Search Results - "Sugawa, Michiru"

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex by Frenzel, Monika, Rommelspacher, Hans, Sugawa, Michiru D., Dencher, Norbert A.

“…Activity and stability of life-supporting proteins are determined not only by their abundance and by post-translational modifications, but also by specific…”
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Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease by Kuter, Katarzyna, Kratochwil, Manuela, Berghauzen-Maciejewska, Klemencja, Głowacka, Urszula, Sugawa, Michiru D., Ossowska, Krystyna, Dencher, Norbert A.

“…In Parkinson's disease (PD) motor symptoms are not observed until loss of 70% of dopaminergic neurons in substantia nigra (SN), preventing early diagnosis…”
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Native DIGE proteomic analysis of mitochondria from substantia nigra and striatum during neuronal degeneration and its compensation in an animal model of early Parkinson's disease by Kuter, Katarzyna, Kratochwil, Manuela, Marx, Sven-Hendric, Hartwig, Sonja, Lehr, Stephan, Sugawa, Michiru D., Dencher, Norbert A.

“…Cause of Parkinson's disease (PD) is still not understood. Motor symptoms are not observed at early stages of disease due to compensatory processes…”
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Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction by Kim, Sang-Eun, Mori, Ryoichi, Komatsu, Toshimitsu, Chiba, Takuya, Hayashi, Hiroko, Park, Seongjoon, Sugawa, Michiru D., Dencher, Norbert A., Shimokawa, Isao

“…Calorie restriction (CR), a non-genetic intervention that promotes longevity in animals, may exert anti-aging effects by modulating mitochondrial function…”
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Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria by Dani, Diksha, Shimokawa, Isao, Komatsu, Toshimitsu, Higami, Yoshikazu, Warnken, Uwe, Schokraie, Elham, Schnölzer, Martina, Krause, Frank, Sugawa, Michiru D., Dencher, Norbert A.

“…Mitochondria being the major source and target of reactive oxygen species (ROS) play a crucial role during ageing. We analyzed ageing and calorie restriction…”
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Age-related alteration in signal transduction: involvement of the cAMP cascade by Sugawa, M, May, T

“…In the present study, we have investigated the involvement of the cAMP signal transduction pathways in young and aged rats. A significantly higher endogenous…”
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Proteome Alterations in Rat Mitochondria Caused by Aging by DENCHER, NORBERT A., FRENZEL, MONIKA, REIFSCHNEIDER, NICOLE H., SUGAWA, MICHIRU, KRAUSE, FRANK

“…:  Analysis of the protein profile of mitochondria and its age‐dependent variation is a promising approach to unravel mechanisms involved in aging and…”
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Defining the Mitochondrial Proteomes from Five Rat Organs in a Physiologically Significant Context Using 2D Blue-Native/SDS-PAGE by Reifschneider, Nicole H, Goto, Sataro, Nakamoto, Hideko, Takahashi, Ryoya, Sugawa, Michiru, Dencher, Norbert A, Krause, Frank

“…In accordance with their manifold tasks, various dysfunctions of mitochondria are critically involved in a large number of diseases and the aging process. This…”
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Supramolecular organisation of OxPhos complexes changes during ageing in various brain regions to a different extent by Frenzel, Monika, Rommelspacher, Hans, Sugawa, Michiru D., Dencher, Norbert A.

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Unraveling Age-Dependent Variation of the Mitochondrial Proteome by DENCHER, NORBERT A., GOTO, SATARO, REIFSCHNEIDER, NICOLE H., SUGAWA, MICHIRU, KRAUSE, FRANK

“…:  Blue‐native and colorless‐native gel electrophoresis combined with subsequent 2D‐SDS‐PAGE and MALDI mass spectrometry are successfully applied for…”
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Alterations of inositol phosphate turnover in striatum of aged rats by Sugawa, M

“…Age-related inositol phosphate turnover in the rat central nervous system was investigated. Higher phospholipase-C activity and drastically higher (almost…”
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Altered dopamine receptor mediated signal transmission in the striatum of aged rats by May, T, Sugawa, M

“…Striatal membranes of very old (40 months) as against young (3 months) female Wistar rats were used. Binding saturation experiments with [3H]SCH 23390 at the…”
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