Search Results - "Sukumar, Saraswati"

Multiple roles of HOX proteins in Metastasis: Let me count the ways by Jonkers, Joy, Pai, Priya, Sukumar, Saraswati

“…Knowledge of the role of HOX proteins in cancer has been steadily accumulating in the last 25 years. They are encoded by 39 HOX genes arranged in 4 distinct…”
Get full text

Targeted nanopore sequencing with Cas9-guided adapter ligation by Gilpatrick, Timothy, Lee, Isac, Graham, James E., Raimondeau, Etienne, Bowen, Rebecca, Heron, Andrew, Downs, Bradley, Sukumar, Saraswati, Sedlazeck, Fritz J, Timp, Winston

“…Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection…”
Get full text

Unpredicted central inversion in a sgRNA flanked by inverted repeats by Wang, Guannan, Sukumar, Saraswati

“…In genome engineering, sgRNAs define the genomic target to be modified in CRISPR/Cas9 system. Either for single gene editing or genome-wide screens, sgRNAs are…”
Get full text

Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment by CONNOLLY, Roisin M, NGUYEN, Nguyen K, SUKUMAR, Saraswati

“…Retinoids and their naturally metabolized and synthetic products (e.g., all-trans retinoic acid, 13-cis retinoic acid, bexarotene) induce differentiation in…”
Get full text

Guidelines for the selection of functional assays to evaluate the hallmarks of cancer by Menyhárt, Otília, Harami-Papp, Hajnalka, Sukumar, Saraswati, Schäfer, Reinhold, Magnani, Luca, de Barrios, Oriol, Győrffy, Balázs

“…The hallmarks of cancer capture the most essential phenotypic characteristics of malignant transformation and progression. Although numerous factors involved…”
Get full text

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis by Lee, Esak, Fertig, Elana J., Jin, Kideok, Sukumar, Saraswati, Pandey, Niranjan B., Popel, Aleksander S.

“…Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial…”
Get full text

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters by Wong, David J, Chang, Howard Y, Hung, Tiffany, Wang, Yulei, Lin, Michael F, Koegel, Ashley K, Kotake, Yojiro, Grant, Gavin D, Horlings, Hugo M, Shah, Nilay, Umbricht, Christopher, Wang, Pei, Wang, Yu, Kong, Benjamin, Langerød, Anita, Børresen-Dale, Anne-Lise, Kim, Seung K, van de Vijver, Marc, Sukumar, Saraswati, Whitfield, Michael L, Kellis, Manolis, Xiong, Yue

“…David Wong, Howard Chang and colleagues report the identification of long noncoding RNAs transcribed from the promoters of cell cycle genes. Many of these RNAs…”
Get full text

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition by DINGCHENG GAO, JOSHI, Natasha, PORT, Jeffrey L, STILES, Brendon, SUKUMAR, Saraswati, ALTORKI, Nasser K, RAFII, Shahin, MITTAL, Vivek, CHOI, Hyejin, RYU, Seongho, HAHN, Mary, CATENA, Raul, SADIK, Helen, ARGANI, Pedram, WAGNER, Patrick, VAHDAT, Linda T

“…Tumors systemically initiate metastatic niches in distant target metastatic organs. These niches, composed of bone marrow-derived hematopoietic cells, provide…”
Get full text

The Widening Sphere of Influence of HOXB7 in Solid Tumors by Errico, Maria Cristina, Jin, Kideok, Sukumar, Saraswati, Carè, Alessandra

“…Strong lines of evidence have established a critical role for the homeodomain protein HOXB7 in cancer. Specifically, molecular and cellular studies have…”
Get full text

DNA methylation regulates microRNA expression by Han, Liangfeng, Witmer, P. Dane Witmer, Casey, Emily, Valle, David, Sukumar, Saraswati

“…MicroRNAs (miRNAs), an important class of small regulatory molecules for gene expression, are transcribed by RNA polymerase II. But little is known about the…”
Get full text

Novel Methylated Biomarkers and a Robust Assay to Detect Circulating Tumor DNA in Metastatic Breast Cancer by FACKLER, Mary Jo, LOPEZ BUJANDA, Zoila, LYMAN, Jaclyn P, DE BROT, Marina, INGLE, James N, BOUGHEY, Judy, McGUIRE, Kandace, KING, Tari A, CAREY, Lisa A, COPE, Leslie, WOLFF, Antonio C, SUKUMAR, Saraswati, UMBRICHT, Christopher, WEI WEN TEO, SOONWENG CHO, ZHE ZHANG, VISVANATHAN, Kala, JETER, Stacie, ARGANI, Pedram, CHENGUANG WANG

“…The ability to consistently detect cell-free tumor-specific DNA in peripheral blood of patients with metastatic breast cancer provides the opportunity to…”
Get full text

Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence by JO FACKLER, Mary, UMBRICHT, Christopher B, MARKS, Jeffrey, ETHIER, Stephen, GRAY, Joe W, WOLFF, Antonio C, COPE, Leslie M, SUKUMAR, Saraswati, WILLIAMS, Danielle, ARGANI, Pedram, CRUZ, Leigh-Ann, MERINO, Vanessa F, WEI WEN TEO, ZHE ZHANG, PENG HUANG, VISVANANTHAN, Kala

“…To better understand the biology of hormone receptor-positive and-negative breast cancer and to identify methylated gene markers of disease progression, we…”
Get full text

CRYβB2 enhances tumorigenesis through upregulation of nucleolin in triple negative breast cancer by Yan, Yu, Narayan, Athira, Cho, Soonweng, Cheng, Zhiqiang, Liu, Jun O., Zhu, Heng, Wang, Guannan, Wharram, Bryan, Lisok, Ala, Brummet, Mary, Saeki, Harumi, Huang, Tao, Gabrielson, Kathleen, Gabrielson, Edward, Cope, Leslie, Kanaan, Yasmine M., Afsari, Ali, Naab, Tammey, Yfantis, Harris G., Ambs, Stefan, Pomper, Martin G., Sukumar, Saraswati, Merino, Vanessa F.

“…Expression of β-crystallin B2 (CRYβB2) is elevated in African American (AA) breast tumors. The underlying mechanisms of CRYβB2-induced malignancy and the…”
Get full text

HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells by Shah, Sandeep N, Cope, Leslie, Poh, Weijie, Belton, Amy, Roy, Sujayita, Talbot, Jr, C Conover, Sukumar, Saraswati, Huso, David L, Resar, Linda M S

“…Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process…”
Get full text

Intraductal Therapy in Breast Cancer: Current Status and Future Prospective by Kuang, Xin-Wen, Liu, Jian-Hua, Sun, Zhi-Hong, Sukumar, Saraswati, Sun, Sheng-Rong, Chen, Chuang

“…With our improved understanding of the biological behavior of breast cancer, minimally invasive intervention is urgently needed for personalized treatment of…”
Get full text

Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer by Merino, Vanessa F, Cho, Soonweng, Nguyen, Nguyen, Sadik, Helen, Narayan, Athira, Talbot, Jr, Conover, Cope, Leslie, Zhou, Xian C, Zhang, Zhe, Győrffy, Balázs, Sukumar, Saraswati

“…A combination of entinostat, all-trans retinoic acid, and doxorubicin (EAD) induces cell death and differentiation and causes significant regression of…”
Get full text

HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition by XINYAN WU, HEXIN CHEN, PARKER, Belinda, RUBIN, Ethel, TAO ZHU, JI SHIN LEE, ARGANI, Pedram, SUKUMAR, Saraswati

“…Epithelial-mesenchymal transition (EMT) is increasingly recognized as a mechanism whereby cells in primary noninvasive tumors acquire properties essential for…”
Get full text

Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients by Avraham, Ayelet, Uhlmann, Ronit, Shperber, Aino, Birnbaum, Miriam, Sandbank, Judith, Sella, Avishay, Sukumar, Saraswati, Evron, Ella

“…Patients with large or nonoperable breast cancers often receive neoadjuvant chemotherapy to facilitate full resection of the tumor and enable conservation of…”
Get full text

HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway by Jin, Kideok, Kong, Xiangjun, Shah, Tariq, Penet, Marie-France, Wildes, Flonne, Sgroi, Dennis C, Ma, Xiao-Jun, Huang, Yi, Kallioniemi, Anne, Landberg, Goran, Bieche, Ivan, Wu, Xinyan, Lobie, Peter E, Davidson, Nancy E, Bhujwalla, Zaver M, Zhu, Tao, Sukumar, Saraswati

“…Multiple factors including long-term treatment with tamoxifen are involved in the development of selective estrogen receptor (ER) modulator resistance in…”
Get full text

The Mammalian Ortholog of Drosophila MOF That Acetylates Histone H4 Lysine 16 Is Essential for Embryogenesis and Oncogenesis by Gupta, Arun, Guerin-Peyrou, T. Geraldine, Sharma, Girdhar G., Park, Changwon, Agarwal, Manjula, Ganju, Ramesh K., Pandita, Shruti, Choi, Kyunghee, Sukumar, Saraswati, Pandita, Raj K., Ludwig, Thomas, Pandita, Tej K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text