Search Results - "Sukkar, Maria"

RAGE and TLRs: Relatives, friends or neighbours? by Ibrahim, Zaridatul Aini, Armour, Carol L., Phipps, Simon, Sukkar, Maria B.

“…•RAGE and TLRs play a critical role in host defence.•Mechanisms of their discriminate or co-interaction with common ligands are unknown.•Understanding of their…”
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The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease by Wong, Sharon L I, Sukkar, Maria B

“…The SPARC (secreted protein acidic and rich in cysteine) protein is matricellular molecule regulating interactions between cells and their surrounding…”
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Autophagy and inflammasomes by Harris, James, Lang, Tali, Thomas, Jacinta P.W., Sukkar, Maria B., Nabar, Neel R., Kehrl, John H.

“…•Loss of autophagy increases inflammasome activation.•Autophagy removes inflammasome-activating stimuli from the cytosol.•Autophagy degrades inflammasome…”
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Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation by Ullah, Md Ashik, M Pharm, Loh, Zhixuan, B Biomed Sci, Gan, Wan Jun, B Biomed Sci, Zhang, Vivian, PhD, Yang, Huan, PhD, Li, Jian Hua, PhD, Yamamoto, Yasuhiko, PhD, Schmidt, Ann Marie, PhD, Armour, Carol L., PhD, Hughes, J. Margaret, PhD, Phipps, Simon, PhD, Sukkar, Maria B., PhD

“…Background The receptor for advanced glycation end products (RAGE) shares common ligands and signaling pathways with TLR4, a key mediator of house dust mite (…”
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HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling by Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J, Lynch, Jason P, Werder, Rhiannon B, Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B, Sly, Peter D, Steptoe, Raymond J, Spann, Kirsten M, Sukkar, Maria B, Upham, John W, Phipps, Simon, Heise, Mark T

“…Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe…”
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Development of an adaptation framework to implement a new professional pharmacy service (PPS) to a new environment by Aly, Mariyam, Schneider, Carl R., Sukkar, Maria B., Lucas, Cherie

“…The effective provision of professional pharmacy services is critical to support the delivery of primary health care. Structured frameworks and theoretical…”
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TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells by Michaeloudes, Charalambos, Sukkar, Maria B, Khorasani, Nadia M, Bhavsar, Pankaj K, Chung, Kian Fan

“…Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism, mainly through the mitochondria and peroxisomes, but their release is…”
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Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation by Ullah, Md Ashik, MPharm, Revez, Joana A., BSci, Loh, Zhixuan, B Biomed Sci, Simpson, Jennifer, B Biomed Sci, Zhang, Vivian, PhD, Bain, Lisa, BSci, Varelias, Antiopi, PhD, Rose-John, Stefan, PhD, Blumenthal, Antje, PhD, Smyth, Mark J., PhD, Hill, Geoffrey R., MD, Sukkar, Maria B., PhD, Ferreira, Manuel A.R., PhD, Phipps, Simon, PhD

“…Background A variant in the IL-6 receptor (IL-6R) gene increases asthma risk and is predicted to decrease IL-6 classic signaling and increase IL-6…”
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Development of a Soluplus budesonide freeze-dried powder for nasal drug delivery by Pozzoli, Michele, Traini, Daniela, Young, Paul M., Sukkar, Maria B., Sonvico, Fabio

“…Objective: The aim of this work was to develop an amorphous solid dispersions/solutions (ASD) of a poorly soluble drug, budesonide (BUD) with a novel polymer…”
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RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury by Seyed Hosseini Fin, Nafiseh, Georgevsky, Dana, Sukkar, Maria B, Golzan, S Mojtaba

“…Glaucoma is a progressive neurodegenerative disease associated with age. Accumulation of amyloid-beta (Aß) proteins in the ganglion cell layer (GCL) and…”
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Allergen-induced IL-6 trans-signaling activates gamma delta T cells to promote type 2 and type 17 airway inflammation by Ullah, Md Ashik, Revez, Joana A, Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J, Hill, Geoffrey R, Sukkar, Maria B, Ferreira, Manuel AR, Phipps, Simon

“…Background A variant in the IL-6 receptor (IL-6R) gene increases asthma risk and is predicted to decrease IL-6 classic signaling and increase IL-6…”
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RAGE: a new frontier in chronic airways disease by Sukkar, Maria B, Ullah, Md Ashik, Gan, Wan Jun, Wark, Peter AB, Chung, Kian Fan, Hughes, J Margaret, Armour, Carol L, Phipps, Simon

“…Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous inflammatory disorders of the respiratory tract characterized by airflow obstruction…”
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Potential impact of oxidative stress induced growth inhibitor 1 (OSGIN1) on airway epithelial cell autophagy in chronic obstructive pulmonary disease (COPD) by Sukkar, Maria B, Harris, James

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Exploration of health professional stakeholders’ views and experiences regarding minor ailments services’ education, training and assessment by Aly, Mariyam, Schneider, Carl R., Sukkar, Maria B., Lucas, Cherie

“…Background Minor ailments services are structured pharmacy-based primary health care services that manage minor conditions. Limited training, education and…”
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RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD by Allam, Venkata Sita Rama Raju, Faiz, Alen, Lam, Maggie, Rathnayake, Senani N. H., Ditz, Benedikt, Pouwels, Simon D., Brandsma, Corry‐Anke, Timens, Wim, Hiemstra, Pieter S., Tew, Gaik W., Neighbors, Margaret, Grimbaldeston, Michele, van den Berge, Maarten, Donnelly, Sheila, Phipps, Simon, Bourke, Jane E., Sukkar, Maria B.

“…Background The receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4) is implicated in COPD. Although these receptors share common…”
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Educational needs of community pharmacy staff in minor ailment service delivery: A systematic scoping review by Aly, Mariyam, Schneider, Carl R., Sukkar, Maria B., Lucas, Cherie

“…Minor ailment services (MASs) are structured, protocol driven pharmacy services established locally or nationally. Community pharmacy staff may benefit from…”
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The nasal delivery of nanoencapsulated statins - an approach for brain delivery by Clementino, Adryana, Batger, Mellissa, Garrastazu, Gabriela, Pozzoli, Michele, Del Favero, Elena, Rondelli, Valeria, Gutfilen, Bianca, Barboza, Thiago, Sukkar, Maria B, Souza, Sergio A L, Cantù, Laura, Sonvico, Fabio

“…Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases…”
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Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta by Xie, Shaoping, Sukkar, Maria B, Issa, Razao, Khorasani, Nadia M, Chung, Kian Fan

“…Airway smooth muscle (ASM) hyperplasia is a characteristic feature of the asthmatic airway, but the underlying mechanisms that induce ASM hyperplasia remain…”
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Establishing consensus for the education, training and assessment requirements of community pharmacy staff to deliver minor ailments services: A modified Delphi study by Aly, Mariyam, Schneider, Carl R., Sukkar, Maria B., Lucas, Cherie

“…Minor ailments services (MASs) are pharmacy-based and support individuals to manage minor conditions. MASs are delivered by community pharmacists and…”
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Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis by Wong, Sharon L, To, Joyce, Santos, Jerran, Allam, Venkata Sita Rama Raju, Dalton, John P, Djordjevic, Steven P, Donnelly, Sheila, Padula, Matthew P, Sukkar, Maria B

“…The release of damage-associated molecular patterns (DAMPs) by airway epithelial cells is believed to play a crucial role in the initiation and development of…”
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