Sympathetic nerve-adipocyte interactions in response to acute stress

Sympathetic nerve-adipocyte interactions in response to acute stress

Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Vol. 100; no. 2; pp. 151 - 165
Main Authors: Santos, Gabryella S. P., Costa, Alinne C., Picoli, Caroline C., Rocha, Beatriz G. S., Sulaiman, Sheu O., Radicchi, Debora C., Pinto, Mauro C. X., Batista, Miguel L., Amorim, Jaime H., Azevedo, Vasco A. C., Resende, Rodrigo R., Câmara, Niels O. S., Mintz, Akiva, Birbrair, Alexander
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2022
Springer Nature B.V
Subjects:
Adipocytes
Adipocytes - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Gluconeogenesis
Hepatocytes
Human Genetics
Humans
Inflammatory diseases
Interleukin 6
Interleukin-6 - metabolism
Internal Medicine
Microenvironments
Molecular Medicine
Molecular modelling
Review
Stress, Psychological - metabolism
Sympathetic nerves
Sympathetic Nervous System - metabolism
Therapeutic applications
Tumor Microenvironment
Sympathetic nerves
Adipocytes
Microenvironment
Hepatocytes
IL-6
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Summary:Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment.
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SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-021-02157-0