Search Results - "Sugawara, Shigeki"
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Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo
Published in PloS one (03-01-2018)“…Malignant mesothelioma is an aggressive cancer that results from exposure to asbestos. The therapeutic options for this type of cancer are limited; therefore,…”
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Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells
Published in Biomedicines (01-08-2023)“…Metastatic renal cell carcinoma (RCC) is not sufficiently responsive to anticancer drugs, and thus, developing new drugs for advanced RCC remains vital. We…”
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Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells
Published in Molecules (Basel, Switzerland) (21-10-2018)“…Sialic acid-binding lectin from eggs (cSBL) is a multifunctional protein that has lectin and ribonuclease activity. In this study, the anti-tumor activities of…”
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Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells
Published in Glycobiology (Oxford) (28-09-2020)“…Abstract New treatment protocols are aiming to reduce the dose of the multitargeted tyrosine kinase inhibitor sunitinib, as sunitinib elicits many adverse…”
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A Lectin from the Mussel Mytilus galloprovincialis Has a Highly Novel Primary Structure and Induces Glycan-mediated Cytotoxicity of Globotriaosylceramide-expressing Lymphoma Cells
Published in The Journal of biological chemistry (28-12-2012)“…A novel lectin structure was found for a 17-kDa α-d-galactose-binding lectin (termed “MytiLec”) isolated from the Mediterranean mussel, Mytilus…”
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Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma
Published in Oncotarget (27-06-2017)“…Malignant mesothelioma is an aggressive cancer with limited therapeutic options. Sialic acid-binding lectin isolated from Rana catesbeiana oocytes (cSBL) is a…”
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Sialidase NEU3 Contributes to the Invasiveness of Bladder Cancer
Published in Biomedicines (01-01-2024)“…Bladder cancer is the 10th most commonly diagnosed cancer worldwide. The current standard treatment for advanced bladder cancer is neoadjuvant cisplatin…”
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A GM1b/asialo‐GM1 oligosaccharide‐binding R‐type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases
Published in The FEBS journal (01-06-2020)“…A 15‐kDa lectin, termed SeviL, was isolated from Mytilisepta virgata (purplish bifurcate mussel). SeviL forms a noncovalent dimer that binds strongly to…”
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RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells
Published in International journal of oncology (01-10-2016)“…Sialic acid-binding lectin obtained from bullfrog eggs (SBL) induces cell death in cancer cells but not in normal cells. This antitumor effect is mediated…”
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Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells
Published in International journal of oncology (01-11-2013)“…Sialic acid binding lectin (SBL) isolated from Rana catesbeiana oocytes is a multifunctional protein which has lectin activity, ribonuclease activity and…”
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Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs
Published in International journal of oncology (01-12-2013)“…Sialic-acid binding lectin (SBL) isolated from bullfrog (Rana catesbeiana) oocytes is a multifunctional protein which has lectin activity, ribonuclease…”
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Catfish rhamnose-binding lectin induces G0/1 cell cycle arrest in Burkitt’s lymphoma cells via membrane surface Gb3
Published in Glycoconjugate journal (01-02-2017)“…Silurus asotus egg lectin (SAL), an α-galactoside-binding protein isolated from the eggs of catfish, is a member of the rhamnose-binding lectin family that…”
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MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways
Published in Marine drugs (14-12-2015)“…MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3:…”
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Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)
Published in Oncology reports (01-01-2014)“…Heat shock proteins (Hsps) are molecular chaperones that maintain homeostasis of organisms. In regards to the Hsps, many studies have investigated the…”
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Leczyme : A New Candidate Drug for Cancer Therapy
Published in BioMed research international (01-01-2014)“…Sialic acid-binding lectin (SBL), isolated from oocytes of Rana catesbeiana, is leczyme and has both lectin and ribonuclease (RNase) activities. A remarkable…”
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Binding profiles and cytokine-inducing effects of fish rhamnose-binding lectins on Burkitt’s lymphoma Raji cells
Published in Fish physiology and biochemistry (01-10-2014)“…Rhamnose-binding lectin (RBL) is one of the animal lectin categories which take part in the innate immune responses of fish. Osmerus lanceolatus lectin (OLL)…”
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Cancer-selective induction of apoptosis by leczyme
Published in Frontiers in oncology (01-01-2014)“…Sialic acid-binding lectin (SBL) is a multi-functional protein that is isolated from oocytes of Rana catesbeiana. It has both lectin and ribonuclease (enzyme)…”
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Correction: Hasan, I., et al. A Galactose-Binding Lectin Isolated from Aplysia kurodai (Sea Hare) Eggs Inhibits Streptolysin-Induced Hemolysis. Molecules 2014, 19, 13990-14003
Published in Molecules (Basel, Switzerland) (21-01-2016)“…The authors wish to make the following correction to their paper [1]. [...]…”
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A galactose-binding lectin isolated from Aplysia kurodai (sea hare) eggs inhibits streptolysin-induced hemolysis
Published in Molecules (Basel, Switzerland) (05-09-2014)“…A specific galactose-binding lectin was shown to inhibit the hemolytic effect of streptolysin O (SLO), an exotoxin produced by Streptococcus pyogenes…”
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Alteration of Gene Expression Induced by Silurus asotus Lectin in Burkitt's Lymphoma Cells
Published in Biological & Pharmaceutical Bulletin (01-05-2008)“…Silurus asotus lectin (SAL) is a member of the rhamnose-binding lectin (RBL) family, and recognizes globotriaosylceramide (Gb3) on the cell surface of…”
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