Search Results - "Sudakin, V."

Human BUBR1 Is a Mitotic Checkpoint Kinase That Monitors CENP-E Functions at Kinetochores and Binds the Cyclosome/APC by Chan, G. K. T., Jablonski, S. A., Sudakin, V., Hittle, J. C., Yen, T. J.

“…Human cells express two kinases that are related to the yeast mitotic checkpoint kinase BUB1. hBUB1 and hBUBR1 bind to kinetochores where they are postulated…”
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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis by Sudakin, V, Ganoth, D, Dahan, A, Heller, H, Hershko, J, Luca, F C, Ruderman, J V, Hershko, A

“…The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four…”
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Reversible Phosphorylation Controls the Activity of Cyclosome-Associated Cyclin-Ubiquitin Ligase by Lahav-Baratz, Shirly, Sudakin, Valery, Ruderman, Joan V., Hershko, Avram

“…Cyclin B/cdc2 is responsible both for driving cells into mitosis and for activating the ubiquitin-dependent degradation of mitotic cyclins near the end of…”
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Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2 by HERSHKO, A, GANOTH, D, SUDAKIN, V, DAHAN, A, COHEN, L. H, LUCA, F. C, RUDERMAN, J. V, EYTAN, E

“…Cyclin B, a positive regulatory subunit of the cdc2 protein kinase complex, is synthesized across the cell cycle and then rapidly degraded at the end of…”
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Checkpoint Inhibition of the APC/C in HeLa Cells Is Mediated by a Complex of BUBR1, BUB3, CDC20, and MAD2 by Sudakin, Valery, Gordon K. T. Chan, Yen, Tim J.

“…The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome…”
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Binding of activated cyclosome to p13(suc1). Use for affinity purification by Sudakin, V, Shteinberg, M, Ganoth, D, Hershko, J, Hershko, A

“…Previous studies have indicated that a approximately 1,500-kDa complex, designated the cyclosome or anaphase-promoting complex, has a regulated…”
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Human BUBR1 is a miotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC by Chan, G K T, Jablonski, S A, Sudakin, V, Hittle, J C, Yen, T J

“…Human cells express two kinases that are related to the yeast mitotic checkpoint kinase BUB1. hBUB1 and hBUBR1 bind to kinetochores where they are postulated…”
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Preparation of clam oocyte extracts for cell cycle studies by Ruderman, J V, Sudakin, V, Hershko, A

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