Search Results - "Sugiyama, Y."

Transporter-Mediated Drug-Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies by Yoshida, K, Maeda, K, Sugiyama, Y

“…Transporter‐mediated drug–drug interactions (DDIs) are among the most important of the clinically relevant pharmacokinetic DDIs. We investigated the validity…”
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Endogenous Probes for Drug Transporters: Balancing Vision With Reality by Rodrigues, AD, Taskar, KS, Kusuhara, H, Sugiyama, Y

“…Various endogenous probes have been identified for a number of hepatic and renal drug transporters and available clinical data indicate that they could be…”
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International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms by Giacomini, K M, Balimane, P V, Cho, S K, Eadon, M, Edeki, T, Hillgren, K M, Huang, S-M, Sugiyama, Y, Weitz, D, Wen, Y, Xia, C Q, Yee, S W, Zimdahl, H, Niemi, M

“…This Commentary focuses on genetic polymorphisms in membrane transporters. We present two polymorphisms for which there is a compelling body of literature…”
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Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study by Maeda, K, Ikeda, Y, Fujita, T, Yoshida, K, Azuma, Y, Haruyama, Y, Yamane, N, Kumagai, Y, Sugiyama, Y

“…Clearance of atorvastatin occurs through hepatic uptake by organic anion transporting polypeptides (OATPs) and subsequent metabolism by cytochrome P450 (CYP)…”
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Structural investigation of composite wind turbine blade considering various load cases and fatigue life by Kong, C., Bang, J., Sugiyama, Y.

“…This study proposes a structural design for developing a medium scale composite wind turbine blade made of E-glass/epoxy for a 750 kW class horizontal axis…”
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Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver by Chu, X, Korzekwa, K, Elsby, R, Fenner, K, Galetin, A, Lai, Y, Matsson, P, Moss, A, Nagar, S, Rosania, G R, Bai, J P F, Polli, J W, Sugiyama, Y, Brouwer, K L R

“…Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution…”
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Ethnic Variability in the Plasma Exposures of OATP1B1 Substrates Such as HMG-CoA Reductase Inhibitors: A Kinetic Consideration of Its Mechanism by Tomita, Y, Maeda, K, Sugiyama, Y

“…Because the plasma exposure levels of rosuvastatin in Asians are generally twice those in Caucasians, the starting dose for Asians in the United States is set…”
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Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects by Kusuhara, H, Ito, S, Kumagai, Y, Jiang, M, Shiroshita, T, Moriyama, Y, Inoue, K, Yuasa, H, Sugiyama, Y

“…A microdose study of metformin was conducted to investigate the predictability of drug–drug interactions at the therapeutic dose (ThD). Healthy subjects…”
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Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method by Yoshikado, T, Yoshida, K, Kotani, N, Nakada, T, Asaumi, R, Toshimoto, K, Maeda, K, Kusuhara, H, Sugiyama, Y

“…This study aimed to construct a widely applicable method for quantitative analyses of drug–drug interactions (DDIs) caused by the inhibition of hepatic organic…”
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N-Methylnicotinamide Is an Endogenous Probe for Evaluation of Drug-Drug Interactions Involving Multidrug and Toxin Extrusions (MATE1 and MATE2-K) by Ito, S, Kusuhara, H, Kumagai, Y, Moriyama, Y, Inoue, K, Kondo, T, Nakayama, H, Horita, S, Tanabe, K, Yuasa, H, Sugiyama, Y

“…Multidrug and toxin extrusion 1 (MATE1) and MATE2‐K are H+/organic cation exchangers mediating the efflux of cationic drugs into the urine…”
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Comparison of blast mitigation performance between water layers and water droplets by Tamba, T., Sugiyama, Y., Ohtani, K., Wakabayashi, K.

“…An experimental investigation was conducted to compare the blast mitigation performances of water layers, whose mass ratios to an explosive were m W / m E =…”
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Bias polarity dependent data retention of resistive random access memory consisting of binary transition metal oxide by Kinoshita, K., Tamura, T., Aoki, M., Sugiyama, Y., Tanaka, H.

“…The authors investigated the data retention properties of Ni O y resistors exposed to sputtered particles and found that they depended on the bias polarity…”
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Numerical investigation of the interaction between a shock wave and a particle cloud curtain using a CFD–DEM model by Sugiyama, Y., Ando, H., Shimura, K., Matsuo, A.

“…A two-dimensional numerical simulation of the interaction between a shock wave and a particle cloud curtain (PCC) in a shock tube was conducted to develop the…”
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Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract by Kurosaki, F, Uchibori, R, Mato, N, Sehara, Y, Saga, Y, Urabe, M, Mizukami, H, Sugiyama, Y, Kume, A

“…An efficient adeno-associated virus (AAV) vector was constructed for the treatment of respiratory diseases. AAV serotypes, promoters and routes of…”
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Transporters as a determinant of drug clearance and tissue distribution by Shitara, Yoshihisa, Horie, Toshiharu, Sugiyama, Yuichi

“…Transporters play an important role in the processes of drug absorption, distribution and excretion. In this review, we have focused on the involvement of…”
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Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis by Tsuji, S, Midorikawa, Y, Takahashi, T, Yagi, K, Takayama, T, Yoshida, K, Sugiyama, Y, Aburatani, H

“…Background: Molecular characterisation using gene-expression profiling will undoubtedly improve the prediction of treatment responses, and ultimately, the…”
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Numerical study on the effect of the initiation process of cylindrical high explosives on the blast-wave behavior by Sugiyama, Y., Homae, T., Matsumura, T., Wakabayashi, K.

“…We conducted a series of numerical simulations to understand the effect of the initiation process of cylindrical high explosives on the blast-wave behavior and…”
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Blackbody-like infrared radiation in stacked graphene P–N junction diode by Murakami, N., Sugiyama, Y., Ohno, Y., Nagase, M.

“…Abstract The electrical and optical properties of a stacked graphene p–n junction were investigated. N-type and p-type graphene films epitaxially grown on a…”
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Elasto-plastic modelling of shear failure of the plate boundary decollement zone by Sugiyama, Y, Tachibana, S, Sakaguchi, H, Iizuka, A

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Prediction of Fluoroquinolone-Induced Elevation in Serum Creatinine Levels: A Case of Drug-Endogenous Substance Interaction Involving the Inhibition of Renal Secretion by Imamura, Y, Murayama, N, Okudaira, N, Kurihara, A, Okazaki, O, Izumi, T, Inoue, K, Yuasa, H, Kusuhara, H, Sugiyama, Y

“…The aim of this study was to examine the mechanism underlying the elevation in serum creatinine levels caused by a novel des‐fluoro(6)‐quinolone antibacterial…”
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