Search Results - "Sudhakar, Akulapalli"

Retraction Note: Inhibition of Tumor Angiogenesis by Tumstatin: Insights into Signaling Mechanisms and Implications in Cancer Regression by Sudhakar, Akulapalli, Boosani, Chandra S.

“…A Retraction Note to this paper has been published: https://doi.org/10.1007/s11095-020-02974-x…”
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Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing by Patil, Rohan, Das, Suranjana, Stanley, Ashley, Yadav, Lumbani, Sudhakar, Akulapalli, Varma, Ashok K

“…Weak intermolecular interactions such as hydrogen bonding and hydrophobic interactions are key players in stabilizing energetically-favored ligands, in an open…”
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Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria by Sugimoto, Hikaru, Hamano, Yuki, Charytan, David, Cosgrove, Dominic, Kieran, Mark, Sudhakar, Akulapalli, Kalluri, Raghu

“…There are about 2.5 million glomeruli in the kidneys each consisting of a barrel of glomerular basement membrane surrounded by glomerular endothelial cells on…”
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Differential Protein Expression Profiling by iTRAQ−2DLC−MS/MS of Lung Cancer Cells Undergoing Epithelial-Mesenchymal Transition Reveals a Migratory/Invasive Phenotype by Keshamouni, Venkateshwar G, Michailidis, George, Grasso, Catherine S, Anthwal, Shalini, Strahler, John R, Walker, Angela, Arenberg, Douglas A, Reddy, Raju C, Akulapalli, Sudhakar, Thannickal, Victor J, Standiford, Theodore J, Andrews, Philip C, Omenn, Gilbert S

“…Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) of epithelial cells in both normal embryonic development and certain…”
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Characterization of the anti-angiogenic properties of arresten, an α1β1 integrin-dependent collagen-derived tumor suppressor by Nyberg, Pia, Xie, Liang, Sugimoto, Hikaru, Colorado, Pablo, Sund, Malin, Holthaus, Kathryn, Sudhakar, Akulapalli, Salo, Tuula, Kalluri, Raghu

“…Physiological and pathological turnover of basement membranes liberates biologically active cryptic molecules. Several collagen-derived fragments possess…”
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Function of Endogenous Inhibitors of Angiogenesis as Endothelium-Specific Tumor Suppressors by Sund, Malin, Hamano, Yuki, Sugimoto, Hikaru, Sudhakar, Akulapalli, Soubasakos, Mary, Yerramalla, Udaya, Benjamin, Laura E., Lawler, Jack, Kieran, Mark, Shah, Amish, Kalluri, Raghu, Folkman, Judah

“…Disruption of the systemic angiogenesis balance to favor enhanced angiogenesis is speculated to represent a key step in the growth of tumors. Although a major…”
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Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis by Maeshima, Yohei, Sudhakar, Akulapalli, Lively, Julie C., Ueki, Kohjiro, Kharbanda, Surender, Kahn, C. Ronald, Sonenberg, Nahum, Hynes, Richard O., Kalluri, Raghu

“…Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic and proapoptotic activity. Here we show that tumstatin functions…”
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NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele by Tsukaguchi, Hiroyasu, Sudhakar, Akulapalli, Le, Tu Cam, Nguyen, Trang, Yao, Jun, Schwimmer, Joshua A, Schachter, Asher D, Poch, Esteban, Abreu, Patricia F, Appel, Gerald B, Pereira, Aparecido B, Kalluri, Raghu, Pollak, Martin R

“…Mutations in NPHS2, encoding podocin, have been identified in childhood onset focal and segmental glomerulosclerosis (FSGS). The role of NPHS2 in adult disease…”
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RETRACTED ARTICLE: Inhibition of Tumor Angiogenesis by Tumstatin: Insights into Signaling Mechanisms and Implications in Cancer Regression by Sudhakar, Akulapalli, Boosani, Chandra S.

“…Growing tumors develop additional new blood vessels to meet the demand for adequate nutrients and oxygen, a process called angiogenesis. Cancer is a highly…”
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Regulation of COX-2–mediated signaling by α3 type IV noncollagenous domain in tumor angiogenesis by Boosani, Chandra Shekhar, Mannam, Arjuna P., Cosgrove, Dominic, Silva, Rita, Hodivala-Dilke, Kairbaan M., Keshamouni, Venkateshwar G., Sudhakar, Akulapalli

“…Human α3 chain, a noncollagenous domain of type IV collagen [α3(IV)NC1], inhibits angiogenesis and tumor growth. These biologic functions are partly attributed…”
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Determinants of Vascular Permeability in the Kidney Glomerulus by Hamano, Yuki, Grunkemeyer, James A, Sudhakar, Akulapalli, Zeisberg, Michael, Cosgrove, Dominic, Morello, Roy, Lee, Brendan, Sugimoto, Hikaru, Kalluri, Raghu

“…The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma…”
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RETRACTED ARTICLE: Inhibitory Effects of Arresten on bFGF-Induced Proliferation, Migration, and Matrix Metalloproteinase-2 Activation in Mouse Retinal Endothelial Cells by Boosani, Chandra Shekar, Nalabothula, Narasimharao, Sheibani, Nader, Sudhakar, Akulapalli

“…This article has been retracted…”
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Molecular Cloning and Functional Characterization of Mouse α3(IV)NC1 by Boosani, Chandra Shekhar, Sudhakar, Akulapalli

“…Chandra Shekhar Boosani1 and Akulapalli Sudhakar1,2,3 1Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research…”
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Signaling Mechanisms of Endogenous Angiogenesis Inhibitors Derived from Type IV Collagen by Sudhakar, Akulapalli, Boosani, Chandra S.

“…Akulapalli Sudhakar1,2,3 and Chandra S. Boosani1 1Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research…”
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Human Tumstatin and Human Endostatin Exhibit Distinct Antiangiogenic Activities Mediated by αvβ3 and α5β1 Integrins by Sudhakar, Akulapalli, Sugimoto, Hikaru, Yang, Changqing, Lively, Julie, Zeisberg, Michael, Kalluri, Raghu

“…Tumstatin and endostatin are two inhibitors of angiogenesis derived from precursor human collagen molecules known as α3 chain of type IV collagen and α1 chain…”
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Retraction: Human [alpha]1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by [alpha]1[beta]1 integrin by Sudhakar, Akulapalli, Nyberg, Pia, Keshamouni, Venkateshwar G, Mannam, Arjuna P, Li, Jian, Sugimoto, Hikaru, Cosgrove, Dominic, Kalluri, Raghu

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Inhibition of Tumor Angiogenesis by Tumstatin : Insights into Signaling Mechanisms and Implications in Cancer Regression by SUDHAKAR, Akulapalli, BOOSANI, Chandra S

“…Growing tumors develop additional new blood vessels to meet the demand for adequate nutrients and oxygen, a process called angiogenesis. Cancer is a highly…”
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Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin by Hamano, Yuki, Zeisberg, Michael, Sugimoto, Hikaru, Lively, Julie C, Maeshima, Yohei, Yang, Changqing, Hynes, Richard O, Werb, Zena, Sudhakar, Akulapalli, Kalluri, Raghu

“…We demonstrate a physiological role for tumstatin, a cleavage fragment of the α3 chain of type IV collagen (Col IVα3), which is present in the circulation…”
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Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin by Sudhakar, Akulapalli, Nyberg, Pia, Keshamouni, Venkateshwar G, Mannam, Arjuna P, Li, Jian, Sugimoto, Hikaru, Cosgrove, Dominic, Kalluri, Raghu

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Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin by Sudhakar, Akulapalli, Nyberg, Pia, Keshamouni, Venkateshwar G., Mannam, Arjuna P., Li, Jian, Sugimoto, Hikaru, Cosgrove, Dominic, Kalluri, Raghu

“…Human noncollagenous domain 1 of the α1 chain of type IV collagen [α1(IV)NC1], or arresten, is derived from the carboxy terminal of type IV collagen. It was…”
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