Search Results - "Suess, Daniel L. M."

A Synthetic Model of Enzymatic [Fe4S4]–Alkyl Intermediates by Ye, Mengshan, Thompson, Niklas B, Brown, Alexandra C, Suess, Daniel L. M

“…Although alkyl complexes of [Fe4S4] clusters have been invoked as intermediates in a number of enzymatic reactions, obtaining a detailed understanding of their…”
Get full text

H–H and Si–H Bond Addition to FeNNR2 Intermediates Derived from N2 by Suess, Daniel L. M, Peters, Jonas C

“…The synthesis and characterization of Fe–diphosphineborane complexes are described in the context of N2 functionalization chemistry. Iron aminoimides can be…”
Get full text

X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly by Dinis, Pedro, Suess, Daniel L. M., Fox, Stephen J., Harmer, Jenny E., Driesener, Rebecca C., De La Paz, Liliana, Swartz, James R., Essex, Jonathan W., Britt, R. David, Roach, Peter L.

“…Hydrogenases use complex metal cofactors to catalyze the reversible formation of hydrogen. In [FeFe]-hydrogenases, the H-cluster cofactor includes a diiron…”
Get full text

Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster by McSkimming, Alex, Suess, Daniel L. M.

“…The Fe–S clusters of nitrogenases carry out the life-sustaining conversion of N 2 to NH 3 . Although progress continues to be made in modelling the structural…”
Get full text

Cysteine as a ligand platform in the biosynthesis of the FeFe hydrogenase H cluster by Suess, Daniel L. M., Bürstel, Ingmar, De La Paz, Liliana, Kuchenreuther, Jon M., Pham, Cindy C., Cramer, Stephen P., Swartz, James R., Britt, R. David

“…Hydrogenases catalyze the redox interconversion of protons and H2, an important reaction for a number of metabolic processes and for solar fuel production. In…”
Get full text

Selective Synthesis of Site-Differentiated Fe4S4 and Fe6S6 Clusters by McSkimming, Alex, Suess, Daniel L. M

“…Obtaining rational control over the structure and nuclearity of metalloclusters is an ongoing challenge in synthetic Fe–S cluster chemistry. We report a new…”
Get full text

Reversible Formation of Alkyl Radicals at [Fe4S4] Clusters and Its Implications for Selectivity in Radical SAM Enzymes by Brown, Alexandra C, Suess, Daniel L. M

“…All kingdoms of life use the transient 5′-deoxyadenosyl radical (5′-dAdo•) to initiate a wide range of difficult chemical reactions. Because of its high…”
Get full text

Controlling Substrate Binding to Fe4S4 Clusters through Remote Steric Effects by Brown, Alexandra C, Suess, Daniel L. M

“…The extraordinary reactivity exhibited by many Fe–S enzymes is due in large part to the influence of the protein scaffold on substrate binding and activation…”
Get full text

The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase by Span, Elise A, Suess, Daniel L. M, Deller, Marc C, Britt, R. David, Marletta, Michael A

“…Polysaccharide monooxygenases (PMOs) are secreted metalloenzymes that catalyze the oxidative degradation of polysaccharides in a copper-, oxygen-, and…”
Get full text

A Terminal Imido Complex of an Iron–Sulfur Cluster by Sridharan, Arun, Brown, Alexandra C., Suess, Daniel L. M.

“…We report the synthesis and characterization of the first terminal imido complex of an Fe–S cluster, (IMes)3Fe4S4=NDipp (2;…”
Get full text

A CO-Derived Iron Dicarbyne That Releases Olefin upon Hydrogenation by Suess, Daniel L. M, Peters, Jonas C

“…An iron diphosphineborane platform that was previously reported to facilitate a high degree of N2 functionalization is herein shown to effect reductive CO…”
Get full text

Connecting the geometric and electronic structures of the nitrogenase iron–molybdenum cofactor through site-selective 57Fe labelling by Badding, Edward D., Srisantitham, Suppachai, Lukoyanov, Dmitriy A., Hoffman, Brian M., Suess, Daniel L. M.

“…Understanding the chemical bonding in the catalytic cofactor of the Mo nitrogenase (FeMo-co) is foundational for building a mechanistic picture of biological…”
Get full text

Manganese–Cobalt Oxido Cubanes Relevant to Manganese-Doped Water Oxidation Catalysts by Nguyen, Andy I, Suess, Daniel L. M, Darago, Lucy E, Oyala, Paul H, Levine, Daniel S, Ziegler, Micah S, Britt, R. David, Tilley, T. Don

“…Incorporation of Mn into an established water oxidation catalyst based on a Co­(III)4O4 cubane was achieved by a simple and efficient assembly of permanganate,…”
Get full text

The HydG Enzyme Generates an Fe(CO)2(CN) Synthon in Assembly of the FeFe Hydrogenase H-Cluster by Kuchenreuther, Jon M., Myers, William K., Suess, Daniel L. M., Stich, Troy A., Pelmenschikov, Vladimir, Shiigi, Stacey A., Cramer, Stephen P., Swartz, James R., Britt, R. David, George, Simon J.

“…Three iron-sulfur proteins–HydE, HydF, and HydG–play a key role in the synthesis of the [2Fe]H component of the catalytic H-cluster of FeFe hydrogenase. The…”
Get full text

The Radical SAM Enzyme HydG Requires Cysteine and a Dangler Iron for Generating an Organometallic Precursor to the [FeFe]-Hydrogenase H‑Cluster by Suess, Daniel L. M, Pham, Cindy C, Bürstel, Ingmar, Swartz, James R, Cramer, Stephen P, Britt, R. David

“…Three maturase enzymesHydE, HydF, and HydGsynthesize and insert the organometallic component of the [FeFe]-hydrogenase active site (the H-cluster). HydG…”
Get full text

Biosynthesis of the [FeFe] Hydrogenase H Cluster: A Central Role for the Radical SAM Enzyme HydG by Suess, Daniel L. M, Kuchenreuther, Jon M, De La Paz, Liliana, Swartz, James R, Britt, R. David

“…Hydrogenase enzymes catalyze the rapid and reversible interconversion of H2 with protons and electrons. The active site of the [FeFe] hydrogenase is the H…”
Get full text

An Mn(V)–oxo role in splitting water? by Britt, R. David, Suess, Daniel L. M., Stich, Troy A.

Get full text

Free H2 Rotation vs Jahn–Teller Constraints in the Nonclassical Trigonal (TPB)Co–H2 Complex by Gunderson, William A, Suess, Daniel L. M, Fong, Henry, Wang, Xiaoping, Hoffmann, Christina M, Cutsail III, George E, Peters, Jonas C, Hoffman, Brian M

“…Proton exchange within the M–H2 moiety of (TPB)Co(H2) (Co–H2; TPB = B(o-C6H4P i Pr2)3) by 2-fold rotation about the M–H2 axis is probed through EPR/ENDOR…”
Get full text

An [Fe4S4]3+–Alkyl Cluster Stabilized by an Expanded Scorpionate Ligand by McSkimming, Alex, Sridharan, Arun, Thompson, Niklas B, Müller, Peter, Suess, Daniel L. M

“…Alkyl-ligated iron–sulfur clusters in the [Fe4S4]3+ charge state have been proposed as short-lived intermediates in a number of enzymatic reactions. To better…”
Get full text

Cluster-selective 57 Fe labeling of a Twitch-domain-containing radical SAM enzyme by Namkoong, Gil, Suess, Daniel L M

“…Fe-specific techniques such as Mössbauer spectroscopy are invaluable tools in mechanistic studies of Fe-S proteins. However, they remain underutilized for…”
Get full text