Search Results - "Sudo, R. T."

The new compound, LASSBio 294, increases the contractility of intact and saponin‐skinned cardiac muscle from Wistar rats by Sudo, R T, Zapata‐Sudo, G, Barreiro, E J

“…A new compound designated as LASSBio 294 (L‐294), 3,4‐methylenedioxybenzoyl‐2‐thienylhydrazone, was synthesized as an alternative therapeutic for cardiac…”
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Hypoglycemic effect of the methanol flower extract of piper claussenianum and the major constituent 2′,6′-dihydroxy-4′-methoxychalcone in streptozotocin diabetic rats by Marques, A, Pereira, S, Paiva, R, Cavalcante, C, Sudo, S, Tinoco, l, Moreira, D, Guimaraes, E, Sudo, R, Kaplan, MAC, Sudo, G

“…Piper claussenianum inflorescences crude methanol extract was tested for hypoglycemic effect in streptozotocin-induced diabetic rats. The blood glucose levels…”
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Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats by Trachez, M. M., Zapata-Sudo, G., Moreira, O. R., Chedid, N. G. B., Russo, V. F. T., Russo, E. M. S., Sudo, R. T.

“…Background:  Racemic [RS(±)] bupivacaine can be associated with severe cardiotoxicity. The S(–) isomer is known to be less neuro‐ and cardiotoxic, but…”
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Novel skeletal muscle ryanodine receptor mutation in a large Brazilian family with malignant hyperthermia by McWilliams, S, Nelson, T, Sudo, RT, Zapata-Sudo, G, Batti, M, Sambuughin, N

“…Malignant hyperthermia (MH) is an autosomal dominant disorder that predisposes susceptible individuals to a potentially life‐threatening crisis when exposed to…”
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Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells by Zaloga, G P, Roberts, P R, Black, K W, Lin, M, Zapata-Sudo, G, Sudo, R T, Nelson, T E

“…Myocardial contractile failure is a common cause of morbidity and mortality in patients with ischemic heart disease and systemic inflammatory states such as…”
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Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice by Silva, G A P, Kummerle, A E, Antunes, F, Fraga, C A M, Barreiro, E J, Zapata-Sudo, G, Sudo, R T

“…The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786)…”
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Intravenous administration of azumolene to reverse malignant hyperthermia in swine by Carmo, P.L. do, Zapata-Sudo, G, Trachez, M.M, Antunes, F, Guimaraes, S.E.F, Debom, R, Rizzi, M.D.R, Sudo, R.T

“…Background: The efficacy of intravenous (IV) administration of azumolene (Az), an analogue 30-fold more soluble than dantrolene, on pigs susceptible to…”
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Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene by Matos, A R, Sambuughin, N, Rumjanek, F D, Amoedo, N D, Cunha, L B P, Zapata-Sudo, G, Sudo, R T

“…Malignant hyperthermia (MH) is a pharmacogenetic disease triggered in susceptible individuals by the administration of volatile halogenated anesthetics and/or…”
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Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil by Sudo, R T, Cunha, L B P, Carmo, P L, Matos, A R, Trachez, M M, Cardoso, L A M, Aguiar, M I S, Abreu, A V, Zapata-Sudo, G

“…Malignant hyperthermia (MH) is a pharmacogenetic disease triggered by volatile anesthetics and succinylcholine. Deaths due to MH have been reported in Brazil…”
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Effects of Chronic Intraventricular Sodium on Blood Pressure and Fluid Balance by Kawano, Yuhei, Sudo, R Takashi, Ferrario, Carlos

“…To examine if chronic sodium loading on the brain produces sustained increases in blood pressure, water intake, and sodium excretion, hypertonic (0.5 M and 1.5…”
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Alterations in the functional properties of skinned fibers from denervated rabbit skeletal muscle by Trachez, M M, Sudo, R T, Suarez-Kurtz, G

“…Isometric tension was recorded in vitro from chemically skinned fibers obtained from normal and 14-day-denervated extensor digitorum longus muscles of the…”
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Halothane cooling contractures of skinned mammalian muscle fibers by SUDO, R. T, ZAPATA-SUDO, G, SUAREZ-KURTZ, G

“…The effects of halothane or cooling on Ca2(+)-activated tensions and on the uptake and release of Ca2+ by the sarcoplasmic reticulum were investigated in…”
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Pharmacokinetics of oral ciprofloxacin in healthy, young Brazilian subjects by Sudo, R T, Melo, P A, Suarez-Kurtz, G

“…1. The pharmacokinetics of ciprofloxacin were determined in 8 healthy young volunteers (5 men and 3 women) after administration of single oral doses of 250 mg…”
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Halothane-cooling contractures of mammalian muscles by Sudo, R T, Souza, M R, Zapata, G, Suarez-Kurtz, G

“…Mouse soleus and extensor digitorum longus muscles exposed to halothane concentrations (0.3-2.0%) that, at room temperature, have no effect on either resting…”
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Comparative pharmacokinetics of different oral nifedipine preparations in healthy Brazilian volunteers by Vianna-Jorge, R, Sudo, R T, Melo, P A, Suarez-Kurtz, G

“…1. The pharmacokinetics of different pharmaceutical preparations of oral nifedipine--Adalat (capsule), Oxcord and Cardalin (tablets)--was determined after…”
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In vitro and in vivo vasodilator activity of racemic tramadol and its enantiomers in Wistar rats by Raimundo, Juliana Montani, Sudo, Roberto Takashi, Pontes, Luana Braga, Antunes, Fernanda, Trachez, Margarete Manhães, Zapata-Sudo, Gisele

“…Tramadol ((±)-tramadol) is an analgesic agent formulated as a racemic mixture (1 : 1) of (−)- and (+)-tramadol, which differ in their potency to bind to…”
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Dantrolene sodium can increase or attenuate activity of skeletal muscle ryanodine receptor calcium release channel : Clinical implications by NELSON, T. E, LIN, M, ZAPATA-SUDO, G, TAKASHI SUDO, R

“…Dantrolene sodium (DS) is a direct-acting skeletal muscle relaxant whose only known action is to block calcium release from intracellular storage sites. The…”
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Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation by Montes, Guilherme Carneiro, Hammes, Nathalia, da Rocha, Miguel Divino, Montagnoli, Tadeu Lima, Fraga, Carlos Alberto Manssour, Barreiro, Eliezer J, Sudo, Roberto Takashi, Zapata-Sudo, Gisele

“…Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays an important role in its pathophysiology. In vitro,…”
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The temperature dependence of halothane-induced contractures of skeletal muscle by Suarez-Kurtz, G, Sudo, R T

“…Frog muscles bathed in solutions equilibrated with 0.5%-2.0% halothane develop large contractures when cooled to 2-4 degrees C. These halothane-cooling…”
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Potentiation of the halothane-cooling contractures of mammalian muscles by denervation by Trachez, M M, Sudo, R T, Suarez-Kurtz, G

“…Denervation potentiated the cooling-induced contractures and the halothane-cooling contractures of isolated extensor digitorum longus and soleus muscles of the…”
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