Search Results - "Sugano, Sumio"

Extreme value theory as a framework for understanding mutation frequency distribution in cancer genomes by Tokutomi, Natsuki, Nakai, Kenta, Sugano, Sumio

“…Currently, the population dynamics of preclonal cancer cells before clonal expansion of tumors has not been sufficiently addressed thus far. By focusing on…”
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Integrated molecular analysis of clear-cell renal cell carcinoma by Sato, Yusuke, Yoshizato, Tetsuichi, Shiraishi, Yuichi, Maekawa, Shigekatsu, Okuno, Yusuke, Kamura, Takumi, Shimamura, Teppei, Sato-Otsubo, Aiko, Nagae, Genta, Suzuki, Hiromichi, Nagata, Yasunobu, Yoshida, Kenichi, Kon, Ayana, Suzuki, Yutaka, Chiba, Kenichi, Tanaka, Hiroko, Niida, Atsushi, Fujimoto, Akihiro, Tsunoda, Tatsuhiko, Morikawa, Teppei, Maeda, Daichi, Kume, Haruki, Sugano, Sumio, Fukayama, Masashi, Aburatani, Hiroyuki, Sanada, Masashi, Miyano, Satoru, Homma, Yukio, Ogawa, Seishi

“…Seishi Ogawa and colleagues report an integrated genomics analysis of more than 100 clear-cell renal carcinoma samples. They analyze whole genomes or exomes,…”
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Frequent pathway mutations of splicing machinery in myelodysplasia by Yoshida, Kenichi, Sanada, Masashi, Shiraishi, Yuichi, Nowak, Daniel, Nagata, Yasunobu, Yamamoto, Ryo, Sato, Yusuke, Sato-Otsubo, Aiko, Kon, Ayana, Nagasaki, Masao, Chalkidis, George, Suzuki, Yutaka, Shiosaka, Masashi, Kawahata, Ryoichiro, Yamaguchi, Tomoyuki, Otsu, Makoto, Obara, Naoshi, Sakata-Yanagimoto, Mamiko, Ishiyama, Ken, Mori, Hiraku, Nolte, Florian, Hofmann, Wolf-Karsten, Miyawaki, Shuichi, Sugano, Sumio, Haferlach, Claudia, Koeffler, H. Phillip, Shih, Lee-Yung, Haferlach, Torsten, Chiba, Shigeru, Nakauchi, Hiromitsu, Miyano, Satoru, Ogawa, Seishi

“…Myelodysplastic syndromes and related disorders (myelodysplasia) are a heterogeneous group of myeloid neoplasms showing deregulated blood cell production with…”
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Draft Assembly of the Symbiodinium minutum Nuclear Genome Reveals Dinoflagellate Gene Structure by Shoguchi, Eiichi, Shinzato, Chuya, Kawashima, Takeshi, Gyoja, Fuki, Mungpakdee, Sutada, Koyanagi, Ryo, Takeuchi, Takeshi, Hisata, Kanako, Tanaka, Makiko, Fujiwara, Mayuki, Hamada, Mayuko, Seidi, Azadeh, Fujie, Manabu, Usami, Takeshi, Goto, Hiroki, Yamasaki, Shinichi, Arakaki, Nana, Suzuki, Yutaka, Sugano, Sumio, Toyoda, Atsushi, Kuroki, Yoko, Fujiyama, Asao, Medina, Mónica, Coffroth, Mary Alice, Bhattacharya, Debashish, Satoh, Nori

“…Dinoflagellates are known for their capacity to form harmful blooms (e.g., “red tides”) and as symbiotic, photosynthetic partners for corals. These unicellular…”
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Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines by Suzuki, Ayako, Makinoshima, Hideki, Wakaguri, Hiroyuki, Esumi, Hiroyasu, Sugano, Sumio, Kohno, Takashi, Tsuchihara, Katsuya, Suzuki, Yutaka

“…Here we conducted an integrative multi-omics analysis to understand how cancers harbor various types of aberrations at the genomic, epigenomic and…”
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Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment by Suzuki, Ayako, Matsushima, Koutatsu, Makinoshima, Hideki, Sugano, Sumio, Kohno, Takashi, Tsuchihara, Katsuya, Suzuki, Yutaka

“…To understand the heterogeneous behaviors of individual cancer cells, it is essential to investigate gene expression levels as well as their divergence between…”
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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species by Suzuki, Sawako, Tanaka, Tomoaki, Poyurovsky, Masha V., Nagano, Hidekazu, Mayama, Takafumi, Ohkubo, Shuichi, Lokshin, Maria, Hosokawa, Hiroyuki, Nakayama, Toshinori, Suzuki, Yutaka, Sugano, Sumio, Sato, Eiichi, Nagao, Toshitaka, Yokote, Koutaro, Tatsuno, Ichiro, Prives, Carol

“…We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a key enzyme in conversion of glutamine to glutamate, and thereby a…”
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A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly by Nishikawa, Hideki, Iijima, Takuro, Kajitani, Rei, Yamaguchi, Junichi, Ando, Toshiya, Suzuki, Yutaka, Sugano, Sumio, Fujiyama, Asao, Kosugi, Shunichi, Hirakawa, Hideki, Tabata, Satoshi, Ozaki, Katsuhisa, Morimoto, Hiroya, Ihara, Kunio, Obara, Madoka, Hori, Hiroshi, Itoh, Takehiko, Fujiwara, Haruhiko

“…Haruhiko Fujiwara and colleagues report the genome sequences of two swallowtail butterfly species, Papilio xuthus and Papilio polytes , and the identification…”
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MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells by Murayama, Takahiko, Takeuchi, Yasuto, Yamawaki, Kaoru, Natsume, Toyoaki, Li, Mengjiao, Marcela, Rojas‐Chaverra N., Nishimura, Tatsunori, Kogure, Yuta, Nakata, Asuka, Tominaga, Kana, Sasahara, Asako, Yano, Masao, Ishikawa, Satoko, Ohta, Tetsuo, Ikeda, Kazuhiro, Horie‐Inoue, Kuniko, Inoue, Satoshi, Seki, Masahide, Suzuki, Yutaka, Sugano, Sumio, Enomoto, Takayuki, Tanabe, Masahiko, Tada, Kei‐ichiro, Kanemaki, Masato T., Okamoto, Koji, Tojo, Arinobu, Gotoh, Noriko

“…Cancer stem‐like cells (CSCs) induce drug resistance and recurrence of tumors when they experience DNA replication stress. However, the mechanisms underlying…”
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Identification of physical interactions between genomic regions by enChIP‐Seq by Fujita, Toshitsugu, Yuno, Miyuki, Suzuki, Yutaka, Sugano, Sumio, Fujii, Hodaka

“…Physical interactions between genomic regions play critical roles in the regulation of genome functions, including gene expression. Here, we show the…”
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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia by Tanaka, Satomi, Miyagi, Satoru, Sashida, Goro, Chiba, Tetsuhiro, Yuan, Jin, Mochizuki-Kashio, Makiko, Suzuki, Yutaka, Sugano, Sumio, Nakaseko, Chiaki, Yokote, Koutaro, Koseki, Haruhiko, Iwama, Atsushi

“…EZH2, a catalytic component of the polycomb repressive complex 2, trimethylates histone H3 at lysine 27 (H3K27) to repress the transcription of target genes…”
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Genome sequence and analysis of the Japanese morning glory Ipomoea nil by Hoshino, Atsushi, Jayakumar, Vasanthan, Nitasaka, Eiji, Toyoda, Atsushi, Noguchi, Hideki, Itoh, Takehiko, Shin-I, Tadasu, Minakuchi, Yohei, Koda, Yuki, Nagano, Atsushi J., Yasugi, Masaki, Honjo, Mie N., Kudoh, Hiroshi, Seki, Motoaki, Kamiya, Asako, Shiraki, Toshiyuki, Carninci, Piero, Asamizu, Erika, Nishide, Hiroyo, Tanaka, Sachiko, Park, Kyeung-Il, Morita, Yasumasa, Yokoyama, Kohei, Uchiyama, Ikuo, Tanaka, Yoshikazu, Tabata, Satoshi, Shinozaki, Kazuo, Hayashizaki, Yoshihide, Kohara, Yuji, Suzuki, Yutaka, Sugano, Sumio, Fujiyama, Asao, Iida, Shigeru, Sakakibara, Yasubumi

“…Ipomoea is the largest genus in the family Convolvulaceae. Ipomoea nil (Japanese morning glory) has been utilized as a model plant to study the genetic basis…”
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The Endosymbiotic Bacterium Wolbachia Selectively Kills Male Hosts by Targeting the Masculinizing Gene by Fukui, Takahiro, Kawamoto, Munetaka, Shoji, Keisuke, Kiuchi, Takashi, Sugano, Sumio, Shimada, Toru, Suzuki, Yutaka, Katsuma, Susumu

“…Pathogens are known to manipulate the reproduction and development of their hosts for their own benefit. Wolbachia is an endosymbiotic bacterium that infects a…”
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Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders by Muto, Tomoya, Sashida, Goro, Oshima, Motohiko, Wendt, George R, Mochizuki-Kashio, Makiko, Nagata, Yasunobu, Sanada, Masashi, Miyagi, Satoru, Saraya, Atsunori, Kamio, Asuka, Nagae, Genta, Nakaseko, Chiaki, Yokote, Koutaro, Shimoda, Kazuya, Koseki, Haruhiko, Suzuki, Yutaka, Sugano, Sumio, Aburatani, Hiroyuki, Ogawa, Seishi, Iwama, Atsushi

“…Polycomb group (PcG) proteins are essential regulators of hematopoietic stem cells. Recent extensive mutation analyses of the myeloid malignancies have…”
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Large-scale DNA Barcode Library Generation for Biomolecule Identification in High-throughput Screens by Lyons, Eli, Sheridan, Paul, Tremmel, Georg, Miyano, Satoru, Sugano, Sumio

“…High-throughput screens allow for the identification of specific biomolecules with characteristics of interest. In barcoded screens, DNA barcodes are linked to…”
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Screening for possible miRNA–mRNA associations in a colon cancer cell line by Kanematsu, Sotaro, Tanimoto, Kousuke, Suzuki, Yutaka, Sugano, Sumio

“…MicroRNAs (miRNAs) are small non-coding RNAs mediating the regulation of gene expression in various biological contexts, including carcinogenesis. Here, we…”
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DBTSS/DBKERO for integrated analysis of transcriptional regulation by Suzuki, Ayako, Kawano, Shin, Mitsuyama, Toutai, Suyama, Mikita, Kanai, Yae, Shirahige, Katsuhiko, Sasaki, Hiroyuki, Tokunaga, Katsushi, Tsuchihara, Katsuya, Sugano, Sumio, Nakai, Kenta, Suzuki, Yutaka

“…Abstract DBTSS (Database of Transcriptional Start Sites)/DBKERO (Database of Kashiwa Encyclopedia for human genome mutations in Regulatory regions and their…”
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CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes by Yoshitane, Hikari, Ozaki, Haruka, Terajima, Hideki, Du, Ngoc-Hien, Suzuki, Yutaka, Fujimori, Taihei, Kosaka, Naoki, Shimba, Shigeki, Sugano, Sumio, Takagi, Toshihisa, Iwasaki, Wataru, Fukada, Yoshitaka

“…In mammalian circadian clockwork, the CLOCK-BMAL1 complex binds to DNA enhancers of target genes and drives circadian oscillation of transcription. Here we…”
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A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins by Negishi, Masamitsu, Wongpalee, Somsakul P, Sarkar, Sukumar, Park, Jonghoon, Lee, Kyung Yong, Shibata, Yoshiyuki, Reon, Brian J, Abounader, Roger, Suzuki, Yutaka, Sugano, Sumio, Dutta, Anindya

“…Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many of which have no known function. CDKN1A/p21 is an important…”
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DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data by Suzuki, Ayako, Wakaguri, Hiroyuki, Yamashita, Riu, Kawano, Shin, Tsuchihara, Katsuya, Sugano, Sumio, Suzuki, Yutaka, Nakai, Kenta

“…DBTSS (http://dbtss.hgc.jp/) was originally constructed as a collection of uniquely determined transcriptional start sites (TSSs) in humans and some other…”
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