Search Results - "Suddala, Krishna C."

Mg2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection by Suddala, Krishna C, Wang, Jiarui, Hou, Qian, Walter, Nils G

“…Bacterial riboswitches couple small-molecule ligand binding to RNA conformational changes that widely regulate gene expression, rendering them potential…”
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Direct observation of tRNA-chaperoned folding of a dynamic mRNA ensemble by Suddala, Krishna C., Yoo, Janghyun, Fan, Lixin, Zuo, Xiaobing, Wang, Yun-Xing, Chung, Hoi Sung, Zhang, Jinwei

“…T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid availabilities in most Gram-positive bacteria. T-boxes directly bind…”
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Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes by Suddala, Krishna C, Lee, Christine C, Meraner, Paul, Marin, Mariana, Markosyan, Ruben M, Desai, Tanay M, Cohen, Fredric S, Brass, Abraham L, Melikyan, Gregory B

“…Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly…”
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Hierarchical mechanism of amino acid sensing by the T-box riboswitch by Suddala, Krishna C., Cabello-Villegas, Javier, Michnicka, Malgorzata, Marshall, Collin, Nikonowicz, Edward P., Walter, Nils G.

“…In Gram-positive bacteria, T-box riboswitches control gene expression to maintain the cellular pools of aminoacylated tRNAs essential for protein biosynthesis…”
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Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch by Suddala, Krishna C., Price, Ian R., Dandpat, Shiba S., Janeček, Michal, Kührová, Petra, Šponer, Jiří, Banáš, Pavel, Ke, Ailong, Walter, Nils G.

“…The widespread Mn 2+ -sensing yybP-ykoY riboswitch controls the expression of bacterial Mn 2+ homeostasis genes. Here, we first determine the crystal structure…”
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Cycling of Etk and Etp phosphorylation states is involved in formation of group 4 capsule by Escherichia coli by Nadler, Chen, Koby, Simi, Peleg, Adi, Johnson, Austin C, Suddala, Krishna C, Sathiyamoorthy, Karthik, Smith, Bennett E, Saper, Mark A, Rosenshine, Ilan

“…Capsules frequently play a key role in bacterial interactions with their environment. Escherichia coli capsules were categorized as groups 1 through 4, each…”
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Structural analysis of a class III preQ₁ riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics by Liberman, Joseph A., Suddala, Krishna C., Aytenfisu, Asaminew, Chan, Dalen, Belashov, Ivan A., Salim, Mohammad, Mathews, David H., Spitale, Robert C., Walter, Nils G., Wedekind, Joseph E.

“…PreQ₁-III riboswitches are newly identified RNA elements that control bacterial genes in response to preQ₁ (7-aminomethyl-7-deazaguanine), a precursor to the…”
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High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove by Suddala, Krishna C., Zhang, Jinwei

“…T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino acid availability through direct interactions with tRNAs. Between the 5′…”
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Mg(2+) shifts ligand-mediated folding of a riboswitch from induced-fit to conformational selection by Suddala, Krishna C, Wang, Jiarui, Hou, Qian, Walter, Nils G

“…Bacterial riboswitches couple small-molecule ligand binding to RNA conformational changes that widely regulate gene expression, rendering them potential…”
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An evolving tale of two interacting RNAs—themes and variations of the T‐box riboswitch mechanism by Suddala, Krishna C., Zhang, Jinwei

“…T‐box riboswitches are a widespread class of structured noncoding RNAs in Gram‐positive bacteria that regulate the expression of amino acid‐related genes. They…”
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Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs by Hou, Qian, Chatterjee, Surajit, Lund, Paul E, Suddala, Krishna C, Walter, Nils G

“…Abstract Bacteria live in a broad range of environmental temperatures that require adaptations of their RNA sequences to maintain function. Riboswitches are…”
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Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure by Suddala, Krishna C, Rinaldi, Arlie J, Feng, Jun, Mustoe, Anthony M, Eichhorn, Catherine D, Liberman, Joseph A, Wedekind, Joseph E, Al-Hashimi, Hashim M, Brooks, 3rd, Charles L, Walter, Nils G

“…Riboswitches are structural elements in the 5' untranslated regions of many bacterial messenger RNAs that regulate gene expression in response to changing…”
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Riboswitch structure and dynamics by smFRET microscopy by Suddala, Krishna C, Walter, Nils G

“…Riboswitches are structured noncoding RNA elements that control the expression of their embedding messenger RNAs by sensing the intracellular concentration of…”
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Native purification and labeling of RNA for single molecule fluorescence studies by Rinaldi, Arlie J, Suddala, Krishna C, Walter, Nils G

“…The recent discovery that non-coding RNAs are considerably more abundant and serve a much wider range of critical cellular functions than recognized over…”
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Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch by Eichhorn, Catherine D., Feng, Jun, Suddala, Krishna C., Walter, Nils G., Brooks, Charles L., Al-Hashimi, Hashim M.

“…Single-stranded RNAs (ssRNAs) are ubiquitous RNA elements that serve diverse functional roles. Much of our understanding of ssRNA conformational behavior is…”
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An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gα q activation by Northup, John K, Tesmer, John J G, Lyon, Angeline M, Tesmer, Valerie M, Dhamsania, Vishan D, Thal, David M, Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C

“…By examining the structure of phospholipase C-β, an autoinhibitory helix that interacts with the catalytic core of this enzyme is now identified. Disrupting…”
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Meeting report: SMART timing-principles of single molecule techniques course at the University of Michigan 2014 by Bartke, Rebecca M., Cameron, Elizabeth L., Cristie-David, Ajitha S., Custer, Thomas C., Denies, Maxwell S., Daher, May, Dhakal, Soma, Ghosh, Soumi, Heinicke, Laurie A., Hoff, J. Damon, Hou, Qian, Kahlscheuer, Matthew L., Karslake, Joshua, Krieger, Adam G., Li, Jieming, Li, Xiang, Lund, Paul E., Vo, Nguyen N., Park, Jun, Pitchiaya, Sethuramasundaram, Rai, Victoria, Smith, David J., Suddala, Krishna C., Wang, Jiarui, Widom, Julia R., Walter, Nils G.

“…ABSTRACT Four days after the announcement of the 2014 Nobel Prize in Chemistry for “the development of super‐resolved fluorescence microscopy” based on single…”
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Mg 2+ Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection by Suddala, Krishna C., Wang, Jiarui, Hou, Qian, Walter, Nils G.

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Structural analysis of a class III preQ^sub 1^ riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics by Liberman, Joseph A, Suddala, Krishna C, Aytenfisu, Asaminew, Chan, Dalen, Belashov, Ivan A, Salim, Mohammad, Mathews, David H, Spitale, Robert C, Walter, Nils G, Wedekind, Joseph E

“…PreQ...-III riboswitches are newly identified RNA elements that control bacterial genes in response to preQ... (7-aminomethyl-7-deazaguanine), a precursor to…”
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Structural analysis of a class III preQ 1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics by Liberman, Joseph A., Suddala, Krishna C., Aytenfisu, Asaminew, Chan, Dalen, Belashov, Ivan A., Salim, Mohammad, Mathews, David H., Spitale, Robert C., Walter, Nils G., Wedekind, Joseph E.

“…Significance Riboswitches are RNA molecules found mostly in bacteria that control genes by sensing cellular levels of metabolites, such as the simple organic…”
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