Search Results - "Sue, Mayumi"

Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates by Sue, Mayumi, Tsubaki, Takuya, Ishimoto, Yoko, Hayashi, Shinko, Ishida, Saori, Otsuka, Takafumi, Isumi, Yoshitaka, Kawase, Yumi, Yamaguchi, Junko, Nakada, Takashi, Ishiguro, Jun, Nakamura, Kensuke, Kawaida, Reimi, Ohtsuka, Toshiaki, Wada, Teiji, Agatsuma, Toshinori, Kawasaki, Norihito

“…Signal regulatory protein alpha (SIRPα) is an immune inhibitory receptor on myeloid cells including macrophages and dendritic cells, which binds to CD47, a…”
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Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices by Higashi, Nobuaki, Waki, Michihiko, Sue, Mayumi, Kogane, Yusuke, Shida, Hiroaki, Tsunekawa, Naoki, Hasan, Ahasanul, Sato, Takeshi, Kitahara, Ayumi, Kasaoka, Tatsuhiko, Hayakawa, Yoshihiro, Nakajima, Motowo, Irimura, Tatsuro

“…Heparanase cleaves macromolecular heparin in the secretory granules of connective tissue-type mast cells. We investigated roles of the cleavage under a…”
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Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies by Komatsu, Noriko, Waki, Michihiko, Sue, Mayumi, Tokuda, Chikashi, Kasaoka, Tatsuhiko, Nakajima, Motowo, Higashi, Nobuaki, Irimura, Tatsuro

“…Degradation of extracellular matrix is associated with extravasation of metastatic tumor cells and inflammatory cells. Heparanase, the heparan sulfate-specific…”
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Blockade of SIRP[alpha]-CD47 axis by anti-SIRP[alpha] antibody enhances anti-tumor activity of DXd antibody-drug conjugates by Sue, Mayumi, Tsubaki, Takuya, Ishimoto, Yoko, Hayashi, Shinko, Ishida, Saori, Otsuka, Takafumi, Isumi, Yoshitaka, Kawase, Yumi, Yamaguchi, Junko, Nakada, Takashi, Ishiguro, Jun, Nakamura, Kensuke, Kawaida, Reimi, Ohtsuka, Toshiaki, Wada, Teiji, Agatsuma, Toshinori, Kawasaki, Norihito

“…Signal regulatory protein alpha (SIRP[alpha]) is an immune inhibitory receptor on myeloid cells including macrophages and dendritic cells, which binds to CD47,…”
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Novel anti-EPHA2 antibody, DS-8895a for cancer treatment by Hasegawa, Jun, Sue, Mayumi, Yamato, Michiko, Ichikawa, Junya, Ishida, Saori, Shibutani, Tomoko, Kitamura, Michiko, Wada, Teiji, Agatsuma, Toshinori

“…Overexpression of EPHA2 has been observed in multiple cancers and reported to be associated with poor prognosis. Here, we produced an afucosylated humanized…”
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Development of a quantitative systems pharmacology (QSP) model to support dose optimization of DS-1103a (anti SIRPa antibody) in combination with trastuzumab deruxtecan in patients with cancer by Cheng, Yougan, Vuppala, Pradeep, Sarma, Uddipan, Chelliah, Viji, Graaf, Piet van der, Karibe, Tsuyoshi, Hayashi, Shinko, Tsubaki, Takuya, Kawasaki, Norihito, Ishimoto, Yoko, Herrmann, Monika, Sue, Mayumi, Mires, Derek E., Toso, John F., Lau, Yvonne Y., Leil, Tarek

“…e14509 Background: DS-1103a, an anti-human signal regulatory protein α (SIRPα) monoclonal antibody (mAb), is designed to block the SIRPα-CD47 axis “Don’t Eat…”
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An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches by Sue, Mayumi, Higashi, Nobuaki, Shida, Hiroaki, Kogane, Yusuke, Nishimura, Yoshio, Adachi, Hayamitsu, Kolaczkowska, Elzbieta, Kepka, Magdalena, Nakajima, Motowo, Irimura, Tatsuro

“…Local infiltration of inflammatory cells is regulated by a number of biological steps during which the cells likely penetrate through subendothelial basement…”
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