Search Results - "Suhm, Tamara"
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The basic machineries for mitochondrial protein quality control
Published in Mitochondrion (01-01-2020)“…Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper…”
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Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis
Published in Cell metabolism (05-06-2018)“…Cellular proteostasis is maintained via the coordinated synthesis, maintenance, and breakdown of proteins in the cytosol and organelles. While biogenesis of…”
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Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
Published in Nature communications (13-07-2021)“…The translocase of the outer mitochondrial membrane TOM constitutes the organellar entry gate for nearly all precursor proteins synthesized on cytosolic…”
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DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring
Published in Nature communications (20-06-2024)“…Mitochondria require an extensive proteome to maintain a variety of metabolic reactions, and changes in cellular demand depend on rapid adaptation of the…”
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Incorporation of reporter genes into mitochondrial DNA in budding yeast
Published in STAR protocols (17-06-2022)“…Many aspects of mitochondrial gene expression are still unknown, which can be attributed to limitations in molecular tools. Here, we present a protocol to…”
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Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System
Published in Cells (Basel, Switzerland) (17-10-2018)“…The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different…”
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A novel system to monitor mitochondrial translation in yeast
Published in Microbial cell (13-01-2018)“…The mitochondrial genome is responsible for the production of a handful of polypeptides that are core subunits of the membrane-bound oxidative phosphorylation…”
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Mitochondrial translation and cellular stress response
Published in Cell and tissue research (2017)“…Mitochondria are organelles critical for the functionality of eukaryotic cells. One of their most prominent functions is energy conversion, thereby producing…”
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Mitochondrial Substrate Availability and Its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signaling in Skeletal Muscle
Published in Diabetes (New York, N.Y.) (01-10-2013)“…The relationship between glucose and lipid metabolism has been of significant interest in understanding the pathogenesis of obesity-induced insulin resistance…”
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