Synthesis and bioactivity studies of novel Schiff bases and their complexes

Synthesis and bioactivity studies of novel Schiff bases and their complexes

The new Schiff base (L) “4‐[(2,4‐dimethoxy‐benzylidene)‐amino]‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydro‐pyrazol‐3‐one” was synthesized from 2,4‐dimethoxy‐benzaldehyde and 4‐amino‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydropyrazol‐3‐one, and the geometry of Schiff base was characterized and determined by proton nucle...

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Bibliographic Details
Published in:Journal of physical organic chemistry Vol. 32; no. 11
Main Authors: Al Zoubi, Wail, Jirjees, VianYamin, Suleman, VeyanTaher, Al‐Hamdani, Abbas Ali Salih, Ahmed, Suzan Duraid, Kim, Yang Gon, Ko, Young Gun
Format: Journal Article
Language:English
Published: Bognor Regis Wiley Subscription Services, Inc 01-11-2019
Subjects:
Benzaldehyde
bioactivity
Biological activity
Cadmium
complexes
Coordination compounds
Density functional theory
DFT calculations
Electronic structure
Fourier transforms
Imines
Infrared spectroscopy
Magnesium
Mercury compounds
NMR
Nuclear magnetic resonance
Palladium
Platinum
Protons
pyrazol
Schiff base
Zinc
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Summary:The new Schiff base (L) “4‐[(2,4‐dimethoxy‐benzylidene)‐amino]‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydro‐pyrazol‐3‐one” was synthesized from 2,4‐dimethoxy‐benzaldehyde and 4‐amino‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydropyrazol‐3‐one, and the geometry of Schiff base was characterized and determined by proton nuclear magnetic resonance (1H‐NMR), mass, Fourier transform infrared (FT‐IR), and ultraviolet‐visible (UV‐vis) spectroscopy. Schiff complexes of Ni(II), Pd(II), Pt(IV), Zn(II), Cd(II), and Mg(II) have been prepared by reaction of ion metals with as‐prepared Schiff base. The results showed that synthesized complexes offered 1:2 metal‐ligand ratios. Furthermore, the Schiff complexes were a tetrahedral in complexes Ni(II), Zn(II), Cd(II), and Hg(II), octahedral Pt(II), and square planer complex Pd(II). Additionally, density functional theory (DFT) was applied for calculations of both spectroscopic properties and electronic structure of prepared Schiff bases. Moreover, the Schiff base and its metal complexes have been verified in vitro against Streptococcus, Esherichia coli, Candida albicans, and Candida tropicalis in order to assess their antibacterial potential. The findings indicate that the biological activity augments on complexation reaction. The new Schiff base (L) “4‐[(2,4‐dimethoxy‐benzylidene)‐amino]‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydro‐pyrazol‐3‐one” was synthesized from 2,4‐dimethoxy‐benzaldehyde and 4‐amino‐1,5‐dimethyl‐2‐phenyl‐1,2‐dihydropyrazol‐3‐one, and the geometry of Schiff base was characterized and determined by 1H‐NMR, mass, FT‐IR, and UV‐vis spectroscopy.
ISSN:0894-3230
1099-1395
DOI:10.1002/poc.4004