Search Results - "Suen, Hayley"

Isolation of Human CD138+ Microparticles from the Plasma of Patients with Multiple Myeloma by Krishnan, Sabna Rajeev, Luk, Frederick, Brown, Ross D, Suen, Hayley, Kwan, Yiulam, Bebawy, Mary

“…The confinement of multiple myeloma (MM) to the bone marrow microenvironment requires an invasive bone marrow biopsy to monitor the malignant compartment. The…”
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A liquid biopsy to detect multidrug resistance and disease burden in multiple myeloma by Rajeev Krishnan, Sabna, De Rubis, Gabriele, Suen, Hayley, Joshua, Douglas, Lam Kwan, Yiu, Bebawy, Mary

“…Multiple myeloma is an incurable cancer of bone marrow plasma cells, with a 5-year survival rate of 43%. Its incidence has increased by 126% since 1990…”
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Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma by Brown, Ross, Suen, Hayley, Favaloro, James, Yang, Shihong, Ho, P. Joy, Gibson, John, Joshua, Douglas

“…Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the…”
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Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma by Favaloro, James, Liyadipitiya, Tulita, Brown, Ross, Yang, Shihong, Suen, Hayley, Woodland, Narelle, Nassif, Najah, Hart, Derek, Fromm, Phillip, Weatherburn, Claire, Gibson, John, Ho, P. Joy, Joshua, Douglas

“…Abstract Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of cells that have been implicated as inhibitors of lymphopoiesis in patients…”
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The T cell in Myeloma by Joshua, Douglas, Suen, Hayley, Brown, Ross, Bryant, Christian, Ho, P Joy, Hart, Derek, Gibson, John

“…Abstract An active role for the immune system in controlling the malignant plasma cell clone in myeloma has been postulated for many years. The clinical states…”
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Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state by Favaloro, James, Brown, Ross, Aklilu, Esther, Yang, Shihong, Suen, Hayley, Hart, Derek, Fromm, Phillip, Gibson, John, Khoo, Liane, Ho, P. Joy, Joshua, Douglas

“…Abstract Discrepancies in the literature between regulatory T cell (Treg) and pro-inflammatory T helper 17 (Th17) numbers in multiple myeloma (MM) can be…”
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CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis by Brown, Ross, Kabani, Karieshma, Favaloro, James, Yang, Shihong, Ho, P. Joy, Gibson, John, Fromm, Phillip, Suen, Hayley, Woodland, Narelle, Nassif, Najah, Hart, Derek, Joshua, Douglas

“…The transfer of membrane proteins between cells during contact, known as trogocytosis, can create novel cells with a unique phenotype and altered function. We…”
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Isolation of Human CD138+ Microparticles from the Plasma of Patients with Multiple Myeloma1 by Krishnan, Sabna Rajeev, Luk, Frederick, Brown, Ross D, Suen, Hayley, Kwan, Yiulam, Bebawy, Mary

“…The confinement of multiple myeloma (MM) to the bone marrow microenvironment requires an invasive bone marrow biopsy to monitor the malignant compartment. The…”
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A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset by Bryant, Christian, Fromm, Phillip D, Kupresanin, Fiona, Clark, Georgina, Lee, Kenneth, Clarke, Candice, Silveira, Pablo A, Suen, Hayley, Brown, Ross, Newman, Elizabeth, Cunningham, Ilona, Ho, P Joy, Gibson, John, Bradstock, Kenneth, Joshua, Douglas, Hart, Derek NJ

“…Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses…”
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Characterisation of the Mechanisms of Tumour-Induced Dysfunction of Clonal T Cell Expansions in Multiple Myeloma by Suen, Hayley

“…Multiple myeloma is a cancer involving malignant plasma cells in the bone marrow. Despite advances in therapy, relapse is inevitable due to residual disease…”
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Protective Cytotoxic Clonal T-Cells in Myeloma Have the Characteristics of Telomere-Independent Senescence Rather Than an Exhausted or Anergic Phenotype: Implications for Immunotherapy by Suen, Hayley, Joshua, Douglas E, Brown, Ross D, Yang, Shihong, Barbaro, Pasquale Mario, Ho, P Joy, Gibson, John

“…Dysfunctional T-cells associated with human tumors can be identified utilizing multi-parameter flow cytometry and studied for intracellular signalling…”
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Phospho-Flow Cytometry Quantitation of STAT Signalling Checkpoints in Malignant and Non-Malignant Cells Identifies Patients Suitable for pSTAT3 and 5 Targeted Inhibitors by Brown, Ross D, Ho, P Joy, Joshua, Douglas E, Yang, Shihong, Bryant, Christian, Suen, Hayley, Weatherburn, Claire, Larsen, Stephen, Hart, Derek NJ, Gibson, John

“…Background IL-6 receptor/JAK/STAT is a major signalling pathway associated with pleiotropic functions including cell transformation and proliferation. STAT3,…”
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A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia by Hsu, Jennifer, Bryant, Christian, Fromm, Phillip, Papadimitrious, Michael, Orellana, Daniel, Suen, Hayley, Yang, Shihong, Weatherburn, Claire, Gasiorowski, Robin, Iland, Harry J, Brown, Ross D, Joshua, Douglas E, Ho, Phoebe Joy, Gibson, John, Clark, Georgina, Hart, Derek NJ

“…Many acute myeloid leukemia (AML) patients achieve a complete remission (CR) with chemotherapy but relapse is common. Removal of residual disease remains the…”
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Blockade of the Hedgehog Signaling Pathway by the Novel Agent NVP-LDE225 Induces Differentiation, Prevents De-Differentiation and Inhibits Proliferation of Multiple Myeloma Stem Cells in Vitro by Yang, Shihong, Brown, Ross D, Loh, Yen S, Suen, Hayley, Favaloro, James, Gibson, John, Ho, Phoebe Joy, Joshua, Douglas E

“…Abstract 3950 Chemotherapy-resistant cancer stem cells are a major cause of relapse. It is considered that the small population of CD38++ cells which also…”
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Using digital polymerase chain reaction to detect minimal residual disease in myeloma by identifying FGFR3 up-regulation by McAuliffe, Simon, Brown, Ross, Catalano, Alberto, Ho, P. Joy, Nassif, Najah, Woodland, Narelle, Hart, Derek, Weatherburn, Claire, Yang, Shihong, Suen, Hayley, Paul, Cheryl, Joshua, Douglas, Gibson, John

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Ten Year Survival in Patients with Myeloma Is Characterized by the Persistence of Immunological Control Which Is Detected by Immunological Biomarkers by Brown, Ross D, Suen, Hayley, Bryant, Christian E, Yang, Shihong, Favaloro, James, Gibson, John, Ho, P Joy, Fromm, Phillip, Hart, Derek NJ, Joshua, Douglas E

“…Abstract 1818 There is clinical evidence for the presence of a limited degree of host-tumor control in patients with multiple myeloma (MM) but the exact…”
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Ten Year Survivors of Multiple Myeloma Demonstrate a Differential Expression of Immunological Biomarkers Including a High Incidence of Cytotoxic T-Cell Clones Which Have Not Acquired Myeloma-Associated Anergy by Bryant, Christian E, Brown, Ross D, Yang, Shihong, Suen, Hayley, Aklilu, Esther, Favaloro, James, Hart, Derek NJ, Fromm, Phillip, Woodland, Narelle, Nassif, Najah, Iland, Harry, Gibson, John, Ho, P Joy, Joshua, Douglas E

“…Abstract 3924▪▪This icon denotes a clinically relevant abstract Prior to the introduction of novel therapies for patients with multiple myeloma (MM) few…”
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