Seroprevalence to Bartonella quintana among Patients at a Community Clinic in Downtown Seattle

Seroprevalence to Bartonella quintana among Patients at a Community Clinic in Downtown Seattle

In 1993, an outbreak of 10 cases of Bartonella quintana bacteremia occurred among homeless, alcoholic, human immunodeficiency virus (HIV)-negative persons in Seattle. To estimate the prevalence of past exposure B. quintana among this population, a serosurvey was conducted in 1994 among patients at a...

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Bibliographic Details
Published in:The Journal of infectious diseases Vol. 173; no. 4; pp. 1023 - 1026
Main Authors: Jackson, Lisa A., Spaeh, David H., Kippen, Deborah A., Sugg, Naney K., Regnery, Russell L., Sayers, Merlyn H., Stamm, Walter E.
Format: Journal Article
Language:English
Published: United States The University of Chicago Press 01-04-1996
University of Chicago Press
Subjects:
Adolescent
Adult
AIDS/HIV
Alcohol abuse
Alcoholism
Antibodies, Bacterial - analysis
Bartonella
Bartonella quintana
Bartonella quintana - immunology
Blood
Blood donation
Cat scratch fever
Community Health Centers
Concise Communications
Epidemiology
Female
Homeless Persons
Homelessness
Humans
Infections
Male
Middle Aged
Risk Factors
Seroepidemiologic studies
Serologic Tests
Trench Fever - epidemiology
Washington
Washington
USA, Washington, Seattle
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Summary:In 1993, an outbreak of 10 cases of Bartonella quintana bacteremia occurred among homeless, alcoholic, human immunodeficiency virus (HIV)-negative persons in Seattle. To estimate the prevalence of past exposure B. quintana among this population, a serosurvey was conducted in 1994 among patients at a downtown Seattle clinic. Microimmunoftuorescent titers to B. quintana in 192 clinic patients were compared with titers in 199 age- and sex-matched Seattle volunteer blood donors. Titers ⩾64 were detected in 20% (39/192) of clinic patients compared with 2% (4/199) of blood donors (P < .001). Among clinic patients, alcohol abuse was independently associated in multivariate analysis with titers ⩾64 (odds ratio, 3.3; 95% confidence interval, 1.6–6.9). Of the 39 patients with B. quintana titers ⩾64,24 (62%) also had titers ⩾64 to Bartonella henselae, indicating serologic cross-reactivity between Bartonella species. These results suggest that a substantial proportion of this indigent, inner-city Seattle population was infected with B. quintana.
Bibliography:istex:193E63C2AA23269451E31DF55E1CE729553671E6
Reprints or correspondence: Dr. Lisa Jackson, Dept. of Epidemiology, Box 357236, Seattle, WA 98195-7236.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/173.4.1023