Search Results - "Sugahara, Kunio"

Differential Dose Response of mTOR Signaling to Oral Administration of Leucine in Skeletal Muscle and Liver of Rats by YOSHIZAWA, Fumiaki, MOCHIZUKI, Shinji, SUGAHARA, Kunio

“…Phosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1) in the rat liver increased in…”
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Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells by Tanemura, Shuhei, Seki, Noriyasu, Tsujimoto, Hideto, Saito, Shuntaro, Kikuchi, Jun, Sugahara, Kunio, Yoshimoto, Keiko, Suzuki, Katsuya, Kaneko, Yuko, Chiba, Kenji, Takeuchi, Tsutomu

“…Abstract Interleukin (IL)-21-producing T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic…”
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Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells by Tanemura, Shuhei, Tsujimoto, Hideto, Seki, Noriyasu, Kojima, Shinji, Miyoshi, Fumihiko, Sugahara, Kunio, Yoshimoto, Keiko, Suzuki, Katsuya, Kaneko, Yuko, Chiba, Kenji, Takeuchi, Tsutomu

“…Abstract T follicular helper (Tfh) cells and T peripheral helper (Tph) cells produce interleukin (IL)-21 and are thought to contribute to follicular and…”
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Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis by Doi, Masako, Yamaoka, Ippei, Nakayama, Mitsuo, Sugahara, Kunio, Yoshizawa, Fumiaki

“…Isoleucine, a branched chain amino acid, plays an important role in the improvement of glucose metabolism as evidenced by the increase of insulin-independent…”
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An Increase in Liver Polyamine Concentration Contributes to the Tryptophan-Induced Acute Stimulation of Rat Hepatic Protein Synthesis by Koike, Shinichiro, Kabuyama, Yukihito, Obeng, Kodwo Amuzuah, Sugahara, Kunio, Sato, Yusuke, Yoshizawa, Fumiaki

“…Tryptophan has a unique role as a nutritional signaling molecule that regulates protein synthesis in mouse and rat liver. However, the mechanism underlying the…”
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Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models by Kataoka, Hirotoshi, Oshita, Koichi, Kakimoto, Tetsuhiro, Takemoto, Kana, Mochiduki, Sachiko, Murase, Mikako, Shimano, Kyoko, Maeda, Yasuhiro, Sugahara, Kunio, Utsumi, Hiroyuki

“…Amiselimod (MT-1303) is a novel and selective sphingosine 1-phosphate receptor-1 (S1P1) modulator with a more favorable cardiac safety profile than other S1P1…”
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Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells by Shimano, Kyoko, Maeda, Yasuhiro, Kataoka, Hirotoshi, Murase, Mikako, Mochizuki, Sachiko, Utsumi, Hiroyuki, Oshita, Koichi, Sugahara, Kunio

“…Amiselimod (MT-1303) is a novel sphingosine 1-phosphate receptor-1 (S1P1 receptor) modulator with a more favorable cardiac safety profile than other S1P1…”
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Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow by Maeda, Yasuhiro, Seki, Noriyasu, Sato, Noriko, Sugahara, Kunio, Chiba, Kenji

“…Sphingosine 1-phosphate (S1P) and its receptor, S1P receptor type 1 (S1P1), are essential for lymphocyte egress from secondary lymphoid organs (SLO)…”
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S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1 by Maeda, Yasuhiro, Yagi, Hideki, Takemoto, Kana, Utsumi, Hiroyuki, Fukunari, Atsushi, Sugahara, Kunio, Masuko, Takashi, Chiba, Kenji

“…S1P lyase keeps S1P levels low in the perivascular spaces and promotes thymocyte egress Sphingosine 1-phosphate (S1P) and S1P receptor 1 (S1P1) play an…”
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Role of Sphingosine 1-Phosphate Receptor Type 1 in Lymphocyte Egress from Secondary Lymphoid Tissues and Thymus by Chiba, Kenji, Matsuyuki, Hirofumi, Maeda, Yasuhiro, Sugahara, Kunio

“…Circulation of mature lymphocytes between blood and secondary lymphoid tissues plays a central role in the immune system. Homing of lymphocytes from blood into…”
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FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration by Kataoka, Hirotoshi, Sugahara, Kunio, Shimano, Kyoko, Teshima, Koji, Koyama, Mamoru, Fukunari, Atsushi, Chiba, Kenji

“…FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating…”
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Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus by Seki, Noriyasu, Tsujimoto, Hideto, Tanemura, Shuhei, Kojima, Shinji, Miyoshi, Fumihiko, Kikuchi, Jun, Saito, Shuntaro, Akiyama, Mitsuhiro, Sugahara, Kunio, Yoshimoto, Keiko, Kaneko, Yuko, Chiba, Kenji, Takeuchi, Tsutomu

“…T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic role in autoimmune diseases. However, the…”
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Central administration of insulin suppresses food intake in chicks by Honda, Kazuhisa, Kamisoyama, Hiroshi, Saneyasu, Takaoki, Sugahara, Kunio, Hasegawa, Shin

“…Although the orexigenic action of peptide hormones such as ghrelin and growth hormone releasing peptide is different between chickens and mammals, the…”
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Local administration of l-DOPA in the chicken ventromedial hypothalamus increases dopamine release in a dose-dependent manner by Alam, Mohammad Rashedul, Yoshizawa, Fumiaki, Sugahara, Kunio

“…► In vivo microdialysis showed the effect of l-DOPA on extracellular DA levels in chick VMH. ► Extracellular DA levels increased significantly in the VMH after…”
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Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity by Doi, Masako, Yamaoka, Ippei, Nakayama, Mitsuo, Mochizuki, Shinji, Sugahara, Kunio, Yoshizawa, Fumiaki

“…Leucine and isoleucine were shown to stimulate insulin-independent glucose uptake in skeletal muscle cells in vitro. In this study, we examined the effects of…”
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The mechanism underlying the central glucagon-induced hyperglycemia and anorexia in chicks by Honda, Kazuhisa, Kamisoyama, Hiroshi, Uemura, Taku, Yanagi, Takashi, Saito, Noboru, Kurose, Yohei, Sugahara, Kunio, Katoh, Kazuo, Hasegawa, Shin

“…We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all…”
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L-DOPA induced extracellular dopamine increases in the ventromedial hypothalamus affects food intake by chickens on a lysine-free diet by Alam, Mohammad Rashedul, Yoshizawa, Fumiaki, Sugahara, Kunio

“…► Effect of L-DOPA on extracellular DA levels in the chick VMH was studied using microdialysis. ► Extracellular DA levels significantly increased in the VMH…”
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Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks by Kamisoyama, Hiroshi, Honda, Kazuhisa, Saneyasu, Takaoki, Sugahara, Kunio, Hasegawa, Shin

“…Proopiomelanocortin (POMC, a precursor of anorexigenic neuropeptides) neurons in hypothalamus suppresses food intake in both mammals and chickens. In mammals,…”
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Central administration of neuromedin U suppresses food intake in chicks by Kamisoyama, Hiroshi, Honda, Kazuhisa, Saneyasu, Takaoki, Sugahara, Kunio, Hasegawa, Shin

“…The appetite-suppressive action of brain–gut peptides is similar in both chickens and mammals. In mammals, the brain–gut peptide neuromedin U (NMU) suppresses…”
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Central administration of glucagon suppresses food intake in chicks by Honda, Kazuhisa, Kamisoyama, Hiroshi, Saito, Noboru, Kurose, Yohei, Sugahara, Kunio, Hasegawa, Shin

“…Food intake in chickens is regulated in a manner similar to that in mammals. Corticotropin-releasing factor (CRF), which increases the plasma corticosterone…”
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