Search Results - "Sugihara, Takaaki"

YAP and the Hippo pathway in cholangiocarcinoma by Sugihara, Takaaki, Isomoto, Hajime, Gores, Gregory, Smoot, Rory

“…Cholangiocarcinoma (CCA) has an increasing incidence and remains a difficult to treat malignancy. In a search for more effective treatment options, progress…”
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Anhydrous proton-conducting material consisting of basic protein protamine by Yamada, Masanori, Sugihara, Takaaki, Yamada, Tetsuya

“…[Display omitted] •Protein composite material indicates anhydrous proton conductivity.•Basic protein protamine and acid molecule form an acid-base…”
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Steatosis is involved in the progression of kidney disease in a high-fat-diet-induced non-alcoholic steatohepatitis mouse model by Hamada, Shintaro, Takata, Tomoaki, Yamada, Kentaro, Yamamoto, Marie, Mae, Yukari, Iyama, Takuji, Ikeda, Suguru, Kanda, Tsutomu, Sugihara, Takaaki, Isomoto, Hajime

“…Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health issues associated with the metabolic syndrome. Although NASH is a known…”
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YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity by Sugihara, Takaaki, Werneburg, Nathan W, Hernandez, Matthew C, Yang, Lin, Kabashima, Ayano, Hirsova, Petra, Yohanathan, Lavanya, Sosa, Carlos, Truty, Mark J, Vasmatzis, George, Gores, Gregory J, Smoot, Rory L

“…The Hippo pathway effector, Yes-associated protein (YAP), is a transcriptional coactivator implicated in cholangiocarcinoma (CCA) pathogenesis. YAP is known to…”
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Fluorescence Imaging Using Enzyme-Activatable Probes for Detecting Diabetic Kidney Disease and Glomerular Diseases by Yamada, Kentaro, Takata, Tomoaki, Iyama, Takuji, Hamada, Shintaro, Mae, Yukari, Sugihara, Takaaki, Isomoto, Hajime

“…A clear identification of the etiology of glomerular disease is essential in patients with diabetes. Renal biopsy is the gold standard for assessing the…”
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5-Aminolevulinic Acid Attenuates Glucose-Regulated Protein 78 Expression and Hepatocyte Lipoapoptosis via Heme Oxygenase-1 Induction by Hashimoto, Takaaki, Sugihara, Takaaki, Kanda, Tsutomu, Takata, Tomoaki, Isomoto, Hajime

“…Endoplasmic reticulum (ER) stress plays a pivotal role in the progression of steatohepatitis. 5-aminolevulinic acid (5-ALA), a precursor in the heme…”
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Treatment of Digital Ulcers and Reflux Oesophagitis in a Patient with Systemic Sclerosis: Increased Risk of Hepatotoxicity due to a Potential Drug-drug Interaction Between Bosentan and Vonoprazan by Kimura, Ryoko, Sugita, Kazunari, Sugihara, Takaaki, Isomoto, Hajime, Yamamoto, Osamu

“…Abstract is missing (Short communication)…”
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Investigating the role of heat shock protein 47 in fibrosis in Crohn’s disease by Kurumi, Hiroki, Takata, Tomoaki, Kanda, Tsutomu, Sugihara, Takaaki, Kakugawa, Tomoyuki, Yokota, Shin-ichi, Morisaki, Tomohito, Akashi, Taro, Isomoto, Hajime

“…Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share similar genetic risk factors…”
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Platelet‐derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation by Smoot, Rory L., Werneburg, Nathan W., Sugihara, Takaaki, Hernandez, Matthew C., Yang, Lin, Mehner, Christine, Graham, Rondell P., Bronk, Steven F., Truty, Mark J., Gores, Gregory J.

“…The Hippo pathway effector YAP is implicated in the pathogenesis of cholangiocarcinoma (CCA). The Hippo pathway relies on signaling cross talk for its…”
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Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal Tubules by Hamada, Shintaro, Mae, Yukari, Takata, Tomoaki, Hanada, Hinako, Kubo, Misaki, Taniguchi, Sosuke, Iyama, Takuji, Sugihara, Takaaki, Isomoto, Hajime

“…Steatosis, or ectopic lipid deposition, is the fundamental pathophysiology of non-alcoholic steatohepatitis and chronic kidney disease. Steatosis in the renal…”
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Uromodulin Regulates Murine Aquaporin−2 Activity via Thick Ascending Limb–Collecting Duct Cross−Talk during Water Deprivation by Takata, Tomoaki, Hamada, Shintaro, Mae, Yukari, Iyama, Takuji, Ogihara, Ryohei, Seno, Misako, Nakamura, Kazuomi, Takata, Miki, Sugihara, Takaaki, Isomoto, Hajime

“…Uromodulin, a urinary protein synthesized and secreted from the thick ascending limb (TAL) of the loop of Henle, is associated with hypertension through the…”
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Infective Endocarditis-Associated Glomerulonephritis : A Comprehensive Review of the Clinical Presentation, Histopathology, and Management by Takata, Tomoaki, Mae, Yukari, Sugihara, Takaaki, Isomoto, Hajime

“…[ABSTRACT] A significant proportion of patients with infective endocarditis presents with acute renal failure related to infective endocarditis-associated…”
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Renal Ultrasound Elastography: A Review of the Previous Reports on Chronic Kidney Diseases by Iyama, Takuji, Sugihara, Takaaki, Takata, Tomoaki, Isomoto, Hajime

“…The early detection of a kidney injury is essential to protect against the progression of kidney damage owing to the progressive nature of chronic kidney…”
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A novel method for assessing the renal biopsy specimens using an activatable fluorescent probe by Iyama, Takuji, Takata, Tomoaki, Yamada, Kentaro, Mae, Yukari, Taniguchi, Sosuke, Ida, Ayami, Ogawa, Masaya, Yamamoto, Marie, Hamada, Shintaro, Fukuda, Satoko, Kanda, Tsutomu, Sugihara, Takaaki, Isomoto, Hajime, Urano, Yasuteru

“…Gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is an activatable fluorescent probe that can be activated by γ-glutamyltranspeptidase (GGT). The…”
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Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules by Hosokawa, Kohshiro, Takata, Tomoaki, Sugihara, Takaaki, Matono, Tomomitsu, Koda, Masahiko, Kanda, Tsutomu, Taniguchi, Sosuke, Ida, Ayami, Mae, Yukari, Yamamoto, Marie, Iyama, Takuji, Fukuda, Satoko, Isomoto, Hajime

“…Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health burdens closely related to metabolic syndrome. A link between CKD and…”
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Fusion Imaging Objectively Demonstrates Improved Pancreas Visualization through Manipulation Techniques: A Prospective Interventional Study by Matsumoto, Kazuya, Kakite, Suguru, Sugihara, Takaaki, Yamashita, Eijiro, Miyoshi, Kenichi, Onoyama, Takumi, Kawata, Soichiro, Ikebuchi, Yuichiro, Takeda, Yohei, Koda, Hiroki, Yamashita, Taro, Yamaguchi, Naoyuki, Koda, Masahiko, Isomoto, Hajime

“…Objective Abdominal ultrasonography (AUS) is used to screen for abdominal diseases owing to its low cost, safety, and accessibility. However, the detection…”
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Serum miR-379 expression is related to the development and progression of hypercholesterolemia in non-alcoholic fatty liver disease by Okamoto, Kinya, Koda, Masahiko, Okamoto, Toshiaki, Onoyama, Takumi, Miyoshi, Kenichi, Kishina, Manabu, Matono, Tomomitsu, Kato, Jun, Tokunaga, Shiho, Sugihara, Takaaki, Hiramatsu, Akira, Hyogo, Hideyuki, Tobita, Hiroshi, Sato, Shuichi, Kawanaka, Miwa, Hara, Yuichi, Hino, Keisuke, Chayama, Kazuaki, Murawaki, Yoshikazu, Isomoto, Hajime

“…Non-alcoholic fatty liver disease (NAFLD) has a wide spectrum, eventually leading to cirrhosis and hepatic carcinogenesis. We previously reported that a series…”
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Photosensitizer verteporfin inhibits the growth of YAP‑ and TAZ‑dominant gastric cancer cells by suppressing the anti‑apoptotic protein Survivin in a light‑independent manner by Takashi, Hasegawa, Takaaki, Sugihara, Yoshiki, Hoshino, Ryohei, Tarumoto, Yukako, Matsuki, Tsutomu, Kanda, Tomoaki, Takata, Takakazu, Nagahara, Tomomitsu, Matono, Hajime, Isomoto

“…Yes-associated protein (YAP) positivity indicates a poor prognosis in gastric cancer. Transcriptional co-activator with a PDZ-binding domain (TAZ), a YAP…”
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Renal tubular acidosis without interstitial nephritis in Sjögren’s syndrome: a case report and review of the literature by Hamada, Shintaro, Takata, Tomoaki, Yamada, Kentaro, Yamamoto, Marie, Mae, Yukari, Iyama, Takuji, Sugihara, Takaaki, Takata, Miki, Isomoto, Hajime

“…Abstract Background Renal tubular acidosis is the principal clinical feature associated with tubulointerstitial nephritis in patients with primary Sjögren’s…”
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Chronic Active Epstein-Barr Virus Infection Indistinguishable from Autoimmune Hepatitis : A Case Report by Ikeda, Suguru, Sugihara, Takaaki, Kihara, Takuya, Hoshino, Yoshiki, Matsuki, Yukako, Nagahara, Takakazu, Oyama, Kenji, Okano, Jun-Ichi, Kuwamoto, Satoshi, Horie, Yasushi, Isomoto, Hajime

“…[ABSTRACT] Chronic active Epstein-Barr virus (CAEBV) infection is a rare disease, mainly affecting children, typically characterized by persistent infectious…”
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