Search Results - "Sugiyama, G."

Estrogen Inhibits LDL (Low-Density Lipoprotein) Transcytosis by Human Coronary Artery Endothelial Cells via GPER (G-Protein–Coupled Estrogen Receptor) and SR-BI (Scavenger Receptor Class B Type 1) by Ghaffari, Siavash, Naderi Nabi, Farnoosh, Sugiyama, Michael G, Lee, Warren L

“…OBJECTIVE—The atheroprotective effects of estrogen are independent of circulating lipid levels. Whether estrogen regulates transcytosis of LDL (low-density…”
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Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation by Ramírez, Cristina M, Zhang, Xinbo, Bandyopadhyay, Chirosree, Rotllan, Noemi, Sugiyama, Michael G, Aryal, Binod, Liu, Xinran, He, Shun, Kraehling, Jan R, Ulrich, Victoria, Lin, Chin Sheng, Velazquez, Heino, Lasunción, Miguel A, Li, Guangxin, Suárez, Yajaira, Tellides, George, Swirski, Filip K, Lee, Warren L, Schwartz, Martin A, Sessa, William C, Fernández-Hernando, Carlos

“…BACKGROUND:Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous…”
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Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling by Sugiyama, Michael G, Fairn, Gregory D, Antonescu, Costin N

“…The serine/threonine kinase Akt is a master regulator of many diverse cellular functions, including survival, growth, metabolism, migration, and…”
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Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling by Sugiyama, Michael G., Brown, Aidan I., Vega-Lugo, Jesus, Borges, Jazlyn P., Scott, Andrew M., Jaqaman, Khuloud, Fairn, Gregory D., Antonescu, Costin N.

“…The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization,…”
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Obesity and surgical complications of pancreaticoduodenectomy: An observation study utilizing ACS NSQIP by Chang, E.H., Sugiyama, G., Smith, M.C., Nealon, W.H., Gross, D.J., Apterbach, G., Coppa, G.F., Alfonso, A.E., Chung, P.J.

“…An estimated 38% of US adults are obese. Obesity is associated with socioeconomic disparities and increased rates of comorbidities, and is a known risk factor…”
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The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine by Praslickova, Dana, Torchia, Enrique C, Sugiyama, Michael G, Magrane, Elijah J, Zwicker, Brittnee L, Kolodzieyski, Lev, Agellon, Luis B

“…The ileal lipid binding protein (ilbp) is a cytoplasmic protein that binds bile acids with high affinity. However evidence demonstrating the role of this…”
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Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome by Sugiyama, Michael G, Mintsopoulos, Victoria, Raheel, Hira, Goldenberg, Neil M, Batt, Jane E, Brochard, Laurent, Kuebler, Wolfgang M, Leong-Poi, Howard, Karshafian, Raffi, Lee, Warren L

“…To the Editor: Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by lung microvascular leakage leading to pulmonary edema and…”
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Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation by Jones, Sylwia, King, Peter J., Antonescu, Costin N., Sugiyama, Michael G., Bhamra, Amandeep, Surinova, Silvia, Angelopoulos, Nicos, Kragh, Michael, Pedersen, Mikkel W., Hartley, John A., Futter, Clare E., Hochhauser, Daniel

“…Antibody combinations targeting cell surface receptors are a new modality of cancer therapy. The trafficking and signalling mechanisms regulated by such…”
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It’s not just an ileus: disparities associated with ileus following ventral hernia repair by Lee, M. J., Sugiyama, G., Alfonso, A., Coppa, G. F., Chung, P. J.

“…Purpose We sought to identify risk factors associated with postoperative ileus following ventral hernia repair. Methods Utilizing the Nationwide Inpatient…”
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Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics by Walker, Timothy J, Reyes-Alvarez, Eduardo, Hyndman, Brandy D, Sugiyama, Michael G, Oliveira, Larissa C B, Rekab, Aisha N, Crupi, Mathieu J F, Cabral-Dias, Rebecca, Guo, Qianjin, Dahia, Patricia L M, Richardson, Douglas S, Antonescu, Costin N, Mulligan, Lois M

“…Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that…”
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The Tie2-agonist Vasculotide rescues mice from influenza virus infection by Sugiyama, Michael G., Armstrong, Susan M., Wang, Changsen, Hwang, David, Leong-Poi, Howard, Advani, Andrew, Advani, Suzanne, Zhang, Haibo, Szaszi, Katalin, Tabuchi, Arata, Kuebler, Wolfgang M., Van Slyke, Paul, Dumont, Dan J., Lee, Warren L.

“…Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral…”
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Effect of NH3 gas on the electrical conductivity of polyaniline blend films by MATSUEUCHI, M, IO, J, SUGIYAMA, G, SAKAI, Y

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Predicting 30-day postoperative mortality for emergent anterior abdominal wall hernia repairs using the American College of Surgeons National Surgical Quality Improvement Program database by Chung, P. J., Lee, J. S., Tam, S., Schwartzman, A., Bernstein, M. O., Dresner, L., Alfonso, A., Sugiyama, G.

“…Purpose Anterior abdominal wall hernias are among the most commonly encountered surgical disease. We sought to identify risk factors that are associated with…”
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Outcomes in video-assisted thoracoscopic surgery lobectomies: challenging preconceived notions by Gross, D.J., Chang, E.H., Rosen, P.L., Roudnitsky, V., Muthusamy, M., Sugiyama, G., Chung, P.J.

“…Most thoracic surgical procedures in the United States are being performed by general surgeons (GSs) without any advanced training. With the recent approval of…”
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How Sick are Dialysis Patients Undergoing Cholecystectomy? Analysis of 93,703 Patients From the American College of Surgeons National Surgical Quality Improvement Program Database by Tam, S, Sugiyama, G

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30-Day Postoperative Mortality Risk Score for Coronary Artery Bypass Graft Surgery Using the American College of Surgeons National Surgical Quality Improvement Database by Chung, P.J, Tam, S, Burack, J, Sugiyama, G

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Is it time to rethink our management of dialysis patients undergoing elective ventral hernia repair? Analysis of the ACS NSQIP database by Tam, S. F., Au, J. T., Chung, P. J., Duncan, A., Alfonso, A. E., Sugiyama, G.

“…Purpose The number of patients on chronic dialysis is steadily increasing each year. There is little data that describes the outcomes in dialysis patients…”
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Colorectal Cancer Presents at an Earlier Stage but with Greater Complications in Patients with Poor Access to Health Care: Experience at an Urban Institution by Parks, J, Doukas, D, Au, J.T, Schwartzman, A, Sugiyama, G

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Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease by Sugiyama, Michael G., Cui, Haotian, Redka, Dar’ya S., Karimzadeh, Mehran, Rujas, Edurne, Maan, Hassaan, Hayat, Sikander, Cheung, Kyle, Misra, Rahul, McPhee, Joseph B., Viirre, Russell D., Haller, Andrew, Botelho, Roberto J., Karshafian, Raffi, Sabatinos, Sarah A., Fairn, Gregory D., Madani Tonekaboni, Seyed Ali, Windemuth, Andreas, Julien, Jean-Philippe, Shahani, Vijay, MacKinnon, Stephen S., Wang, Bo, Antonescu, Costin N.

“…The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by…”
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Clinical trial: comparison of alendronate and alfacalcidol in glucocorticoid‐associated osteoporosis in patients with ulcerative colitis by KITAZAKI, S., MITSUYAMA, K., MASUDA, J., HARADA, K., YAMASAKI, H., KUWAKI, K., TAKEDATSU, H., SUGIYAMA, G., TSURUTA, O., SATA, M.

“…Summary Background  Bone loss is often observed in patients with ulcerative colitis, particularly if they require glucocorticoids. Aim  To determine whether…”
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