Search Results - "Sukoff, S J"

Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics by Silverman, J.L., Nithianantharajah, J., Der-Avakian, A., Young, J.W., Sukoff Rizzo, S.J.

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Validation and in vivo characterization of research antibodies for Moesin, CD44, Midkine, and sFRP-1. [version 2; peer review: 2 approved with reservations] by Doolen, Suzanne, Ayoubi, Riham, Laflamme, Carl, Betarbet, Ranjita, Zoeller, Elizabeth, Williams, Sean-Paul G., Fu, Haian, Levey, Allan I., Sukoff Rizzo, S. J.

“…Background A major goal of the Target Enablement to Accelerate Therapy Development for Alzheimer's disease (TREAT-AD) program is to develop and identify…”
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Behavioral characterization of striatal‐enriched protein tyrosine phosphatase (STEP) knockout mice by Sukoff Rizzo, S. J., Lotarski, S. M., Stolyar, P., McNally, T., Arturi, C., Roos, M., Finley, J. E., Reinhart, V., Lanz, T. A.

“…Striatal‐enriched protein tyrosine phosphatase (STEP) has been described as a regulator of multiple kinases and glutamate receptor subunits critical for…”
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Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties by Schechter, L E, Smith, D L, Rosenzweig-Lipson, S, Sukoff, S J, Dawson, L A, Marquis, K, Jones, D, Piesla, M, Andree, T, Nawoschik, S, Harder, J A, Womack, M D, Buccafusco, J, Terry, A V, Hoebel, B, Rada, P, Kelly, M, Abou-Gharbia, M, Barrett, J E, Childers, W

“…Recent data has suggested that the 5-hydroxytryptamine (5-HT)(1A) receptor is involved in cognitive processing. A novel 5-HT(1A) receptor antagonist,…”
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Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice by Gonzales, C., Zaleska, M.M., Riddell, D.R., Atchison, K.P., Robshaw, A., Zhou, H., Sukoff Rizzo, S.J.

“…Development of novel therapeutic agents aimed at treating neurodegenerative disorders such as Alzheimer's and Parkinson's diseases require chronic and…”
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Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression by Hughes, Z.A., Neal, S.J., Smith, D.L., Sukoff Rizzo, S.J., Pulicicchio, C.M., Lotarski, S., Lu, S., Dwyer, J.M., Brennan, J., Olsen, M., Bender, C.N., Kouranova, E., Andree, T.H., Harrison, J.E., Whiteside, G.T., Springer, D., O'Neil, S.V., Leonard, S.K., Schechter, L.E., Dunlop, J., Rosenzweig-Lipson, S., Ring, R.H.

“…Evidence suggests that 30–50% of patients suffering from major depressive disorder (MDD) are classified as suffering from treatment resistant depression (TRD)…”
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Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes by Sukoff Rizzo, S J, Neal, S J, Hughes, Z A, Beyna, M, Rosenzweig-Lipson, S, Moss, S J, Brandon, N J

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Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes by Sukoff Rizzo, S J, Neal, S J, Hughes, Z A, Beyna, M, Rosenzweig-Lipson, S, Moss, S J, Brandon, N J

“…There is compelling clinical literature implicating a role for cytokines in the pathophysiology of major depressive disorder (MDD). Interleukin-6 (IL-6) and…”
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Anxiolytic-like activity of the mGluR5 antagonist MPEP: A comparison with diazepam and buspirone by Brodkin, Jesse, Busse, Chris, Sukoff, Stacey J, Varney, Mark A

“…The selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), 2-methyl-6-(phenylethynyl)pyridine (MPEP) was…”
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Validation and in vivo characterization of research antibodies for Moesin, CD44, Midkine, and sFRP-1. [version 1; peer review: awaiting peer review] by Doolen, Suzanne, Ayoubi, Riham, Laflamme, Carl, Betarbet, Ranjita, Zoeller, Elizabeth, Williams, Sean-Paul G., Fu, Haian, Levey, Allan I., Sukoff Rizzo, S. J.

“…Background: A major goal of the Target Enablement to Accelerate Therapy Development for Alzheimer's disease (TREAT-AD) program is to develop and identify…”
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The acoustic startle reflex in Sprague-Dawley rats is altered by permanent middle cerebral artery occlusion by Maynard, Kenneth I., Sukoff, Stacey J., Ji, Zhongqi, Wettstein, Joseph G., Black, Mark D.

“…The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was…”
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Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity by Brandt, Michael R, Cummons, Terri A, Potestio, Lisa, Sukoff, Stacey J, Rosenzweig-Lipson, Sharon

“…Perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] is a selective, competitive N-methyl-D-aspartate (NMDA)…”
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Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon by Rajarao, S. Johannes R, Platt, Brian, Sukoff, Stacey J, Lin, Qian, Bender, Corey N, Nieuwenhuijsen, Bart W, Ring, Robert H, Schechter, Lee E, Rosenzweig-Lipson, Sharon, Beyer, Chad E

“…Abstract Galanin’s influence on monoaminergic neurotransmission, together with its discrete CNS distribution in corticolimbic brain areas, points to a…”
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Exercise prevents obesity-induced cognitive decline and white matter damage in mice by Graham, Leah C., Grabowska, Weronika A., Chun, Yoona, Risacher, Shannon L., Philip, Vivek M., Saykin, Andrew J., Sukoff Rizzo, Stacey J., Howell, Gareth R.

“…Obesity in the western world has reached epidemic proportions, and yet the long-term effects on brain health are not well understood. To address this, we…”
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Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT sub(1A) Antagonists: The Discovery of Lecozotan by Childers, WE Jr, Abou-Gharbia, MA, Kelly, M G, Andree, TH, Harrison, B L, Ho, D M, Hornby, G, Huryn, D M, Potestio, L, Rosenzweig-Lipson, S J, Schmid, J, Smith, D L, Sukoff, S J, Zhang, G, Schechter, LE

“…A series of benzodioxanylpiperazine derivatives possessing a 4-aryl amide substituent was prepared and evaluated for 5-HT sub(1A) affinity and functional…”
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Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists:  The Discovery of Lecozotan by Childers, Wayne E, Abou-Gharbia, Magid A, Kelly, Michael G, Andree, Terrance H, Harrison, Boyd L, Ho, Douglas M, Hornby, Geoffrey, Huryn, Donna M, Potestio, Lisa, Rosenzweig-Lipson, Sharon J, Schmid, Jean, Smith, Deborah L, Sukoff, Stacey J, Zhang, Gan, Schechter, Lee E

“…A series of benzodioxanylpiperazine derivatives possessing a 4-aryl amide substituent was prepared and evaluated for 5-HT1A affinity and functional antagonist…”
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