Search Results - "Sugimoto, Yoshiyuki"

Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope by Ikeda, Masahiro, Yamaguchi, Miki, Kato, Kazunori, Nakamura, Kiminori, Shiina, Sagano, Ichikawa-Ando, Takako, Misaka, Hirofumi, Myojo, Kensuke, Nakamura, Kazuyasu, Sugimoto, Yoshiyuki, Hamada, Hirofumi

“…TROP-2 is a type Ⅰ transmembrane glycoprotein that is highly expressed in various epithelial cancer cells, and its increased expression correlates with poor…”
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K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund’s Adjuvant Model by Sugimoto, Yoshiyuki, Kojima, Yozo, Inayoshi, Atsushi, Inoue, Kazuaki, Miura-Kusaka, Hiroko, Mori, Kiyotoshi, Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Nakasato, Yoshisuke, Shirakura, Shiro, Toki, Shin-ichiro, Shinoda, Katsumi, Suzuki, Nobuyuki

“…Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple…”
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Cell Surface Antibody Retention Influences In Vivo Antitumor Activity Mediated by Antibody-dependent Cellular Cytotoxicity by IKEDA, MASAHIRO, KATO, KAZUNORI, YAMAGUCHI, MIKI, HAMADA, HIROFUMI, NAKAMURA, KAZUYASU, SUGIMOTO, YOSHIYUKI

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Cell Surface Antibody Retention Influences In Vivo Antitumor Activity Mediated by Antibody-dependent Cellular Cytotoxicity by Ikeda, Masahiro, Kato, Kazunori, Yamaguchi, Miki, Hamada, Hirofumi, Nakamura, Kazuyasu, Sugimoto, Yoshiyuki

“…Multiple factors affect the in vivo antitumor activity of antibody-based therapeutics; however, the influence of cell surface retention on antibody-dependent…”
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Updated results from the European Randomized Study of Prostate-Specific Antigen （PSA） Screening for Prostate Cancer： are Asian countries encouraged to promote PSA screening by Mikio Sugimoto Yoshiyuki Kakehi

“…An updated result of European Randomized Screening Trial for Prostate Cancer encourages Asian countries to proceed prostate-specific antigen （PSA） screening…”
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The therapeutic potential of a novel PSMA antibody and its IL-2 conjugate in prostate cancer by Sugimoto, Yoshiyuki, Hirota, Maiko, Yoshikawa, Kazuhiro, Sumitomo, Makoto, Nakamura, Kogenta, Ueda, Ryuzo, Niwa, Rinpei, Suzawa, Toshiyuki, Yamasaki, Motoo, Shitara, Kenya, Kato, Takashi, Nakamura, Kazuyasu

“…Prostate-specific membrane antigen (PSMA) is an attractive target for treatment of prostate cancer. Using the PSMA-recognizing mouse monoclonal antibody 2C9…”
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Embossing of Polyester Film Laminated Steel by Morita, Shun-ichi, Iwashita, Hiroyuki, Sugimoto, Yoshiyuki, Shimizu, Nobuyoshi, Maida, Norimasa

“…Polyester film laminated steel for construction material use has been slightly but steadily replacing polyvinyl chloride coated steel from environmental…”
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Myeloperoxidase-Specific Anti-Neutrophil Cytoplasmic Autoantibodies - Related Scleroderma Renal Crisis Treated with Double-Filtration Plasmapheresis by OMOTE, Akiko, MURAMATSU, Masahito, SUGIMOTO, Yoshiyuki, HOSONO, Shimako, MURAKAMI, Ryuichiro, TANAKA, Hitoshi, WATANABE, Yoshiaki, SANO, Hiroshi, KATO, Katsumoto

“…A 46-year-old female patient who was diagnosed with systemic sclerosis (SSc) developed rapidly progressive renal failure without elevation of blood pressure or…”
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Discovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists by Saku, Osamu, Ishida, Hiroshi, Atsumi, Eri, Sugimoto, Yoshiyuki, Kodaira, Hiroshi, Kato, Yoshimitsu, Shirakura, Shiro, Nakasato, Yoshisuke

“…We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we…”
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Chronic alcoholism and evolution of pain and prognosis in chronic pancreatitis by HAYAKAWA, T, KONDO, T, SHIBATA, T, SUGIMOTO, Y, KITAGAWA, M

“…To evaluate the influence of chronic alcoholism on clinical features of chronic pancreatitis in Japan, pain evolution, pancreatic insufficiency, and long-term…”
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Gα12/13 Mediates α1-Adrenergic Receptor–Induced Cardiac Hypertrophy by Maruyama, Yoshiko, Nishida, Motohiro, Sugimoto, Yoshiyuki, Tanabe, Shihori, Turner, Justin H, Kozasa, Tohru, Wada, Teiji, Nagao, Taku, Kurose, Hitoshi

“…ABSTRACT—In neonatal cardiomyocytes, activation of the Gq-coupled α1-adrenergic receptor (α1AR) induces hypertrophy by activating mitogen-activated protein…”
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Mechanism underlying the block of human Cav3.2 T-type Ca2+ channels by benidipine, a dihydropyridine Ca2+ channel blocker by Inayoshi, Atsushi, Sugimoto, Yoshiyuki, Funahashi, Jun, Takahashi, Saori, Matsubara, Masahiro, Kusaka, Hideaki

“…Benidipine, a dihydropyridine Ca2+ channel blocker, has been reported to block T-type Ca2+ channels; however, the mechanism underlying this effect was unclear…”
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A Low-power, 128-Gbit/s, DC-coupled linear driver IC for Electro-absorption Modulated DFB Laser by Misawa, Taichi, Sugimoto, Yoshiyuki, Tanaka, Keiji

“…We demonstrate a 128-Gbit/s/λ optical transmitter with newly developed DC-coupled linear driver IC for electro-absorption modulator. High-quality PAM-4 eye…”
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A 19-dB Peaking at 72-GHz and 4.1-Vppd Output Swing SiGe BiCMOS Linear Driver with Dynamic Cascode Output Buffer by Uemura, Hiroshi, Misawa, Taichi, Itabashi, Naoki, Kurokawa, Munetaka, Sugimoto, Yoshiyuki, Kumagai, Seiji, Takechi, Masaru, Tanaka, Keiji

“…As symbol rate increases over 100 GBd in digital coherent optical communication system, high-frequency loss compensation becomes a critical issue. This paper…”
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A Shunt-Feedback TIA with Common-Base Variable Gain Input Stage for 128-GBaud Coherent Communication by Kumagai, Seiji, Sugimoto, Yoshiyuki, Uemura, Hiroshi, Kurokawa, Munetaka, Itabashi, Naoki, Takechi, Masaru, Okimoto, Takuya, Tanaka, Keiji

“…We present a fully differential linear transimpedance amplifier − (TIA) with a common-base (CB) variable gain circuit as the input stage of a shunt-feedback…”
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80-GHz Bandwidth and High Responsivity of InP Coherent Receiver PIC with Butt-joint waveguide PDs by Okimoto, Takuya, Yagi, Hideki, Ashizawa, Ken, Yamazaki, Kouichiro, Ebihara, Koji, Okamoto, Satoru, Horino, Kazuhiko, Kurokawa, Munetaka, Sugimoto, Yoshiyuki, Kumagai, Seiji, Tanaka, Keiji, Takechi, Masaru, Ekawa, Mitsuru, Yoneda, Yoshihiro

“…An InP-based coherent receiver PIC with waveguide PDs demonstrates 80-GHz bandwidth and high responsivity of 0.156 A/W at a wavelength of 1.55 μm. A coherent…”
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25.78-Gbit/s Burst-mode Receiver for 50G-EPON OLT by TANAKA, Naruto, UMEDA, Daisuke, SUGIMOTO, Yoshiyuki, FUNADA, Tomoyuki, TANAKA, Keiji, OGITA, Shoichi

“…We report the world's first receiver optical sub-assembly equipped with 25G burstmode TIA which is applicable for 50G-EPON OLT transceiver. We demonstrate its…”
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A Compact 212.5-Gbit/s Transmitter Optical Sub-Assembly with DMLs and Quad Linear Driver by Itabashi, Naoki, Sugimoto, Yoshiyuki, Fujimura, Yasushi, Tanaka, Keiji, Ogita, Shoichi

“…We present a compact 212.5-Gbit/s transmitter optical sub-assembly equipped with directly modulated lasers and quad 53.125-Gbit/s linear driver. We demonstrate…”
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Analysis of Phenylephrine-induced hypertrophic response in cardiomyocytes of neonatal rats by adenovirus gene transfer method by Maruyama, Yoshiko, Nishida, Motohiro, Sugimoto, Yoshiyuki, Tanaka, Rie, Nagao, Taku, Kurose, Hitoshi

“…The signal transduction pathways leading the hypertrophy of cardiomyocytes are not well defined. We determined the pattern of activation of various MAP kinases…”
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High Optical Output Power and High-responsivity IC-TROSA for 800 Gbps applications by Kurokawa, Munetaka, Nakayama, Kenichi, Takechi, Masaru, Mizuno, Yasutaka, Misawa, Taichi, Banno, Eiichi, Uemura, Hiroshi, Sugimoto, Yoshiyuki, Kumagai, Seiji, Okimoto, Takuya, Kono, Naoya, Ishikawa, Tsutomu, Hara, Hiroshi, Kato, Takatoshi, Tanaka, Keiji, Ekawa, Mitsuru, Uesaka, Katsumi

“…We developed an Integrated Coherent Transmit-Receive Optical Sub-Assembly (IC-TROSA) type-2 for 800 Gbps applications. The unmodulated optical output power of…”
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