer, Michael F., Chen, Shao-yu, Menkari, Carrie E., Brenneman, Douglas E., Sulik, Kathleen K., Charness, Michael E.

“…NAPVSIPQ (NAP), an active fragment of the glial-derived activity-dependent neuroprotective protein, is protective at femtomolar concentrations against a wide…”
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Better safe than sorry by Sulik, KK, O'Leary-Moore, SK, Riley, EP

“…Please cite this paper as: Sulik K, O’Leary‐Moore S, Riley E. Better safe than sorry. BJOG 2012;119:1159–1161…”
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Essential Role of β -adrenergic Receptor Kinase 1 in Cardiac Development and Function by Jaber, Mohamed, Koch, Walter J., Rockman, Howard, Smith, Bradley, Bond, Richard A., Sulik, Kathleen K., Ross, John, Lefkowitz, Robert J., Caron, Marc G., Giros, Bruno

“…The β -adrenergic receptor kinase 1 (β ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent…”
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Selective Vulnerability of Embryonic Cell Populations to Ethanol-Induced Apoptosis: Implications for Alcohol-Related Birth Defects and Neurodevelopmental Disorder by Dunty Jr, William C., Chen, Shao-yu, Zucker, Robert M., Dehart, Deborah B., Sulik, Kathleen K.

“…Background: Ethanol‐induced cell death has been characterized in very few stages of embryogenesis. This investigation comprehensively maps patterns of both…”
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A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high by Doherty, Heather E, Kim, Hyung-Suk, Hiller, Sylvia, Sulik, Kathleen K, Maeda, Nobuyo

“…Connective tissue growth factor (CTGF) is a signaling molecule that primarily functions in extracellular matrix maintenance and repair. Increased Ctgf…”
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Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis by Niakan, Kathy K., Davis, Emily C., Clipsham, Robert C., Jiang, Meisheng, Dehart, Deborah B., Sulik, Kathleen K., McCabe, Edward R.B.

“…Cytomegalic adrenal hypoplasia congenita (AHC) is an X-linked disease caused by mutations in DAX1-encoding gene NR0B1, previously thought to function primarily…”
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Protection from ethanol‐induced limb malformations by the superoxide dismutase/catalase mimetic, EUK‐134 by Chen, Shao-yu, Dehart, Deborah B., Sulik, Kathleen K.

“…ABSTRACT Based on previous in vitro studies that have illustrated prevention of ethanol‐induced cell death by antioxidants, using an in vivo model, we have…”
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Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders by Dong, Jian, Sulik, Kathleen K, Chen, Shao-Yu

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that is important in protection against oxidative stress. This study was designed…”
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