Search Results - "Suh, Jaehong"

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity by Kim, Minji, Suh, Jaehong, Romano, Donna, Truong, Mimy H., Mullin, Kristina, Hooli, Basavaraj, Norton, David, Tesco, Giuseppina, Elliott, Kathy, Wagner, Steven L., Moir, Robert D., Becker, K. David, Tanzi, Rudolph E.

“…ADAM10, a member of a disintegrin and metalloprotease family, is an α-secretase capable of anti-amyloidogenic proteolysis of the amyloid precursor protein…”
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Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice by Lee, Jin Hwan, Won, Sun Mi, Suh, Jaehong, Son, Sun Joo, Moon, Gyeong Joon, Park, Ui-Jin, Gwag, Byoung Joo

“…The endoplasmic reticulum (ER) stress results from disrupted protein folding triggered by protein mutation or oxidation, reduced proteasome activity, and…”
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Analysis of brain region-specific mRNA synthesis and stability by utilizing adult mouse brain slice culture by Dzhala, Volodymyr, Fowler, Alan J., DiMarzio, Britt A., Staley, Kevin J., Suh, Jaehong

“…Utilization of live animals for mechanistic study is challenging yet pivotal to elucidate pathogenesis of neurological diseases. Here, we present a protocol…”
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Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: A potential modulator of Fas-mediated apoptosis by Lee, Jae Keun, Shin, Jin Hee, Suh, JaeHong, Choi, In Sun, Ryu, Keun Sil, Gwag, Byoung Joo

“…Abstract Cortical neurons deprived of serum undergo apoptosis that is sensitive to inhibitors of macromolecule synthesis. Proteomic analysis revealed…”
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Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing by Suh, Jaehong, Im, Doo Soon, Moon, Gyeong Joon, Ryu, Keun Sil, de Silva, Rohan, Choi, In Sun, Lees, Andrew J, Guénette, Suzanne Y, Tanzi, Rudolph E, Gwag, Byoung Joo

“…J. Neurochem. (2010) 114, 160-170. Alternative splicing of tau exon 10 influences microtubule assembly and stability during development and in pathological…”
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Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures by Suh, Jaehong, Lee, Young Ae, Gwag, Byoung Joo

“…Evidence has accumulated showing that pharmacological inhibition of proteasome activity can both induce and prevent neuronal apoptosis. We tested the…”
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Polychlorinated Biphenyl-Induced Apoptosis of Murine Spleen Cells Is Aryl Hydrocarbon Receptor Independent but Caspases Dependent by Jeon, Young Jin, Youk, Eun Soo, Lee, Sang Han, Suh, Jaehong, Na, Yong Joo, Kim, Hwan Mook

“…Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants and many of their toxic effects, including their immunotoxicities, are mediated by…”
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ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function by Suh, Jaehong, Choi, Se Hoon, Romano, Donna M., Gannon, Moira A., Lesinski, Andrea N., Kim, Doo Yeon, Tanzi, Rudolph E.

“…The generation of Aβ, the main component of senile plaques in Alzheimer’s disease (AD), is precluded by α-secretase cleavage within the Aβ domain of the…”
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Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls11This work was supported in part by funds from the National Institutes of Health Grant ES02520 and P42ES04911 and by a G7 Project Grant from the Ministry of Environment, Korea by Suh, Jaehong, Kang, Jong Soon, Yang, Kyu-Hwan, Kaminski, Norbert E

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Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription by Suh, Jaehong, Romano, Donna M., Nitschke, Larissa, Herrick, Scott P., DiMarzio, Britt A., Dzhala, Volodymyr, Bae, Jun-Seok, Oram, Mary K., Zheng, Yuejiao, Hooli, Basavaraj, Mullin, Kristina, Gennarino, Vincenzo A., Wasco, Wilma, Schmahmann, Jeremy D., Albers, Mark W., Zoghbi, Huda Y., Tanzi, Rudolph E.

“…Expansion of CAG trinucleotide repeats in ATXN1 causes spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease that impairs coordination and…”
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Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein by Kim, Byeong Mo, You, Mi-Hyeon, Chen, Chun-Hau, Suh, Jaehong, Tanzi, Rudolph E, Ho Lee, Tae

“…Extracellular deposition of amyloid-beta (Aβ) peptide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in the…”
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FE65 and FE65L1 amyloid precursor protein‐binding protein compound null mice display adult‐onset cataract and muscle weakness by Suh, Jaehong, Moncaster, Juliet A., Wang, Lirong, Hafeez, Imran, Herz, Joachim, Tanzi, Rudolph E., Goldstein, Lee E., Guénette, Suzanne Y.

“…ABSTRACT FE65 and FE65L1 are cytoplasmic adaptor proteins that bind a variety of proteins, including the amyloid precursor protein, and that mediate the…”
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Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain by Nensa, Fabian M., Neumann, Martin H.D., Schrötter, Andreas, Przyborski, Andre, Mastalski, Thomas, Susdalzew, Sergej, Looβe, Christina, Helling, Stefan, El Magraoui, Fouzi, Erdmann, Ralf, Meyer, Helmut E., Uszkoreit, Julian, Eisenacher, Martin, Suh, Jaehong, Guénette, Suzanne Y., Röhner, Nelli, Kögel, Donat, Theiss, Carsten, Marcus, Katrin, Müller, Thorsten

“…FE65 is a cytosolic adapter protein and an important binding partner of amyloid precursor protein. Dependent on Thr668 phosphorylation in amyloid precursor…”
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ADAM10 Missense Mutations Potentiate [beta]-Amyloid Accumulation by Impairing Prodomain Chaperone Function by Suh, Jaehong, Choi, Se Hoon, Romano, Donna M, Gannon, Moira A, Lesinski, Andrea N, Kim, Doo Yeon, Tanzi, Rudolph E

“…The generation of Aβ, the main component of senile plaques in Alzheimer's disease (AD), is precluded by [alpha]-secretase cleavage within the Aβ domain of the…”
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FE65 proteins regulate NMDA receptor activation‐induced amyloid precursor protein processing by Suh, Jaehong, Lyckman, Alvin, Wang, Lirong, Eckman, Elizabeth A., Guénette, Suzanne Y.

“…J. Neurochem. (2011) 119, 377–388. Amyloid precursor protein (APP) family members and their proteolytic products are implicated in normal nervous system…”
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Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di- ortho-substituted polychlorinated biphenyls by Suh, Jaehong, Kang, Jong Soon, Yang, Kyu-Hwan, Kaminski, Norbert E

“…Halogenated aromatic hydrocarbons (HAHs) are ubiquitous environment contaminants that produce many of their toxic effects by binding to the aryl hydrocarbon…”
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Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity by Kim, Minji, Suh, Jaehong, Romano, Donna, Truong, Mimy H, Mullin, Kristina, Hooli, Basavaraj, Norton, David, Tesco, Giuseppina, Elliott, Kathy, Wagner, Steven L, Moir, Robert D, Becker, K David, Tanzi, Rudolph E

“…ADAM10, a member of a disintegrin and metalloprotease family, is an alpha-secretase capable of anti-amyloidogenic proteolysis of the amyloid precursor protein…”
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Aryl Hydrocarbon Receptor-Dependent Inhibition of AP-1 Activity by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Activated B Cells by Suh, Jaehong, Jeon, Young Jin, Kim, Hwan Mook, Kang, Jong Soon, Kaminski, Norbert E., Yang, Kyu-Hwan

“…B cells have been identified as sensitive cellular targets responsible for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated suppression of humoral immunity…”
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Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain by Nensa, Fabian M, Neumann, Martin H D, Schrötter, Andreas, Przyborski, Andre, Mastalski, Thomas, Susdalzew, Sergej, Looβe, Christina, Helling, Stefan, El Magraoui, Fouzi, Erdmann, Ralf, Meyer, Helmut E, Uszkoreit, Julian, Eisenacher, Martin, Suh, Jaehong, Guénette, Suzanne Y, Röhner, Nelli, Kögel, Donat, Theiss, Carsten, Marcus, Katrin, Müller, Thorsten

“…FE65 is a cytosolic adapter protein and an important binding partner of amyloid precursor protein. Dependent on Thr668 phosphorylation in amyloid precursor…”
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On-line machinery health diagnosis and prognosis for predictive maintenance and quality assurance of equipment functioning by Suh, Jaehong

“…Machinery health diagnosis and prognosis based on process models and/or process parameters is an important function in automated manufacturing set-ups and…”
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