Search Results - "Sudhakar, Digumarthi V.S."
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Conformational scanning of individual EF-hand motifs of calcium sensor protein centrin-1
Published in Biochemical and biophysical research communications (17-09-2021)“…Centrin-1, a Ca2+ sensor protein of the centrin family is a crucial player for cell division in eukaryotes and plays a key role in the microtubule organising…”
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Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility
Published in Human molecular genetics (27-01-2023)“…Human spermatogenesis requires an orchestrated expression of numerous genes in various germ cell subtypes. Therefore, the genetic landscape of male infertility…”
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Genetics of male infertility - Present and future: A narrative review
Published in Journal of human reproductive sciences (01-07-2021)“…Infertility affects 8%-12% of couples worldwide with a male factor contributing to nearly 50% of couples either as a primary or contributing cause. Several…”
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Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility
Published in Scientific reports (11-09-2017)“…Prostate specific antigen (PSA/KLK3) is known to be the chief executor of the fragmentation of semenogelins, dissolution of semen coagulum, thereby releasing…”
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Genotype-Phenotype Study of the Middle Gangetic Plain in India Shows Association of rs2470102 with Skin Pigmentation
Published in Journal of investigative dermatology (01-03-2017)“…Our understanding of the genetics of skin pigmentation has been largely skewed towards populations of European ancestry, imparting less attention to South…”
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Optimization of purification method and characterization of recombinant human Centrin-1
Published in Protein expression and purification (01-08-2016)“…Centrins are acidic proteins, present in all eukaryotes to perform imperative roles in centrosome positioning and segregation. Existing methods for the…”
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IL10 Variant g.5311A Is Associated with Visceral Leishmaniasis in Indian Population
Published in PloS one (05-05-2015)“…Visceral leishmaniasis (VL) is a multifactorial disease, where the host genetics play a significant role in determining the disease outcome. The immunological…”
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