Search Results - "Sugrue, M F"

New Approaches to Antiglaucoma Therapy by Sugrue, Michael F

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The preclinical pharmacology of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor by Sugrue, M F

“…Dorzolamide hydrochloride (S,S-5,6-dihydro-4H-4-ethylamino-6-methylthieno [2,3-b]thiopyran-2-sulfonamide-7,7-dioxide HCl; MK-507; L-671,152) is a…”
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Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors by Sugrue, Michael F.

“…There was a time gap of over 40 years between the demonstrated oral effectiveness of acetazolamide in lowering the intraocular pressure (IOP) of glaucoma…”
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Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma by Baldwin, John J, Ponticello, Gerald S, Anderson, Paul S, Christy, Marcia E, Murcko, Mark A, Randall, William C, Schwam, Harvey, Sugrue, Michael F, Gautheron, Pierre

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A comparison of L-671,152 and MK-927, two topically effective ocular hypotensive carbonic anhydrase inhibitors, in experimental animals by Sugrue, M F, Mallorga, P, Schwam, H, Baldwin, J J, Ponticello, G S

“…L-671,152 is a water-soluble, carbonic anhydrase inhibitor structurally similar to MK-927, a carbonic anhydrase inhibitor that, on topical administration,…”
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The pharmacology of antiglaucoma drugs by Sugrue, M F

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Neuropharmacology of drugs affecting food intake by Sugrue, M F

“…The importance of the central monoamines NE, DA and 5-HT in ingestive behavior has inevitably resulted in considerable effort being expended in attempting to…”
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Synthetic atrial natriuretic factor lowers rabbit intraocular pressure by Sugrue, M F, Viader, M P

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L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals by Sugrue, M.F., Gautheron, P., Mallorga, P., Nolan, T.E., Graham, S.L., Schwam, H., Shepard, K.L., Smith, R.L.

“…1 L‐662,583 was a potent inhibitor in vitro of purified, human erythrocyte carbonic anhydrase II, possessing an IC50 of 0.7 nm. The IC50 values for MK‐927,…”
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On the pharmacology of L-645,151: a topically effective ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Schmitt, C, Viader, M P, Conquet, P, Smith, R L, Share, N N, Stone, C A

“…L-645,151 [(2-sulfamoyl-6-benzothiazolyl)-2,2-dimethylpropionate] is the O-pivaloyl ester of L-643,799 (6-hydroxybenzothiazole-2-sulfonamide), topically…”
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The effect of cyclooxygenase inhibition on the ocular hypotensive action of topical carbonic anhydrase inhibitors in rabbits by Sugrue, M F, O'Neill-Davis, L

“…Experiments were undertaken in normal albino rabbits to determine if cyclooxygenase inhibition by nonsteroidal anti-inflammatory drugs modified the ocular…”
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Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase by Scholz, Thomas H, Sondey, John M, Randall, William C, Schwam, Harvey, Thompson, Wayne J, Mallorga, Pierre J, Sugrue, Michael F, Graham, Samuel L

“…A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic…”
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Muscarinic receptors of the albino rabbit ciliary process by Mallorga, P, Babilon, R W, Buisson, S, Sugrue, M F

“…Muscarinic receptor binding sites were identified in membranes prepared from albino rabbit ciliary processes, using the muscarinic antagonist…”
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3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors by Hunt, Cecilia A, Mallorga, Pierre J, Michelson, Stuart R, Schwam, Harvey, Sondey, John M, Smith, Robert L, Sugrue, Michael F, Shepard, Kenneth L

“…3-Aminoalkyl derivatives of thieno[2,3-b][1,4]thiazine-6-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. The compounds…”
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The ability of salbutamol and theophylline to suppress immediate allergic conjunctivitis in the guinea pig by GAUTHERON, P, SUGRUE, M. F

“…Topically administered salbutamol was extremely effective in suppressing immediate allergic conjunctivitis in the guinea pig; a dose as low as 0.1% elicited…”
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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex…”
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Effect of depletion of rat brain 5-hydroxytryptamine on morphine-induced antinociception by Sugrue, M F

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L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity by Sugrue, MF, Gautheron, P, Grove, J, Mallorga, P, Viader, MP, Baldwin, JJ, Ponticello, GS, Varga, SL

“…L-653,328 is the acetate ester of L-652,698 ((S)-3-tert-butylamino-1-[4-[2(hydroxy)ethyl]phenoxy]2-propanol). The penetration of L-652,698 into the albino…”
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MK-927: a topically active ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Grove, J, Mallorga, P, Viader, M P, Schwam, H, Baldwin, J J, Christy, M E, Ponticello, G S

“…MK-927 (dl-5,6-dihydro-4-(2-methylpropylamino)-4H-thieno(2,3b)thiopyra n-2-sulfonamide-7,7-dioxide hydrochloride) is a water soluble, carbonic anhydrase…”
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Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys by Tigges, M, Iuvone, P M, Fernandes, A, Sugrue, M F, Mallorga, P J, Laties, A M, Stone, R A

“…To study a potential role for muscarinic receptors in the inhibition of deprivation-induced excessive axial elongation and myopia in a monkey model. The right…”
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