Search Results - "Suh, Hyung C"

Using Targeted Transcriptome and Machine Learning of Pre- and Post-Transplant Bone Marrow Samples to Predict Acute Graft-versus-Host Disease and Overall Survival after Allogeneic Stem Cell Transplantation by Rowley, Scott D, Gunning, Thomas S, Pelliccia, Michael, Della Pia, Alexandra, Lee, Albert, Behrmann, James, Bangolo, Ayrton, Jandir, Parul, Zhang, Hong, Kaur, Sukhdeep, Suh, Hyung C, Donato, Michele, Albitar, Maher, Ip, Andrew

“…Acute graft-versus-host disease (aGvHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). We…”
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LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes by Suh, Hyung C., Benoukraf, Touati, Shyamsunder, Pavithra, Yin, Tong, Cao, Qi, Said, Jonathan, Lee, Stephen, Lim, Ricky, Yang, Henry, Salotti, Jacqueline, Johnson, Peter F., Madan, Vikas, Koeffler, H. Phillip

“…C/EBPε is a critical transcriptional factor for granulocyte differentiation and function. Individuals with germline mutations of C/EBPε fail to develop normal…”
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682 Trial in progress: phase 1 trial of TSC-100 and TSC-101, engineered T-cell therapies targeting minor histocompatibility antigens to eliminate residual disease after hematopoietic cell transplantation by Malki, Monzr Al, Keyzner, Alla, Suh, Hyung C, Matin, Aasiya, Buonomo, Erica, Wang, Yun, Abelowitz, Nina, Murray, Jim, MacBeath, Gavin, Barton, Debora, Chattopadhyay, Shrikanta, Reshef, Ran

“…BackgroundEngineered T cell therapies such as CAR-T cell therapies have transformed the treatment of B-cell but not non-B cell hematologic malignancies…”
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Trial in Progress: An Open-Label, Multi-Center Phase 2 Study to Assess the Safety and Efficacy of Burixafor (GPC-100) and Propranolol with and without G-CSF for the Mobilization of Stem Cells in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplant by Caculitan, Nina, Cardarelli, Josephine M., Khouri, Jack, Suh, Hyung C, Ramanathan, Muthalagu, Woolfrey, Ann

“…Background and Significance: Poor stem cell mobilization with failure to produce the target cell dose of ≥2x10 6 CD34 cells/kg required for autologous stem…”
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Graft-Versus-Host Disease (GvHD) Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation (haplo-PBSCT) Using Abatacept in Combination with Post-Transplant Cyclophosphamide (PTCy) by Kaur, Sukhdeep, Gelman, Simon, Rowley, Scott, Baker, Eliana, Baker, Melissa, Suh, Hyung C, Cho, Christina, Donato, Michele L.

“…Background: Multiple studies demonstrated the efficacy of PTCy in achieving successful multiple-HLA-antigen mismatched (haploidentical) donor transplantation…”
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Comparison of Fludarabine/Cyclophosphamide Vs Bendamustine As Lymphodepleting Regimen for CAR-T: A Safety and Efficacy Analysis in Patients with Relapsed/ Refractory Multiple Myeloma by Gill, Sarvarinder Kaur, Biran, Noa, Phull, Pooja, Kaur, Sukhdeep, Suh, Hyung C, Cho, Christina, Donato, Michele L., Rowley, Scott D, Vesole, David H., Siegel, David S., Parmar, Harsh

“…Background Two commercially available anti-BCMA chimeric antigen receptor T-cell therapies (CAR-T) are approved by FDA for use in patients with relapsed…”
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Dynamic Changes in Pre- and 3 Months Post-Transplant NGS MRD Status May Predict the Allogeneic Stem Cell Transplant Outcome of Patients with AML by Suh, Hyung C, Einstein, Amy, Georgantzis, Addi, McKiernan, Phyllis, Baker, Melissa, Boonstra, Michele S, Kaur, Sukhdeep, Cho, Christina, Rowley, Scott D, Donato, Michele L.

“…Introduction: To deal with the high propensity for relapse and substantial genetic heterogeneity of AML, monitoring measurable residual disease (MRD) has…”
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Comparison of Non-Myeloablative Conditioning Regimens Flu/Bu2, Flu/Mel 100 and Flu/TBI in Patients with AML and MDS by McKiernan, Phyllis, Gelman, Simon, Rowley, Scott D, Kaur, Sukhdeep, Cho, Christina, Suh, Hyung C, Boonstra, Michele S, Georgantzis, Addi, Baker, Melissa, Einstein, Amy, Donato, Michele L.

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment modality for patients with myelodysplastic syndrome (MDS) or…”
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Using Targeted Transcriptome and Machine Learning of Pre- and Post-Transplant Bone Marrow Samples to Predict Acute Gvhd (aGVHD) and Overall Survival after Allogeneic HSC Transplantation by Albitar, Maher, Zhang, Hong, Pecora, Andrew L., Ip, Andrew, Goy, Andre H., Antzoulatos, Spiraggelos, Ma, Wanlong, Kaur, Sukhdeep, Suh, Hyung C., Donato, Michele L., Rowley, Scott D.

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Effect of Daratumumab on Stem Cell Mobilization and Engraftment Kinetics Post Autologous Stem Cell Transplantation in Patients with Newly Diagnosed Multiple Myeloma by Oza, Samir, Slotky, Ronit, Vissa, Pranay, Phull, Pooja, Kaur, Sukhdeep, Suh, Hyung C., Donato, Michele L., Rowley, Scott D., Biran, Noa, Vesole, David H., Siegel, David, Parmar, Harsh

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A phase 1 trial of TSC-100 and TSC-101, engineered T cell therapies that target minor histocompatibility antigens to eliminate residual disease after hematopoietic cell transplantation by Al Malki, Monzr M., Keyzner, Alla, Suh, Hyung C., Popat, Uday R., Gill, Saar, Chen, Yi-Bin Albert, Solh, Melhem M., Gowda, Lohith, Buonomo, Erica, Wang, Yun, Murray, Jim, MacBeath, Gavin, Barton, Debora, Chattopadhyay, Shrikanta, Reshef, Ran

“…TPS2678 Background: Engineered T cell therapies such as CAR-T cell therapies have transformed the treatment of B-cell but not non-B cell hematologic…”
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Trem-Cel, a CRISPR/Cas9 Gene-Edited Allograft Lacking CD33, Shows Rapid Primary Engraftment with CD33-Negative Hematopoiesis in Patients with High-Risk Acute Myeloid Leukemia (AML) and Avoids Hematopoietic Toxicity during Gemtuzumab Ozogamicin (GO) Maintenance Post-Hematopoietic Cell Transplant (HCT) by DiPersio, John, Cooper, Brenda W, Suh, Hyung C, Koura, Divya, Bernard, Lea, Shah, Nirali N., Walter, Roland B., Perales, Miguel-Angel, Mapara, Markus, Tamari, Roni, Loken, Michael R., Breitschwerdt, Kyle, Nath, Sritama, Raffel, Glen D, Koehne, Guenther

“…Background: Allogeneic HCT is the standard of care for eligible patients with AML harboring high-risk features such as adverse-risk cytogenetics or measurable…”
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Fluoroquinolone-Resistant Enterobacteriaceae Prevalence for Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation (aHSCT) in the Treatment of Multiple Myeloma (MM) by Titova, Elizabeth, Rowley, Scott, Kreiswirth, Barry, Baker, Melissa, Baker, Eliana, Cho, Christina, Renteria, Anne S., Ali, Alaa, Munshi, Pashna N., Kaur, Sukhdeep, Donato, Michele L., Dash, Chiranjeev, Suh, Hyung C, Yen, Kelly K., Terlecky, Austin J.

“…Background: Fluoroquinolones (FQL) are commonly used in antimicrobial prophylaxis in immunocompromised cancer patients (pts) during prolonged neutropenia. A…”
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Assessment of Serology after Sars-Cov-2 Vaccine in Allogeneic HCT Recipients by Baker, Melissa, Cortes, Maria, Ahn, Jaeil, Donato, Michele L., Kaur, Sukhdeep, Suh, Hyung C., Morawski, Alison, McKiernan, Phyllis, Einstein, Amy, Boonstra, Michele, Rowley, Scott D.

“…Introduction: Randomized trials demonstrated ~95% efficacy of SARS-CoV-2 spike messenger RNA (mRNA) vaccines. Patients (pts) after allogeneic hematopoietic…”
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Trial in Progress: A Phase 1 Umbrella Study of TCR-Engineered T Cells That Target HA-1 (TSC-100) and HA-2 (TSC-101) to Treat Residual Leukemia after Hematopoietic Cell Transplantation by Reshef, Ran, Suh, Hyung C., Al Malki, Monzr M., Matin, Aasiya, Kothari, Ashish S, Bell, Allison, Boudot, Antoine J, Wang, Yun, Abelowitz, Nina, Murray, James, Macbeath, Gavin, Barton, Debora, Chattopadhyay, Shrikanta

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Comparison of Bendamustine Versus Fludarabine/ Cyclophosphamide Lymphodepletion in Adult Patients Receiving CD19 CAR-T Cell Therapy by Landego, Ivan, Nemirovsky, David, Devlin, Sean M., Wills, Beatriz, Parascondola, Allison, Saldia, Amethyst, Dahi, Parastoo B., Alarcon Tomas, Ana, Ip, Andrew, Suh, Hyung C, Leslie, Lori A., Nath, Karthik, Giralt, Sergio A., Lin, Richard J., Palomba, Maria Lia, Salles, Gilles, Shah, Gunjan L., Shouval, Roni, Perales, Miguel-Angel, Scordo, Michael

“…INTRODUCTION: Lymphodepleting chemotherapy (LDC) prior to CAR-T infusion is required for more effective expansion and persistence of infused T cells. Most…”
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Bone Marrow-Based Biomarkers for Predicting aGVHD Using Targeted RNA Next Generation Sequencing and Machine Learning by Albitar, Maher, Zhang, Hong, Pecora, Andrew L., Ip, Andrew, Goy, Andre H., Antzoulatos, Spiraggelos, De Dios, Ivan, Ma, Wanlong, Kaur, Sukhdeep, Suh, Hyung C., Donato, Michele L., Rowley, Scott D.

“…Introduction: Acute graft-vs.-host disease (aGVHD) remains a major diagnostic and clinical problem in patients after allogenic hematopoietic stem cell…”
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Reliability of Liquid Biopsy and Next Generation Sequencing in Monitoring Residual Disease Post-Hematopoietic Stem Cell Transplant by Albitar, Maher, Zhang, Hong, Pecora, Andrew L., Ip, Andrew, Goy, Andre H., Estella, Jeffrey Justin, De Dios, Ivan, Ma, Wanlong, Kaur, Sukhdeep, Suh, Hyung C., Donato, Michele L., Rowley, Scott D.

“…Introduction: Using next generation sequencing (NGS) in monitoring residual disease in patients with myeloid neoplasms is complicated by the significant…”
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Bioengineered Autologous Dendritic Cells Enhance CAR T Cell Cytotoxicity By Providing Cytokine Stimulation and Intratumoral Dendritic Cells by Suh, Hyung C, Pohl, Katherine A., Termini, Christina, Kan, Jenny, Timmerman, John M., Slamon, Dennis J., Chute, John P

“…▪ Background: The combination of antigen recognition, costimulatory ligands, and dendritic cells (DC)-derived cytokines (IL-12 or type I IFNs) stimulate T…”
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Trial in Progress: A First-in-Human Phase 1/2 Study of Hematopoietic Stem Cell Transplantation (HCT) with VOR33 (CD33-Deleted Allograft) Followed By Treatment with Gemtuzumab Ozogamicin (GO) in Patients with CD33+ Acute Myeloid Leukemia (AML) Who Are at High-Risk of Post-HCT Relapse by Cooper, Brenda W., Suh, Hyung C., Koura, Divya, Koehne, Guenther, Cho, Christina, Bambace, Nadia M., Bernard, Léa, Shah, Nirali N., Walter, Roland B., DiPersio, John F., Nath, Sritama, Lee-Sundlov, Melissa M., Lacy, Ali, Stanizzi, Darren, Kuhn, Karen, Whangbo, Jennifer S., Slapak, Christopher, Raffel, Glen D.

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