Search Results - "Suhre, Karsten"

Metabolic profiling in diabetes by Suhre, Karsten

“…Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This…”
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Genetics meets proteomics: perspectives for large population-based studies by Suhre, Karsten, McCarthy, Mark I., Schwenk, Jochen M.

“…Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the complex processes influencing human biology. Proteins represent…”
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Genetic variation in metabolic phenotypes: study designs and applications by Suhre, Karsten, Gieger, Christian

“…Key Points Technical advances in mass spectrometry and NMR spectroscopy enable genome-wide screens to be carried out for the association between genetic…”
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SNiPA: an interactive, genetic variant-centered annotation browser by Arnold, Matthias, Raffler, Johannes, Pfeufer, Arne, Suhre, Karsten, Kastenmüller, Gabi

“…Linking genes and functional information to genetic variants identified by association studies remains difficult. Resources containing extensive genomic…”
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Revealing the role of the human blood plasma proteome in obesity using genetic drivers by Zaghlool, Shaza B., Sharma, Sapna, Molnar, Megan, Matías-García, Pamela R., Elhadad, Mohamed A., Waldenberger, Melanie, Peters, Annette, Rathmann, Wolfgang, Graumann, Johannes, Gieger, Christian, Grallert, Harald, Suhre, Karsten

“…Blood circulating proteins are confounded readouts of the biological processes that occur in different tissues and organs. Many proteins have been linked to…”
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Metabolomics platforms for genome wide association studies—linking the genome to the metabolome by Adamski, Jerzy, Suhre, Karsten

“…Graphical abstract Highlights ► Genome-wide association studies with metabolomics constitute mGWAS. ► mGWAS provide insights into genetic and environmental…”
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Connecting genetic risk to disease end points through the human blood plasma proteome by Suhre, Karsten, Arnold, Matthias, Bhagwat, Aditya Mukund, Cotton, Richard J., Engelke, Rudolf, Raffler, Johannes, Sarwath, Hina, Thareja, Gaurav, Wahl, Annika, DeLisle, Robert Kirk, Gold, Larry, Pezer, Marija, Lauc, Gordan, El-Din Selim, Mohammed A., Mook-Kanamori, Dennis O., Al-Dous, Eman K., Mohamoud, Yasmin A., Malek, Joel, Strauch, Konstantin, Grallert, Harald, Peters, Annette, Kastenmüller, Gabi, Gieger, Christian, Graumann, Johannes

“…Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease…”
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease by Yao, Chen, Chen, George, Song, Ci, Keefe, Joshua, Mendelson, Michael, Huan, Tianxiao, Sun, Benjamin B., Laser, Annika, Maranville, Joseph C., Wu, Hongsheng, Ho, Jennifer E., Courchesne, Paul, Lyass, Asya, Larson, Martin G., Gieger, Christian, Graumann, Johannes, Johnson, Andrew D., Danesh, John, Runz, Heiko, Hwang, Shih-Jen, Liu, Chunyu, Butterworth, Adam S., Suhre, Karsten, Levy, Daniel

“…Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants…”
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ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci by Stacey, David, Fauman, Eric B, Ziemek, Daniel, Sun, Benjamin B, Harshfield, Eric L, Wood, Angela M, Butterworth, Adam S, Suhre, Karsten, Paul, Dirk S

“…Abstract Quantitative trait locus (QTL) mapping of molecular phenotypes such as metabolites, lipids and proteins through genome-wide association studies…”
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Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects by Kahal, Hassan, Halama, Anna, Aburima, Ahmed, Bhagwat, Aditya M., Butler, Alexandra E., Graumann, Johannes, Suhre, Karsten, Sathyapalan, Thozhukat, Atkin, Stephen L.

“…Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); this has been suggested to be due to increased hypoglycemia…”
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies by Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan

“…Background Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in…”
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Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix by Torres, Maria F., Mathew, Lisa S., Ahmed, Ikhlak, Al-Azwani, Iman K., Krueger, Robert, Rivera-Nuñez, Diego, Mohamoud, Yasmin A., Clark, Andrew G., Suhre, Karsten, Malek, Joel A.

“…The date palm tree is a commercially important member of the genus Phoenix whose 14 species are dioecious with separate male and female individuals. To…”
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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans by Schlosser, Pascal, Li, Yong, Sekula, Peggy, Raffler, Johannes, Grundner-Culemann, Franziska, Pietzner, Maik, Cheng, Yurong, Wuttke, Matthias, Steinbrenner, Inga, Schultheiss, Ulla T., Kotsis, Fruzsina, Kacprowski, Tim, Forer, Lukas, Hausknecht, Birgit, Ekici, Arif B., Nauck, Matthias, Völker, Uwe, Walz, Gerd, Oefner, Peter J., Kronenberg, Florian, Mohney, Robert P., Köttgen, Michael, Suhre, Karsten, Eckardt, Kai-Uwe, Kastenmüller, Gabi, Köttgen, Anna

“…The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites…”
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Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data by Krumsiek, Jan, Suhre, Karsten, Illig, Thomas, Adamski, Jerzy, Theis, Fabian J

“…With the advent of high-throughput targeted metabolic profiling techniques, the question of how to interpret and analyze the resulting vast amount of data…”
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MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data by Wägele, Brigitte, Witting, Michael, Schmitt-Kopplin, Philippe, Suhre, Karsten

“…Systems Biology is a field in biological science that focuses on the combination of several or all "omics"-approaches in order to find out how genes,…”
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Differences between human plasma and serum metabolite profiles by Yu, Zhonghao, Kastenmüller, Gabi, He, Ying, Belcredi, Petra, Möller, Gabriele, Prehn, Cornelia, Mendes, Joaquim, Wahl, Simone, Roemisch-Margl, Werner, Ceglarek, Uta, Polonikov, Alexey, Dahmen, Norbert, Prokisch, Holger, Xie, Lu, Li, Yixue, Wichmann, H-Erich, Peters, Annette, Kronenberg, Florian, Suhre, Karsten, Adamski, Jerzy, Illig, Thomas, Wang-Sattler, Rui

“…Human plasma and serum are widely used matrices in clinical and biological studies. However, different collecting procedures and the coagulation cascade…”
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population by Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S, Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A, Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J, Valdes, Ana M, Meisinger, Christa, Coresh, Josef, Spector, Tim D, Mohney, Robert P, Suhre, Karsten, Kastenmüller, Gabi, Köttgen, Anna

“…Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and…”
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Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach by MENNI, Cristina, FAUMAN, Eric, WEI YUAN, MILBURN, Mike, PALMER, Colin N. A, FRAYLING, Timothy M, TRIMMER, Jeff, BELL, Jordana T, GIEGER, Christian, MOHNEY, Rob P, BROSNAN, Mary Julia, SUHRE, Karsten, ERTE, Idil, SORANZO, Nicole, SPECTOR, Tim D, PERRY, John R. B, KASTENMÜLLER, Gabi, SHIN, So-Youn, PETERSEN, Ann-Kristin, HYDE, Craig, PSATHA, Maria, WARD, Kirsten J

“…Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we searched for novel molecular markers that arise before and after hyperglycemia…”
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Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population by Zaghlool, Shaza B., Halama, Anna, Stephan, Nisha, Gudmundsdottir, Valborg, Gudnason, Vilmundur, Jennings, Lori L., Thangam, Manonanthini, Ahlqvist, Emma, Malik, Rayaz A., Albagha, Omar M. E., Abou‑Samra, Abdul Badi, Suhre, Karsten

“…Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression, treatment, and complications. A data driven cluster analysis in European…”
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Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting by Suhre, Karsten, Meisinger, Christa, Döring, Angela, Altmaier, Elisabeth, Belcredi, Petra, Gieger, Christian, Chang, David, Milburn, Michael V, Gall, Walter E, Weinberger, Klaus M, Mewes, Hans-Werner, Hrabé de Angelis, Martin, Wichmann, H-Erich, Kronenberg, Florian, Adamski, Jerzy, Illig, Thomas

“…Metabolomics is the rapidly evolving field of the comprehensive measurement of ideally all endogenous metabolites in a biological fluid. However, no single…”
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