Search Results - "Sudo, RT"

In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats by Raimundo, Juliana Montani, Sudo, Roberto Takashi, Pontes, Luana Braga, Antunes, Fernanda, Trachez, Margarete Manhães, Zapata-Sudo, Gisele

“…Tramadol ((±)-tramadol) is an analgesic agent formulated as a racemic mixture (1 : 1) of (−)- and (+)-tramadol, which differ in their potency to bind to…”
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Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain by Vieira, Marcio Carneiro, Monte, Fernanda Bezerra de Mello, Eduardo Dematte, Bruno, Montagnoli, Tadeu Lima, Montes, Guilherme Carneiro, da Silva, Jaqueline Soares, Mendez-Otero, Rosalia, Trachez, Margarete Manhães, Sudo, Roberto Takashi, Zapata-Sudo, Gisele

“…New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli…”
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Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues by Silva, Alexandre G., Zapata-Sudo, Gisele, Kummerle, Arthur E., Fraga, Carlos A.M., Barreiro, Eliezer J., Sudo, Roberto T.

“…New derivatives of LASSBio-294 were designed and tested on the contractile response of vascular smooth muscle from Wistar rats. LASSBio-785 (IC 50 = 10.2 μM)…”
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New Benzofuran N -Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis by Costa, Gizele Cabral, Montagnoli, Tadeu Lima, Da Silva, Jaqueline Soares, de Alencar, Allan Kardec Nogueira, Reina Gamba, Luis Eduardo, Alves, Bryelle Eccard Oliveira, da Silva, Marina Moraes Carvalho, Trachez, Margarete Manhães, do Nascimento, José Hamilton M, Pimentel-Coelho, Pedro Moreno, Mendez-Otero, Rosália, Lima, Lidia Moreira, Barreiro, Eliezer J, Sudo, Roberto Takashi, Zapata-Sudo, Gisele

“…Diabetic obese patients are susceptible to the development of cardiovascular disease, including hypertension and cardiac dysfunction culminating in diabetic…”
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Novel agonist of α4β2 neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain by Sudo, Roberto T, Hayashida, Kenichiro, Santos, Aluízio N, Kawatani, Masahito, Carlos ES Monteiro, Moreira, Roberto D, Trachez, Margarete M, Montes, Guilherme C, Zapata-Sudo, Gisele

“…Objective: To demonstrate the antinociceptive and antihypersensitivity mechanisms of Cris-104 (1-{2-[5-(4-fluorophenyl)–1H-pyrazol-4-yl]ethyl}piperidine), a…”
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Adenosine A2Areceptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction by da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JHM, Fraga CAM, Barreiro EJ, Zapata-Sudo G

“…Jaqueline S da Silva,1 Daniele Gabriel-Costa,1 Roberto T Sudo,1 Hao Wang,2 Leanne Groban,2 Emanuele B Ferraz,3 José Hamilton M Nascimento,3 Carlos Alberto M…”
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The Synergistic Interaction Between Morphine and Maprotiline After Intrathecal Injection in Rats by Pettersen, Vera L. A., Zapata-Sudo, Gisele, Raimundo, Juliana M., Trachez, Margarete M., Sudo, Roberto T.

“…Antidepressant drugs act as potent inhibitors of norepinephrine and/or serotonin reuptake and are widely used with opioids for the treatment of chronic pain…”
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Synthesis, solubility, plasma stability, and pharmacological evaluation of novel sulfonylhydrazones designed as anti-diabetic agents by Zapata-Sudo, Gisele, da Costa Nunes, Isabelle Karine, Araujo, Josenildo Segundo Chaves, da Silva, Jaqueline Soares, Trachez, Margarete Manhães, da Silva, Tiago Fernandes, da Costa, Filipe P, Sudo, Roberto Takashi, Barreiro, Eliezer J, Lima, Lídia Moreira

“…Neuropathy is a serious complication of diabetes that has a significant socioeconomic impact, since it frequently demands high levels of health care…”
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Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives with in vivo hypnotic and analgesic profile by Menegatti, Ricardo, Silva, Gilberto M.S., Zapata-Sudo, Gisele, Raimundo, Juliana M., Sudo, Roberto T., Barreiro, Eliezer J., Fraga, Carlos A.M.

“…The new powerful central-acting heterotricyclic analgesic agent LASSBio-873 ( 5) is reported. The present study describes the synthesis and pharmacological…”
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Hypoglycemic effect of the methanol flower extract of piper claussenianum and the major constituent 2′,6′-dihydroxy-4′-methoxychalcone in streptozotocin diabetic rats by Marques, A, Pereira, S, Paiva, R, Cavalcante, C, Sudo, S, Tinoco, l, Moreira, D, Guimaraes, E, Sudo, R, Kaplan, MAC, Sudo, G

“…Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels…”
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Dexmedetomidine prolongs spinal anaesthesia induced by levobupivacaine 0.5% in guinea-pigs by Calasans-Maia, Jorge A., Zapata-Sudo, Gisele, Sudo, Roberto T.

“…Alpha‐2 adrenoceptor agonists have been used in association with local anaesthetic to increase the duration of spinal anaesthesia. Intrathecal administration…”
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COMPARATIVE EFFECTS OF TRAMADOL ON VASCULAR REACTIVITY IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS by Raimundo, Juliana M, Pontes, Luana B, Antunes, Fernanda, Sudo, Roberto T, Trachez, Margarete M, Zapata-Sudo, Gisele

“…SUMMARY 1 The aim of the present study was to determine the effects of tramadol on vascular reactivity in aortic rings from Wistar‐Kyoto (WKY) rats and…”
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The new compound, LASSBio 294, increases the contractility of intact and saponin‐skinned cardiac muscle from Wistar rats by Sudo, R T, Zapata‐Sudo, G, Barreiro, E J

“…A new compound designated as LASSBio 294 (L‐294), 3,4‐methylenedioxybenzoyl‐2‐thienylhydrazone, was synthesized as an alternative therapeutic for cardiac…”
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Is comparative cardiotoxicity of S(-) and R(+) bupivacaine related to enantiomer-selective inhibition of L-type Ca2+ channels? by ZAPATA-SUDO, Gisele, TRACHEZ, Margarete M, SUDO, Roberto T, NELSON, Thomas E

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ACTIVITY OF CECROPIA LYRATILOBA EXTRACT ON CONTRACTILITY OF CARDIAC AND SMOOTH MUSCLES IN WISTAR RATS by Ramos Almeida, Roberta, Montani Raimundo, Juliana, Rodrigues Oliveira, Rodrigo, Coelho Kaplan, Maria Auxiliadora, Rocah Gattass, Cerli, Sudo, Roberto Takashi, Zapata-Sudo, Gisele

“…SUMMARY 1 Brazilian forests show high diversity of medicinal plants and several are used in folk medicine for the treatment of hypertension and asthma. The aim…”
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Regulation of Intracellular Calcium by Bupivacaine Isomers in Cardiac Myocytes from Wistar Rats by Chedid, Núbia G. B., Sudo, Roberto T., Aguiar, Marli I. S., Trachez, Margarete M., Masuda, Masako O., Zapata-Sudo, Gisele

“…In this study we investigated the effects of a racemic mixture of bupivacaine (RS(±)bupivacaine) and its isomers (S(-)bupivacaine and R(+)bupivacaine) on the…”
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Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel : Clinical implications by NELSON, T. E, LIN, M, ZAPATA-SUDO, G, TAKASHI SUDO, R

“…Dantrolene sodium (DS) is a direct-acting skeletal muscle relaxant whose only known action is to block calcium release from intracellular storage sites. The…”
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Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain by Sudo, Roberto T, Neto, Miguel L, Monteiro, Carlos E S, Amaral, Rachel V, Resende, Ângela C, Souza, Pergentino J C, Zapata-Sudo, Gisele, Moura, Roberto S

“…Plants rich in flavonoids, such as açaí (Euterpe oleraceae Mart.), can induce antinociception in experimental animals. Here, we tested an extract obtained from…”
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Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats by Trachez, M. M., Zapata-Sudo, G., Moreira, O. R., Chedid, N. G. B., Russo, V. F. T., Russo, E. M. S., Sudo, R. T.

“…Background:  Racemic [RS(±)] bupivacaine can be associated with severe cardiotoxicity. The S(–) isomer is known to be less neuro‐ and cardiotoxic, but…”
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Thienylhydrazone derivative increases sarcoplasmic reticulum Ca2+ release in mammalian skeletal muscle by ZAPATA-SUDO, Gisele, SUDO, Roberto T, MARONAS, Patricia A, SILVA, Gisele L. M, MOREIRA, Orlando R, AGUIAR, Marli I. S, BARREIRO, Eliezer J

“…3,4-Methylenedioxybenzoyl-2-thienylhydrazone (L-294) is a cardiac inotropic drug whose action is mediated by an increase in intracellular Ca(2+) concentration…”
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