Search Results - "Suhoski, Megan M."

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains by Carpenito, Carmine, Milone, Michael C, Hassan, Raffit, Simonet, Jacqueline C, Lakhal, Mehdi, Suhoski, Megan M, Varela-Rohena, Angel, Haines, Kathleen M, Heitjan, Daniel F, Albelda, Steven M, Carroll, Richard G, Riley, James L, Pastan, Ira, June, Carl H

“…Mesothelin is a cell-surface molecule over-expressed on a large fraction of carcinomas, and thus is an attractive target of immunotherapy. A molecularly…”
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Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency by Moraga, Ignacio, Richter, David, Wilmes, Stephan, Winkelmann, Hauke, Jude, Kevin, Thomas, Christoph, Suhoski, Megan M, Engleman, Edgar G, Piehler, Jacob, Garcia, K Christopher

“…Cytokines dimerize cell surface receptors to activate signaling and regulate many facets of the immune response. Many cytokines have pleiotropic effects,…”
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4-1BB Is Superior to CD28 Costimulation for Generating CD8+ Cytotoxic Lymphocytes for Adoptive Immunotherapy by Zhang, Hua, Snyder, Kristen M, Suhoski, Megan M, Maus, Marcela V, Kapoor, Veena, June, Carl H, Mackall, Crystal L

“…Artificial APCs (aAPCs) genetically modified to express selective costimulatory molecules provide a reproducible, cost-effective, and convenient method for…”
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Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes by Ye, Qunrui, Loisiou, Maria, Levine, Bruce L, Suhoski, Megan M, Riley, James L, June, Carl H, Coukos, George, Powell, Jr, Daniel J

“…Development of a standardized platform for the rapid expansion of tumor-infiltrating lymphocytes (TILs) with anti-tumor function from patients with limited TIL…”
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Th17 cells induce Th1-polarizing monocyte-derived dendritic cells by Davidson, Matthew G, Alonso, Michael N, Yuan, Robert, Axtell, Robert C, Kenkel, Justin A, Suhoski, Megan M, González, Joseph C, Steinman, Lawrence, Engleman, Edgar G

“…In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study…”
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In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells by Davidson, Matthew G, Alonso, Michael N, Kenkel, Justin A, Suhoski, Megan M, González, Joseph C, Yuan, Robert, Engleman, Edgar G

“…Two critical functions of dendritic cells (DC) are to activate and functionally polarize T cells. Activated T cells can, in turn, influence DC maturation,…”
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How do i participate in T‐cell immunotherapy? by Suhoski Davis, Megan M., McKenna, David H., Norris, Philip J.

“…T cells play a key role in the adaptive immune response, and the ability to manipulate T cells for therapeutic uses has advanced in the past decade. Infusion…”
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Nonviral RNA chimeric antigen receptor–modified T cells in patients with Hodgkin lymphoma by Svoboda, Jakub, Rheingold, Susan R., Gill, Saar I., Grupp, Stephan A., Lacey, Simon F., Kulikovskaya, Irina, Suhoski, Megan M., Melenhorst, J. Joseph, Loudon, Brandon, Mato, Anthony R., Nasta, Sunita Dwivedy, Landsburg, Daniel J., Youngman, Matthew R., Levine, Bruce L., Porter, David L., June, Carl H., Schuster, Stephen J.

“…Chimeric antigen receptor (CAR)–modified T cells are being investigated in many settings, including classical Hodgkin lymphoma (cHL). The unique biology of…”
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The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells by Paulos, Chrystal M, Carpenito, Carmine, Plesa, Gabriela, Suhoski, Megan M, Varela-Rohena, Angel, Golovina, Tatiana N, Carroll, Richard G, Riley, James L, June, Carl H

“…Human T helper 17 (T(H)17) cells regulate host defense, autoimmunity, and tumor immunity. Although cytokines that control human T(H)17 cell development have…”
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Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor by Jakobsen, Bent K, Riley, James L, Varela-Rohena, Angel, Molloy, Peter E, Dunn, Steven M, Li, Yi, Suhoski, Megan M, Carroll, Richard G, Milicic, Anita, Mahon, Tara, Sutton, Deborah H, Laugel, Bruno, Moysey, Ruth, Cameron, Brian J, Vuidepot, Annelise, Purbhoo, Marco A, Cole, David K, Phillips, Rodney E, June, Carl H, Sewell, Andrew K

“…In HIV research, new types of reagents are needed to target infected cells and overcome HIV's ability to vary its HLA-I-restricted antigens and escape from…”
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Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines by Junttila, Ilkka S, Creusot, Remi J, Moraga, Ignacio, Bates, Darren L, Wong, Michael T, Alonso, Michael N, Suhoski, Megan M, Lupardus, Patrick, Meier-Schellersheim, Martin, Engleman, Edgar G, Utz, Paul J, Fathman, C Garrison, Paul, William E, Garcia, K Christopher

“…The creation and application of engineered constructs specific for one of two IL-4 coreceptors explain how immune signaling is limited by coreceptor…”
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Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse by Banerjee, Pinaki P, Pandey, Rahul, Zheng, Rena, Suhoski, Megan M, Monaco-Shawver, Linda, Orange, Jordan S

“…An essential function of the immunological synapse (IS) is directed secretion. NK cells are especially adept at this activity, as they direct lytic granules to…”
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CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function by Golovina, Tatiana N, Mikheeva, Tatiana, Suhoski, Megan M, Aqui, Nicole A, Tai, Victoria C, Shan, Xiaochuan, Liu, Ronghua, Balcarcel, R. Robert, Fisher, Nancy, Levine, Bruce L, Carroll, Richard G, Warner, Noel, Blazar, Bruce R, June, Carl H, Riley, James L

“…The costimulatory requirements required for peripheral blood T regulatory cells (Tregs) are unclear. Using cell-based artificial APCs we found that CD28 but…”
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Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells by Hippen, Keli L., Harker-Murray, Paul, Porter, Stephen B., Merkel, Sarah C., Londer, Aryel, Taylor, Dawn K., Bina, Megan, Panoskaltsis-Mortari, Angela, Rubinstein, Pablo, Van Rooijen, Nico, Golovina, Tatiana N., Suhoski, Megan M., Miller, Jeffrey S., Wagner, John E., June, Carl H., Riley, James L., Blazar, Bruce R.

“…Previously, we showed that human umbilical cord blood (UCB) regulatory T cells (Tregs) could be expanded approximately 100-fold using anti-CD3/28 monoclonal…”
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IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells by Santegoets, Saskia J A M, Turksma, Annelies W, Suhoski, Megan M, Stam, Anita G M, Albelda, Steve M, Hooijberg, Erik, Scheper, Rik J, van den Eertwegh, Alfons J M, Gerritsen, Winald R, Powell, Jr, Daniel J, June, Carl H, de Gruijl, Tanja D

“…Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor…”
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T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets by Alonso, Michael N, Wong, Michael T, Zhang, Angela L, Winer, Daniel, Suhoski, Megan M, Tolentino, Lorna L, Gaitan, Juliana, Davidson, Matthew G, Kung, Tiffany H, Galel, David M, Nadeau, Kari C, Kim, Jinah, Utz, Paul J, Söderström, Kalle, Engleman, Edgar G

“…Monocytes and T helper (T(H)) cells rapidly infiltrate inflamed tissues where monocytes differentiate into inflammatory dendritic cells (DCs) through undefined…”
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Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules by Suhoski, Megan M, Golovina, Tatiana N, Aqui, Nicole A, Tai, Victoria C, Varela-Rohena, Angel, Milone, Michael C, Carroll, Richard G, Riley, James L, June, Carl H

“…To facilitate the therapeutic application of antigen-presenting cells (APCs), we have developed a cell-based artificial APC (aAPC) system by engineering K562…”
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Cd14 SNPs regulate the innate immune response by Liu, Hong-Hsing, Hu, Yajing, Zheng, Ming, Suhoski, Megan M., Engleman, Edgar G., Dill, David L., Hudnall, Matt, Wang, Jianmei, Spolski, Rosanne, Leonard, Warren J., Peltz, Gary

“…► We discovered a novel genetic mechanism affecting murine CD14 translation and secretion. ► Variation in human CD14 transcript length also affects its…”
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Adoptive immunotherapy: good habits instilled at youth have long-term benefits by Paulos, Chrystal M., Suhoski, Megan M., Plesa, Gabriela, Jiang, Tianying, Basu, Samik, Golovina, Tatiana N., Jiang, Shuguang, Aqui, Nicole A., Powell, Daniel J., Levine, Bruce L., Carroll, Richard G., Riley, James L., June, Carl H.

“…Many recent advances in basic cell biology and immunology are a harbinger of progress in adoptive cell therapy (ACT) including (1) the finding that host…”
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First-in-Human Assessment of Feasibility and Safety of Multiplexed Genetic Engineering of Autologous T Cells Expressing NY-ESO -1 TCR and CRISPR/Cas9 Gene Edited to Eliminate Endogenous TCR and PD-1 (NYCE T cells) in Advanced Multiple Myeloma (MM) and Sarcoma by Stadtmauer, Edward A., Cohen, Adam D., Weber, Kristy, Lacey, Simon F, Gonzalez, Vanessa E., Melenhorst, J. Joseph, Fraietta, Joseph A, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Mangan, Patricia, Gaymon, Avery, Desjardins, Stephanie, Lancaster, Eric, Salas-Mckee, January, Suhoski, Megan M., Fesnak, Andrew, O'Rourke, Matthew, Lamontagne, Anne, Siegel, Don L., Young, Regina M, Chew, Anne, Nobles, Christopher L, Bushman, Frederic D., Chang, Howard Y., Satpathy, Ansuman T., Zhao, Yangbing, Hwang, Wei-Ting, Hexner, Elizabeth O., June, Carl H

“…Background: Autologous T cells genetically modified with a lentiviral vector to express affinity-enhanced T cell receptors (TCR) or chimeric antigen receptors…”
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