Search Results - "Sugiyama, Eiko"

Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice by Nakajima, Takero, Yang, Yang, Lu, Yu, Kamijo, Yuji, Yamada, Yosuke, Nakamura, Kozo, Koyama, Masahiro, Yamaguchi, Shohei, Sugiyama, Eiko, Tanaka, Naoki, Aoyama, Toshifumi

“…Insufficient intake of polyunsaturated fatty acids (PUFA) causes fatty liver. The mechanism responsible is primarily related to increased lipogenesis and…”
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Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis by Yang, Yang, Feng, Yuyao, Zhang, Xiaowei, Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Kamijo, Yuji, Aoyama, Toshifumi

“…Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the first reaction in the mitochondrial fatty acid β-oxidation pathway. VLCAD deficiency is associated…”
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Epidemiology of anorexia nervosa in Japanese adolescents by Hotta, Mari, Horikawa, Reiko, Mabe, Hiroyo, Yokoyama, Shin, Sugiyama, Eiko, Yonekawa, Tadato, Nakazato, Masamitsu, Okamoto, Yuri, Ohara, Chisato, Ogawa, Yoshihiro

“…No epidemiologic survey examining eating disorders in Japan has been done at a national level since 1992. The prevalence of anorexia nervosa, as assessed by…”
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Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice by Kanbe, Hiroki, Kamijo, Yuji, Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Wang, Lixuan, Fang, Zhong-Ze, Hara, Atsushi, Gonzalez, Frank J., Aoyama, Toshifumi

“…Epidemiological studies demonstrate a possible relationship between chronic ethanol drinking and thrombotic diseases, such as myocardial infarction and stroke…”
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Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha by Sugiyama, Eiko, Ishikawa, Yasuko, Li, Yufeng, Kagai, Tomoko, Nobayashi, Misaki, Tanaka, Naoki, Kamijo, Yuji, Yokoyama, Shin, Hara, Atsushi, Aoyama, Toshifumi

“…Eicosapentaenoic acid (EPA) is known to lower plasma cholesterol level and triglycerides, but its precise molecular mechanisms have not been reported. The…”
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Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress by Sheng, Xiaona, Nakajima, Takero, Wang, Lixuan, Zhang, Xiaowei, Kamijo, Yuji, Takahashi, Kyoko, Tanaka, Naoki, Sugiyama, Eiko, Kyogashima, Mamoru, Aoyama, Toshifumi, Hara, Atsushi

“…Serum sulfatides are the major glycosphingolipids in lipoproteins. Although serum sulfatides are mainly synthesized and secreted by the liver, they are…”
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Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency by Wakabayashi, Masato, Kamijo, Yuji, Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Yangyang, Tian, Kimura, Takefumi, Aoyama, Toshifumi

“…To examine fatty acid accumulation and its toxic effects in cells, we analyzed skin fibroblasts from six patients with mitochondrial trifunctional protein…”
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Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice by Tanaka, Eiji, Gonzalez, Frank J., Aoyama, Toshifumi, Kimura, Takefumi, Sugiyama, Eiko, Hara, Atsushi, Wang, Lixuan, Nakajima, Takero, Kamijo, Yuji, Tanaka, Naoki

“…Sulfatides are one of the major sphingoglycolipids in mammalian serum and are synthesized and secreted mainly from the liver as a component of lipoproteins…”
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Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice by Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Kamijo, Yuji, Hara, Atsushi, Hu, Rui, Li, Gang, Li, Yufeng, Nakamura, Kozo, Gonzalez, Frank J., Aoyama, Toshifumi

“…The hypocholesterolemic potential of peroxisome proliferator-activated receptor (PPAR) pan-activator bezafibrate has been documented. However, in addition to…”
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Extraction and analysis of multiple sphingolipids from a single sample by Taketomi, T, Sugiyama, E

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PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice by Harada, Yukiko, Tanaka, Naoki, Ichikawa, Motoki, Kamijo, Yuji, Sugiyama, Eiko, Gonzalez, Frank J., Aoyama, Toshifumi

“…It was reported that 2,4-dichlorophenoxyacetic acid (2,4-D), a commonly used herbicide and a possible endocrine disruptor, can disturb spermatogenesis, but the…”
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Peroxisome proliferator-activated receptor ? protects against alcohol-induced liver damage by Nakajima, Tamie, Kamijo, Yuji, Tanaka, Naoki, Sugiyama, Eiko, Tanaka, Eiji, Kiyosawa, Kendo, Fukushima, Yoshimitsu, Peters, Jeffrey M., Gonzalez, Frank J., Aoyama, Toshifumi

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Association of GM4 ganglioside with the membrane surrounding lipid droplets in shark liver by Li, Yu-Teh, Sugiyama, Eiko, Ariga, Toshio, Nakayama, Jun, Hayama, Masayoshi, Hama, Yoichiro, Nakagawa, Hiroki, Tai, Tadashi, Maskos, Karol, Li, Su-Chen, Kasama, Takeshi, Ksama, Takeshi

“…By TLC, GM4 was found to be the major ganglioside in the liver of six shark species examined: Odontaspis taurus, Negaprion brevirostris, Sphyrna lewini,…”
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Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice by Lu, Yu, Harada, Makoto, Kamijo, Yuji, Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Kyogashima, Mamoru, Gonzalez, Frank J., Aoyama, Toshifumi

“…Peroxisome proliferator-activated receptor α (PPARα) is involved in the regulation of fatty acid and cholesterol metabolism. A high-cholesterol (HC) diet…”
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Confirmation of minor components of less polar neutral and acidic glycolipids in monkey brain tissue by Taketomi, T, Sugiyama, E, Uemura Ki, Hara, A, Hidaka, H, Tozuka, M, Nakabayashi, T, Katsuyama, T

“…Crude glycolipids, prepared without alkali treatment in advance, were separated into neutral and acidic glycolipids by DEAE-Sephadex A-25 (acetate form) column…”
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Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice by Tanaka, Naoki, Zhang, Xiuguo, Sugiyama, Eiko, Kono, Hiroyuki, Horiuchi, Akira, Nakajima, Takero, Kanbe, Hiroki, Tanaka, Eiji, Gonzalez, Frank J., Aoyama, Toshifumi

“…Eicosapentaenoic acid (EPA) in fish oil is known to improve hepatic steatosis. However, it remains unclear whether such action of EPA is actually caused by…”
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Rapid Method of Preparation of Lysoglycosphingolipids and Their Confirmation by Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry by Taketomi, Tamotsu, Hara, Atsushi, Uemura, Kei-ichi, Sugiyama, Eiko

“…We have recently developed a rapid method for the preparation of lysoglycosphingolipids on a small scale, in high yield. This procedure of microwave-mediated…”
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PPAR[alpha]-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice by Harada, Yukiko, Tanaka, Naoki, Ichikawa, Motoki, Kamijo, Yuji, Sugiyama, Eiko, Gonzalez, Frank J, Aoyama, Toshifumi

“…It was reported that 2,4-dichlorophenoxyacetic acid (2,4-D), a commonly used herbicide and a possible endocrine disruptor, can disturb spermatogenesis, but the…”
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Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene by Tian, Yangyang, Yang, Yang, Zhang, Xiaowei, Nakajima, Takero, Tanaka, Naoki, Sugiyama, Eiko, Kamijo, Yuji, Lu, Yu, Moriya, Kyoji, Koike, Kazuhiko, Gonzalez, Frank J., Aoyama, Toshifumi

“…Sulfatides, a type of glycosphingolipid, are associated with carcinogenesis. Peroxisome proliferator-activated receptor α (PPARα) is involved in the regulation…”
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Peroxisome proliferator-activated receptor α protects against alcohol-induced liver damage by NAKAJIMA, Tamie, KAMIJO, Yuji, TANAKA, Naoki, SUGIYAMA, Eiko, TANAKA, Eiji, KIYOSAWA, Kendo, FUKUSHIMA, Yoshimitsu, PETERS, Jeffrey M, GONZALEZ, Frank J, AOYAMA, Toshifumi

“…The mechanisms underlying alcoholic liver disease are not completely understood, but lipid accumulation seems to be central to the cause of this disease. The…”
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