Three Cases of Intravascular Large B-Cell Lymphoma Detected in a Biopsy of Skin Lesions

Intravascular large B-cell lymphoma (IVL) is a rare subtype of extranodal malignant lymphoma. The proliferation of neoplastic B cells within small blood vessels causes eruptions and other symptoms in a variety of organs. The random skin biopsy is useful for diagnosing this condition in its early sta...

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Bibliographic Details
Published in:	Dermatology (Basel) Vol. 232; no. 2; p. 185
Main Authors:	Arai, Takashi, Kato, Yukihiko, Funaki, Maki, Shimamura, Sanae, Yokogawa, Naoto, Sugii, Syoji, Tsuboi, Ryoji
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2016
Subjects:	Aged Aged, 80 and over Biopsy Female Humans Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - pathology Male Skin - pathology Skin Diseases - etiology Skin Diseases - pathology Vascular Neoplasms - complications Vascular Neoplasms - pathology
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Summary:	Intravascular large B-cell lymphoma (IVL) is a rare subtype of extranodal malignant lymphoma. The proliferation of neoplastic B cells within small blood vessels causes eruptions and other symptoms in a variety of organs. The random skin biopsy is useful for diagnosing this condition in its early stages. In order to assess the diagnostic utility of this method, we examined 3 cases with the aim of comparing the occurrence of tumor cells in lesional and healthy-looking skin by performing a random skin biopsy of 32 separate sites. Our findings from the total of 32 biopsy specimens collected from the 3 cases indicated that 16 of the 17 sites on the lesional skin and 1 of the 15 sites on the healthy-looking skin were positive for neoplastic cells. This finding suggested that IVL cells occurred more frequently in the lesional skin than in the healthy-looking skin.
ISSN:	1421-9832
DOI:	10.1159/000437363