Search Results - "Sugai, Shoichiro"

Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity by Kobayashi, Akio, Suzuki, Yusuke, Sugai, Shoichiro

“…The activities of the transaminases (aminotransferases) alanine aminotransferase and aspartate aminotransferase in the blood (serum or plasma) are widely used…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Hashimoto, Tatsuji, Toyoda, Kaoru, Takahashi, Tadakazu, Kobayashi, Akio, Sugai, Shoichiro, Yoshinari, Kouichi

“…Some patients encounter hepatotoxicity after repeated acetaminophen (APAP) dosing even at therapeutic doses. In the present study, we focused on the diabetic…”
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Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis by Goda, Keisuke, Saito, Kosuke, Muta, Kyotaka, Kobayashi, Akio, Saito, Yoshiro, Sugai, Shoichiro

“…Valproic acid (VPA) is known to induce hepatic steatosis due to mitochondrial toxicity in rodents and humans. In the present study, we administered VPA to SD…”
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Arachidonic acid‐containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen‐induced hepatic phospholipidosis by Saito, Kosuke, Goda, Keisuke, Kobayashi, Akio, Yamada, Naohito, Maekawa, Kyoko, Saito, Yoshiro, Sugai, Shoichiro

“…Lipid profiling has emerged as an effective approach to not only screen disease and drug toxicity biomarkers but also understand their underlying mechanisms of…”
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High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats by Toyoda, Kaoru, Suzuki, Yusuke, Muta, Kyotaka, Masuyama, Taku, Kakimoto, Kochi, Kobayashi, Akio, Shoda, Toshiyuki, Sugai, Shoichiro

“…Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple…”
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Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury by Goda, Keisuke, Takahashi, Tadakazu, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Drug-induced liver injury (DILI) is one of the serious and frequent drug-related adverse events. This adverse event is a main reason for regulatory action…”
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A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor by Yokoyama, Hideaki, Kobayashi, Akio, Kondo, Kazuma, Oshida, Shin-ichi, Takahashi, Tadakazu, Masuyama, Taku, Shoda, Toshiyuki, Sugai, Shoichiro

“…Acyl CoA: diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the re-synthesis of triglycerides (TG) from free fatty acids and diacylglycerol…”
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Evaluation of the Potential Risk of Drugs to Induce Hepatotoxicity in Human-Relationships between Hepatic Steatosis Observed in Non-Clinical Toxicity Study and Hepatotoxicity in Humans by Goda, Keisuke, Kobayashi, Akio, Takahashi, Akemi, Takahashi, Tadakazu, Saito, Kosuke, Maekawa, Keiko, Saito, Yoshiro, Sugai, Shoichiro

“…In the development of drugs, we sometimes encounter fatty change of the hepatocytes (steatosis) which is not accompanied by degenerative change in the liver in…”
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Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Leprfa (SDT fatty) rats by Takahashi, Tadakazu, Matsuura, Chizuru, Toyoda, Kaoru, Suzuki, Yusuke, Yamada, Naohito, Kobayashi, Akio, Sugai, Shoichiro, Shimoi, Kayoko

“…In order to estimate the potential risk of chemicals including drug in patients with type 2 diabetes mellitus (T2DM), we investigated allyl alcohol induced…”
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Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity by Kobayashi, Akio, Kondo, Kazuma, Sugai, Shoichiro

“…Drug-induced liver injury is a main reason of regulatory action pertaining to drugs, including restrictions to clinical indications and withdrawal from the…”
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Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients by Kondo, Kazuma, Yamada, Naohito, Suzuki, Yusuke, Toyoda, Kaoru, Hashimoto, Tatsuji, Takahashi, Akemi, Kobayashi, Akio, Shoda, Toshiyuki, Kuno, Hideyuki, Sugai, Shoichiro

“…Acetaminophen (APAP) is a commonly used and effective analgesic and antipyretic agent. However, some patients encounter hepatotoxicity after repeated APAP…”
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Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats by Kobayashi, Akio, Suzuki, Yusuke, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are widely used as sensitive markers of possible tissue damage, particularly…”
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Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats by Kobayashi, Akio, Yokoyama, Hideaki, Kataoka, Jiro, Ishida, Tomio, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…Blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities are widely used as sensitive markers of liver toxicity. However, these…”
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Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions by Kobayashi, Akio, Oshida, Shin-ichi, Yamazaki, Yuji, Maekawa, Tatsuya, Kuno, Hideyuki, Sugai, Shoichiro, Sakakibara, Hiroyuki, Shimoi, Kayoko

“…In order to verify the nutritional aspect of alterations of the plasma and tissue transaminase activities, rats were fed 4 hr per day for 35 days (the…”
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臨床薬剤性肝障害リスク因子特定のためのバイオマーカーの探索：endogenous metabolite解析によるアセトアミノフェン誘発性肝障害に対する感受性予測 by 小林, 章男, 近藤, 千真, 菅井, 象一郎

“…「1. はじめに」 医薬品による薬剤性肝障害(drug induced liver injury; DILI)は, 規制当局による医薬品の適応制限や市場からの医薬品の撤退につながることがある重大な副作用の1つである. 製薬企業にとって開発化合物のDILI誘発性評価の精度を向上させることは,…”
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Effects of Delgocitinib Ointment 0.5% on the Normal Mouse Skin and Epidermal Tight Junction Proteins in Comparison With Topical Corticosteroids by Anagawa-Nakamura, Akiko, Ryoke, Katsunori, Yasui, Yuzo, Shoda, Toshiyuki, Sugai, Shoichiro

“…Delgocitinib ointment 0.5% is the world’s first topical Janus kinase inhibitor product and was approved for treatment of atopic dermatitis (AD) in Japan…”
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Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide‐induced hepatic steatosis in rats by Muta, Kyotaka, Saito, Kosuke, Kemmochi, Yusuke, Masuyama, Taku, Kobayashi, Akio, Saito, Yoshiro, Sugai, Shoichiro

“…Ethionamide (ETH), a second‐line drug for multidrug‐resistant tuberculosis, is known to cause hepatic steatosis in rats and humans. To investigate predictive…”
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URINARY EXCRETION OF OXIDATIVE METABOLITES OF BILIRUBIN IN FENOFIBRATE-TREATED RATS by KOBAYASHI, Akio, TAKAHASHI, Tadakazu, SUGAI, Shoichiro, MIYAKAWA, Yoshifumi, IWATSUKA, Hisashi, YAMAGUCHI, Tokio

“…Bilirubin oxidative metabolites (BOM) were shown to be excreted into the urine in rats in which exaggerated oxidative stress was induced. We measured bilirubin…”
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Arachidonic acid-containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen-induced hepatic phospholipidosis: AA-containing PC is a marker for tamoxifen PLD by Saito, Kosuke, Goda, Keisuke, Kobayashi, Akio, Yamada, Naohito, Maekawa, Kyoko, Saito, Yoshiro, Sugai, Shoichiro

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Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity by Kobayashi, Akio, Kondo, Kazuma, Sugai, Shoichiro

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