Search Results - "Suddason, Tesha"

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes by Evans, Hayley G, Suddason, Tesha, Jackson, Ian, Taams, Leonie S, Lord, Graham M

“…Recently, a new lineage of CD4⁺ T cells has been described in the mouse that specifically secretes IL-17 [T helper (Th) 17]. This discovery has led to a…”
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T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion by Suddason, Tesha, Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen

“…MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in…”
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MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival by Steed, Emily, Elbediwy, Ahmed, Vacca, Barbara, Dupasquier, Sébastien, Hemkemeyer, Sandra A, Suddason, Tesha, Costa, Ana C, Beaudry, Jean-Bernard, Zihni, Ceniz, Gallagher, Ewen, Pierreux, Christophe E, Balda, Maria S, Matter, Karl

“…MarvelD3 is a transmembrane component of tight junctions, but there is little evidence for a direct involvement in the junctional permeability barrier. Tight…”
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Genetic insights into Map3k-dependent proliferative expansion of T cells by Suddason, Tesha, Gallagher, Ewen

“…Mapks are important regulators of T cell proliferative expansion and cell cycle progression. Detailed genetic analysis of unconventional iNKT cells in both…”
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Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells by Vantourout, Pierre, Kemper, Claudia, Hayday, Adrian, Le Friec, Gaelle, Cardone, John, Jackson, Ian, Atkinson, John P, Suddason, Tesha, Cope, Andrew, Lord, Graham, Fuchs, Anja, Roberts, Andrew

“…CD46 is best known as a regulator of complement function. Kemper et al . show that CD46 can switch inflammatory T cells into a regulatory mode and demonstrate…”
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The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines by Charlaftis, Nikolaos, Suddason, Tesha, Wu, Xuefeng, Anwar, Saba, Karin, Michael, Gallagher, Ewen

“…Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1 ) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse…”
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Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice by Lopes, Douglas M., Denk, Franziska, Chisholm, Kim I., Suddason, Tesha, Durrieux, Camille, Thakur, Matthew, Gentry, Clive, McMahon, Stephen B.

“…The immune and sensory systems are known for their close proximity and interaction. Indeed, in a variety of pain states, a myriad of different immune cells are…”
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The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling by Gallagher, Ewen, Suddason, Tesha

“…We generated a mutation in the gene encoding mitogen-activated protein kinase kinase kinase 1 (Map3k1) that results in a protein with an inactive plant…”
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The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines by Charlaftis, Nikolaos, Suddason, Tesha, Wu, Xuefeng, Anwar, Saba, Karin, Michael, Gallagher, Ewen

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central role for monocytes in Toll-like receptor-mediated activation of the vasculature by Ward, Jon R, Francis, Sheila E, Marsden, Luke, Suddason, Tesha, Lord, Graham M, Dower, Steven K, Crossman, David C, Sabroe, Ian

“…There is increasing evidence that activation of inflammatory responses in a variety of tissues is mediated co-operatively by the actions of more than one cell…”
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S.25. Identification and Manipulation of Novel Regulators of Th17 Development in Humans by Suddason, Tesha, Lord, Graham, Jackson, Ian, Lomabardi, Giovanna, Evans, Hayley, Taams, Leonie, Brett, Sara

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